| Rank | Drug | Target | Score | Validated | KEGG | DrugBank | Matador |
|---|
| 1 | D00182 ( Norethindrone ) | hsa2099 ( estrogen receptor 1 ) | 0.817781 | 0 | 0 | 0 | 0 |
| 2 | D00951 ( Medroxyprogesterone acetate ) | hsa2099 ( estrogen receptor 1 ) | 0.813644 | 1 | 0 | 1 | 0 |
| 3 | D01115 ( Eplerenone ) | hsa367 ( androgen receptor ) | 0.809348 | 0 | 0 | 0 | 0 |
| 4 | D00088 ( Hydrocortisone ) | hsa367 ( androgen receptor ) | 0.808296 | 0 | 0 | 0 | 0 |
| 5 | D00348 ( Isotretinoin ) | hsa6258 ( retinoid X receptor gamma ) | 0.807712 | 0 | 0 | 0 | 0 |
| 6 | D00690 ( Mometasone furoate ) | hsa367 ( androgen receptor ) | 0.801709 | 0 | 0 | 0 | 0 |
| 7 | D00348 ( Isotretinoin ) | hsa5915 ( retinoic acid receptor beta ) | 0.798388 | 1 | 1 | 0 | 0 |
| 8 | D01217 ( Dydrogesterone ) | hsa2099 ( estrogen receptor 1 ) | 0.794351 | 0 | 0 | 0 | 0 |
| 9 | D01115 ( Eplerenone ) | hsa5241 ( progesterone receptor ) | 0.79332 | 0 | 0 | 0 | 0 |
| 10 | D00279 ( Clofibrate ) | hsa5468 ( peroxisome proliferator activated receptor gamma ) | 0.793215 | 0 | 0 | 0 | 0 |
| 11 | D01387 ( Amcinonide ) | hsa367 ( androgen receptor ) | 0.792361 | 0 | 0 | 0 | 0 |
| 12 | D00506 ( Phenobarbital ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.791259 | 1 | 0 | 0 | 1 |
| 13 | D00690 ( Mometasone furoate ) | hsa2908 ( nuclear receptor subfamily 3 group C member 1 ) | 0.785763 | 1 | 1 | 1 | 0 |
| 14 | D00443 ( Spironolactone ) | hsa367 ( androgen receptor ) | 0.785396 | 1 | 0 | 1 | 0 |
| 15 | D00088 ( Hydrocortisone ) | hsa5241 ( progesterone receptor ) | 0.784484 | 0 | 0 | 0 | 0 |
| 16 | D00246 ( Budesonide ) | hsa367 ( androgen receptor ) | 0.783257 | 0 | 0 | 0 | 0 |
| 17 | D00163 ( Chenodiol ) | hsa7421 ( vitamin D receptor ) | 0.783013 | 0 | 0 | 0 | 0 |
| 18 | D00312 ( Estrone sodium sulfate ) | hsa2100 ( estrogen receptor 2 ) | 0.780573 | 1 | 1 | 0 | 0 |
| 19 | D01689 ( Loteprednol etabonate ) | hsa367 ( androgen receptor ) | 0.78044 | 0 | 0 | 0 | 0 |
| 20 | D00246 ( Budesonide ) | hsa5241 ( progesterone receptor ) | 0.7793 | 0 | 0 | 0 | 0 |
| 21 | D00443 ( Spironolactone ) | hsa5241 ( progesterone receptor ) | 0.778247 | 1 | 0 | 1 | 0 |
| 22 | D00554 ( Ethinyl estradiol ) | hsa2100 ( estrogen receptor 2 ) | 0.774617 | 1 | 1 | 0 | 0 |
| 23 | D00506 ( Phenobarbital ) | hsa7421 ( vitamin D receptor ) | 0.774604 | 0 | 0 | 0 | 0 |
| 24 | D01387 ( Amcinonide ) | hsa5241 ( progesterone receptor ) | 0.773517 | 0 | 0 | 0 | 0 |
| 25 | D00565 ( Fenofibrate ) | hsa5468 ( peroxisome proliferator activated receptor gamma ) | 0.771241 | 0 | 0 | 0 | 0 |
| 26 | D00075 ( Testosterone ) | hsa5241 ( progesterone receptor ) | 0.770684 | 0 | 0 | 0 | 0 |
| 27 | D00962 ( Clomiphene citrate ) | hsa2100 ( estrogen receptor 2 ) | 0.769531 | 1 | 1 | 0 | 0 |
| 28 | D00898 ( Dienestrol ) | hsa2100 ( estrogen receptor 2 ) | 0.768941 | 1 | 1 | 0 | 0 |
| 29 | D00182 ( Norethindrone ) | hsa367 ( androgen receptor ) | 0.768502 | 0 | 0 | 0 | 0 |
| 30 | D00067 ( Estrone ) | hsa2100 ( estrogen receptor 2 ) | 0.768082 | 1 | 1 | 0 | 0 |
| 31 | D00951 ( Medroxyprogesterone acetate ) | hsa367 ( androgen receptor ) | 0.767528 | 0 | 0 | 0 | 0 |
| 32 | D01217 ( Dydrogesterone ) | hsa367 ( androgen receptor ) | 0.767447 | 0 | 0 | 0 | 0 |
| 33 | D01689 ( Loteprednol etabonate ) | hsa5241 ( progesterone receptor ) | 0.764414 | 0 | 0 | 0 | 0 |
| 34 | D01115 ( Eplerenone ) | hsa2908 ( nuclear receptor subfamily 3 group C member 1 ) | 0.759056 | 0 | 0 | 0 | 0 |
| 35 | D00348 ( Isotretinoin ) | hsa5916 ( retinoic acid receptor gamma ) | 0.757843 | 1 | 1 | 0 | 0 |
| 36 | D00930 ( Paricalcitol ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.757811 | 0 | 0 | 0 | 0 |
| 37 | D00627 ( Telmisartan ) | hsa5465 ( peroxisome proliferator activated receptor alpha ) | 0.756587 | 0 | 0 | 0 | 0 |
| 38 | D00188 ( Cholecalciferol ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.754756 | 0 | 0 | 0 | 0 |
| 39 | D00690 ( Mometasone furoate ) | hsa2099 ( estrogen receptor 1 ) | 0.748015 | 0 | 0 | 0 | 0 |
| 40 | D00730 ( Butamben ) | hsa7421 ( vitamin D receptor ) | 0.747451 | 0 | 0 | 0 | 0 |
| 41 | D00327 ( Fluoxymesterone ) | hsa5241 ( progesterone receptor ) | 0.746177 | 0 | 0 | 0 | 0 |
| 42 | D00187 ( Ergocalciferol ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.743099 | 0 | 0 | 0 | 0 |
| 43 | D00950 ( Levonorgestrel ) | hsa367 ( androgen receptor ) | 0.742766 | 1 | 0 | 1 | 0 |
| 44 | D00299 ( Dihydrotachysterol ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.7424 | 0 | 0 | 0 | 0 |
| 45 | D05341 ( Palmitic acid ) | hsa2099 ( estrogen receptor 1 ) | 0.740663 | 0 | 0 | 0 | 0 |
| 46 | D00596 ( Rosiglitazone maleate ) | hsa5465 ( peroxisome proliferator activated receptor alpha ) | 0.740267 | 0 | 0 | 0 | 0 |
| 47 | D00129 ( Calcitriol ) | hsa8856 ( nuclear receptor subfamily 1 group I member 2 ) | 0.738637 | 0 | 0 | 0 | 0 |
| 48 | D00954 ( Norgestrel ) | hsa367 ( androgen receptor ) | 0.731979 | 0 | 0 | 0 | 0 |
| 49 | D00316 ( Etretinate ) | hsa6096 ( RAR related orphan receptor B ) | 0.728371 | 0 | 0 | 0 | 0 |
| 50 | D00956 ( Nandrolone phenpropionate ) | hsa5241 ( progesterone receptor ) | 0.728253 | 0 | 0 | 0 | 0 |