Predicted Drug-Target interactions

In total 341 out of top-10 predicted DTIs per drug were validated.
In total, 618 validated new DTIs are known for gpcr dataset, however please note that at most 465 DTIs could be predicted (i.e., some drugs have more than 10 validated DTIs).

D00049 : Niacin (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00049 ( Niacin )

Rank	Target	Score	Validated	DrugBank
1	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.907703	1	1
2	hsa185 ( angiotensin II receptor type 1 )	0.727639	0	0
3	hsa154 ( adrenoceptor beta 2 )	0.712188	0	0
4	hsa153 ( adrenoceptor beta 1 )	0.689806	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.66573	0	0
6	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.624499	0	0
7	hsa1813 ( dopamine receptor D2 )	0.613097	0	0
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.605993	0	0
9	hsa4988 ( opioid receptor mu 1 )	0.603404	0	0
10	hsa6010 ( rhodopsin )	0.597581	0	0

D00059 : Levodopa (Found 2 out of 3 validated targets)

Top-10 predicted interaction for: D00059 ( Levodopa )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.931127	1	1	1
2	hsa1816 ( dopamine receptor D5 )	0.881399	1	1	1
3	hsa154 ( adrenoceptor beta 2 )	0.804541	0	0	0
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.795459	0	0	0
5	hsa3269 ( histamine receptor H1 )	0.775413	0	0	0
6	hsa153 ( adrenoceptor beta 1 )	0.770575	0	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.76211	0	0	0
8	hsa151 ( adrenoceptor alpha 2B )	0.751384	0	0	0
9	hsa148 ( adrenoceptor alpha 1A )	0.74428	0	0	0
10	hsa4985 ( opioid receptor delta 1 )	0.651287	0	0	0

D00079 : Dinoprostone (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D00079 ( Dinoprostone )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa5731 ( prostaglandin E receptor 1 )	0.941942	1	0	1
2	hsa5737 ( prostaglandin F receptor )	0.906	0	0	0
3	hsa5732 ( prostaglandin E receptor 2 )	0.870486	1	1	1
4	hsa5733 ( prostaglandin E receptor 3 )	0.791449	1	0	1
5	hsa64805 ( purinergic receptor P2Y12 )	0.723763	0	0	0
6	hsa6915 ( thromboxane A2 receptor )	0.714098	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.711709	0	0	0
8	hsa153 ( adrenoceptor beta 1 )	0.701301	0	0	0
9	hsa3269 ( histamine receptor H1 )	0.650125	0	0	0
10	hsa4988 ( opioid receptor mu 1 )	0.631017	0	0	0

D00094 : Tretinoin (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00094 ( Tretinoin )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.773193
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.720709
3	hsa150 ( adrenoceptor alpha 2A )	0.683609
4	hsa1129 ( cholinergic receptor muscarinic 2 )	0.675475
5	hsa3269 ( histamine receptor H1 )	0.662581
6	hsa152 ( adrenoceptor alpha 2C )	0.631487
7	hsa151 ( adrenoceptor alpha 2B )	0.629329
8	hsa154 ( adrenoceptor beta 2 )	0.617708
9	hsa4988 ( opioid receptor mu 1 )	0.601763
10	hsa23620 ( neurotensin receptor 2 )	0.578044

D00095 : Epinephrine (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D00095 ( Epinephrine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa155 ( adrenoceptor beta 3 )	0.940071	1	1	1
2	hsa146 ( adrenoceptor alpha 1D )	0.842186	1	1	1
3	hsa147 ( adrenoceptor alpha 1B )	0.831339	1	1	1
4	hsa3274 ( histamine receptor H2 )	0.762238	0	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.676406	1	1	1
6	hsa151 ( adrenoceptor alpha 2B )	0.671383	1	1	1
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.555688	0	0	0
8	hsa1812 ( dopamine receptor D1 )	0.537359	0	0	0
9	hsa152 ( adrenoceptor alpha 2C )	0.537266	1	1	1
10	hsa3269 ( histamine receptor H1 )	0.531445	0	0	0

D00106 : Epoprostenol (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00106 ( Epoprostenol )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.805892	1	1	1
2	hsa5731 ( prostaglandin E receptor 1 )	0.738412	0	0	0
3	hsa5737 ( prostaglandin F receptor )	0.723369	0	0	0
4	hsa4988 ( opioid receptor mu 1 )	0.708229	0	0	0
5	hsa185 ( angiotensin II receptor type 1 )	0.707933	0	0	0
6	hsa134 ( adenosine A1 receptor )	0.679691	0	0	0
7	hsa136 ( adenosine A2b receptor )	0.667929	0	0	0
8	hsa135 ( adenosine A2a receptor )	0.652286	0	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.64307	0	0	0
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.635878	0	0	0

D00110 : Cocaine (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D00110 ( Cocaine )

Rank	Target	Score	Validated	DrugBank
1	hsa4988 ( opioid receptor mu 1 )	0.931873	0	0
2	hsa1813 ( dopamine receptor D2 )	0.928317	0	0
3	hsa4985 ( opioid receptor delta 1 )	0.895145	0	0
4	hsa1816 ( dopamine receptor D5 )	0.862505	0	0
5	hsa3269 ( histamine receptor H1 )	0.766664	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.697207	0	0
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.687305	1	1
8	hsa154 ( adrenoceptor beta 2 )	0.67916	0	0
9	hsa185 ( angiotensin II receptor type 1 )	0.673399	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.66728	0	0

D00113 : Atropine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00113 ( Atropine )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.936278
2	hsa1813 ( dopamine receptor D2 )	0.648265
3	hsa4988 ( opioid receptor mu 1 )	0.629282
4	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.570224
5	hsa154 ( adrenoceptor beta 2 )	0.567054
6	hsa1815 ( dopamine receptor D4 )	0.562958
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.560831
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.549081
9	hsa11255 ( histamine receptor H3 )	0.541475
10	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.51099

D00136 : Haloperidol (Found 6 out of 17 validated targets)

Top-10 predicted interaction for: D00136 ( Haloperidol )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa152 ( adrenoceptor alpha 2C )	0.919899	0	0	0
2	hsa1812 ( dopamine receptor D1 )	0.904972	1	1	0
3	hsa148 ( adrenoceptor alpha 1A )	0.901064	1	0	1
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.885969	1	1	0
5	hsa146 ( adrenoceptor alpha 1D )	0.870714	1	0	1
6	hsa147 ( adrenoceptor alpha 1B )	0.856573	1	0	1
7	hsa1816 ( dopamine receptor D5 )	0.799201	0	0	0
8	hsa3269 ( histamine receptor H1 )	0.725857	0	0	0
9	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.697801	1	0	1
10	hsa1815 ( dopamine receptor D4 )	0.622077	0	0	0

D00139 : Methoxsalen (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00139 ( Methoxsalen )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.793167
2	hsa154 ( adrenoceptor beta 2 )	0.667299
3	hsa150 ( adrenoceptor alpha 2A )	0.663563
4	hsa153 ( adrenoceptor beta 1 )	0.652562
5	hsa4988 ( opioid receptor mu 1 )	0.620268
6	hsa136 ( adenosine A2b receptor )	0.618639
7	hsa134 ( adenosine A1 receptor )	0.596724
8	hsa1813 ( dopamine receptor D2 )	0.595125
9	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.582632
10	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.582523

D00180 : Alprostadil (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00180 ( Alprostadil )

Rank	Target	Score
1	hsa5733 ( prostaglandin E receptor 3 )	0.942957
2	hsa5737 ( prostaglandin F receptor )	0.939642
3	hsa6915 ( thromboxane A2 receptor )	0.820854
4	hsa4988 ( opioid receptor mu 1 )	0.680603
5	hsa5729 ( prostaglandin D2 receptor )	0.677384
6	hsa64805 ( purinergic receptor P2Y12 )	0.654855
7	hsa153 ( adrenoceptor beta 1 )	0.638273
8	hsa154 ( adrenoceptor beta 2 )	0.637655
9	hsa3274 ( histamine receptor H2 )	0.615052
10	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.594109

D00225 : Alprazolam (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00225 ( Alprazolam )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.797381
2	hsa150 ( adrenoceptor alpha 2A )	0.680489
3	hsa1813 ( dopamine receptor D2 )	0.663329
4	hsa148 ( adrenoceptor alpha 1A )	0.659882
5	hsa154 ( adrenoceptor beta 2 )	0.603602
6	hsa153 ( adrenoceptor beta 1 )	0.595537
7	hsa4988 ( opioid receptor mu 1 )	0.592707
8	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.591479
9	hsa151 ( adrenoceptor alpha 2B )	0.590233
10	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.58915

D00227 : Aminophylline (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00227 ( Aminophylline )

Rank	Target	Score
1	hsa136 ( adenosine A2b receptor )	0.945137
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.854606
3	hsa64805 ( purinergic receptor P2Y12 )	0.774109
4	hsa185 ( angiotensin II receptor type 1 )	0.768488
5	hsa150 ( adrenoceptor alpha 2A )	0.672349
6	hsa154 ( adrenoceptor beta 2 )	0.642423
7	hsa5731 ( prostaglandin E receptor 1 )	0.615789
8	hsa6915 ( thromboxane A2 receptor )	0.61186
9	hsa153 ( adrenoceptor beta 1 )	0.609565
10	hsa5029 ( purinergic receptor P2Y2 )	0.598478

D00232 : Anisotropine methylbromide (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00232 ( Anisotropine methylbromide )

Rank	Target	Score	Validated	KEGG
1	hsa1132 ( cholinergic receptor muscarinic 4 )	0.914212	1	1
2	hsa3269 ( histamine receptor H1 )	0.904487	0	0
3	hsa1133 ( cholinergic receptor muscarinic 5 )	0.87923	1	1
4	hsa4988 ( opioid receptor mu 1 )	0.659388	0	0
5	hsa1813 ( dopamine receptor D2 )	0.627981	0	0
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.557906	0	0
7	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.550128	0	0
8	hsa185 ( angiotensin II receptor type 1 )	0.548019	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.547162	0	0
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.542243	0	0

D00234 : Astemizole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00234 ( Astemizole )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.788897
2	hsa1813 ( dopamine receptor D2 )	0.739942
3	hsa148 ( adrenoceptor alpha 1A )	0.691814
4	hsa1812 ( dopamine receptor D1 )	0.67541
5	hsa1129 ( cholinergic receptor muscarinic 2 )	0.663024
6	hsa3274 ( histamine receptor H2 )	0.657514
7	hsa1131 ( cholinergic receptor muscarinic 3 )	0.625764
8	hsa4988 ( opioid receptor mu 1 )	0.624952
9	hsa23620 ( neurotensin receptor 2 )	0.591225
10	hsa154 ( adrenoceptor beta 2 )	0.574847

D00235 : Atenolol (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00235 ( Atenolol )

Rank	Target	Score	Validated	Matador
1	hsa155 ( adrenoceptor beta 3 )	0.935568	1	1
2	hsa3274 ( histamine receptor H2 )	0.689467	0	0
3	hsa148 ( adrenoceptor alpha 1A )	0.684525	0	0
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.613616	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.572341	0	0
6	hsa146 ( adrenoceptor alpha 1D )	0.54959	0	0
7	hsa1812 ( dopamine receptor D1 )	0.548066	0	0
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.532653	0	0
9	hsa150 ( adrenoceptor alpha 2A )	0.532387	0	0
10	hsa147 ( adrenoceptor alpha 1B )	0.516897	0	0

D00241 : Baclofen (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00241 ( Baclofen )

Rank	Target	Score
1	hsa1813 ( dopamine receptor D2 )	0.747099
2	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.72349
3	hsa6915 ( thromboxane A2 receptor )	0.703266
4	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.701355
5	hsa185 ( angiotensin II receptor type 1 )	0.690968
6	hsa1812 ( dopamine receptor D1 )	0.644934
7	hsa64805 ( purinergic receptor P2Y12 )	0.641656
8	hsa1814 ( dopamine receptor D3 )	0.632852
9	hsa4988 ( opioid receptor mu 1 )	0.611777
10	hsa154 ( adrenoceptor beta 2 )	0.6044

D00255 : Carvedilol (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00255 ( Carvedilol )

Rank	Target	Score	Validated	DrugBank
1	hsa152 ( adrenoceptor alpha 2C )	0.867871	1	1
2	hsa3274 ( histamine receptor H2 )	0.661977	0	0
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.617847	0	0
4	hsa1813 ( dopamine receptor D2 )	0.565293	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.560061	0	0
6	hsa3269 ( histamine receptor H1 )	0.55541	0	0
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.547141	0	0
8	hsa1129 ( cholinergic receptor muscarinic 2 )	0.497421	0	0
9	hsa1812 ( dopamine receptor D1 )	0.492331	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.464554	0	0

D00270 : Chlorpromazine (Found 9 out of 17 validated targets)

Top-10 predicted interaction for: D00270 ( Chlorpromazine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3269 ( histamine receptor H1 )	0.871011	1	1	1
2	hsa152 ( adrenoceptor alpha 2C )	0.801394	1	1	1
3	hsa148 ( adrenoceptor alpha 1A )	0.77761	1	0	1
4	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.729134	1	1	1
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.706383	1	1	1
6	hsa146 ( adrenoceptor alpha 1D )	0.68708	1	0	1
7	hsa1815 ( dopamine receptor D4 )	0.672977	1	0	1
8	hsa147 ( adrenoceptor alpha 1B )	0.65579	1	0	1
9	hsa154 ( adrenoceptor beta 2 )	0.631687	0	0	0
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.591602	1	1	0

D00274 : Cisapride (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00274 ( Cisapride )

Rank	Target	Score	Validated	DrugBank
1	hsa3269 ( histamine receptor H1 )	0.862649	0	0
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.85199	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.739906	0	0
4	hsa154 ( adrenoceptor beta 2 )	0.694484	0	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.676807	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.668101	1	1
7	hsa1812 ( dopamine receptor D1 )	0.658224	0	0
8	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.635281	0	0
9	hsa1813 ( dopamine receptor D2 )	0.63423	0	0
10	hsa148 ( adrenoceptor alpha 1A )	0.617243	0	0

D00281 : Clonidine (Found 1 out of 11 validated targets)

Top-10 predicted interaction for: D00281 ( Clonidine )

Rank	Target	Score	Validated	Matador
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.659689	1	1
2	hsa153 ( adrenoceptor beta 1 )	0.65347	0	0
3	hsa1813 ( dopamine receptor D2 )	0.638566	0	0
4	hsa154 ( adrenoceptor beta 2 )	0.605509	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.586057	0	0
6	hsa185 ( angiotensin II receptor type 1 )	0.581703	0	0
7	hsa155 ( adrenoceptor beta 3 )	0.562777	0	0
8	hsa3274 ( histamine receptor H2 )	0.538735	0	0
9	hsa3269 ( histamine receptor H1 )	0.529668	0	0
10	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.516905	0	0

D00283 : Clozapine (Found 5 out of 5 validated targets)

Top-10 predicted interaction for: D00283 ( Clozapine )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa1814 ( dopamine receptor D3 )	0.932327	1	1	1
2	hsa152 ( adrenoceptor alpha 2C )	0.751564	1	1	0
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.668531	1	1	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.590385	1	1	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.550672	1	1	0
6	hsa3274 ( histamine receptor H2 )	0.493377	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.464469	0	0	0
8	hsa11255 ( histamine receptor H3 )	0.459317	0	0	0
9	hsa153 ( adrenoceptor beta 1 )	0.444063	0	0	0
10	hsa155 ( adrenoceptor beta 3 )	0.352834	0	0	0

D00295 : Cimetidine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00295 ( Cimetidine )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.839386
2	hsa153 ( adrenoceptor beta 1 )	0.813715
3	hsa148 ( adrenoceptor alpha 1A )	0.749967
4	hsa3269 ( histamine receptor H1 )	0.727448
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.697506
6	hsa59340 ( histamine receptor H4 )	0.688039
7	hsa155 ( adrenoceptor beta 3 )	0.673099
8	hsa136 ( adenosine A2b receptor )	0.628982
9	hsa147 ( adrenoceptor alpha 1B )	0.626942
10	hsa146 ( adrenoceptor alpha 1D )	0.615554

D00300 : Diphenhydramine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00300 ( Diphenhydramine )

Rank	Target	Score	Validated	DrugBank
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.873525	0	0
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.78571	1	1
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.744745	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.676747	0	0
5	hsa3274 ( histamine receptor H2 )	0.670961	0	0
6	hsa1813 ( dopamine receptor D2 )	0.645796	0	0
7	hsa4988 ( opioid receptor mu 1 )	0.61454	0	0
8	hsa23620 ( neurotensin receptor 2 )	0.611514	0	0
9	hsa1132 ( cholinergic receptor muscarinic 4 )	0.593655	0	0
10	hsa1133 ( cholinergic receptor muscarinic 5 )	0.572325	0	0

D00301 : Atropine sulfate - diphenoxylate hydrochloride mixt (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00301 ( Atropine sulfate - diphenoxylate hydrochloride mixt )

Rank	Target	Score
1	hsa4986 ( opioid receptor kappa 1 )	0.909566
2	hsa4985 ( opioid receptor delta 1 )	0.814708
3	hsa185 ( angiotensin II receptor type 1 )	0.796067
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.717855
5	hsa6752 ( somatostatin receptor 2 )	0.715919
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.689469
7	hsa1129 ( cholinergic receptor muscarinic 2 )	0.669289
8	hsa6755 ( somatostatin receptor 5 )	0.668708
9	hsa7201 ( thyrotropin releasing hormone receptor )	0.65601
10	hsa3269 ( histamine receptor H1 )	0.655621

D00306 : Dronabinol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00306 ( Dronabinol )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.735976
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.735566
3	hsa136 ( adenosine A2b receptor )	0.732012
4	hsa153 ( adrenoceptor beta 1 )	0.697511
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.660756
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.649275
7	hsa3274 ( histamine receptor H2 )	0.640139
8	hsa4988 ( opioid receptor mu 1 )	0.633888
9	hsa150 ( adrenoceptor alpha 2A )	0.619597
10	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.619527

D00318 : Famotidine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00318 ( Famotidine )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.854999
2	hsa154 ( adrenoceptor beta 2 )	0.769471
3	hsa153 ( adrenoceptor beta 1 )	0.766538
4	hsa148 ( adrenoceptor alpha 1A )	0.737515
5	hsa5731 ( prostaglandin E receptor 1 )	0.595654
6	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.593899
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.592228
8	hsa155 ( adrenoceptor beta 3 )	0.581665
9	hsa5733 ( prostaglandin E receptor 3 )	0.565049
10	hsa6915 ( thromboxane A2 receptor )	0.550227

D00332 : Gabapentin (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00332 ( Gabapentin )

Rank	Target	Score
1	hsa152 ( adrenoceptor alpha 2C )	0.927724
2	hsa151 ( adrenoceptor alpha 2B )	0.917592
3	hsa135 ( adenosine A2a receptor )	0.902236
4	hsa136 ( adenosine A2b receptor )	0.852107
5	hsa140 ( adenosine A3 receptor )	0.81013
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.775608
7	hsa146 ( adrenoceptor alpha 1D )	0.656732
8	hsa185 ( angiotensin II receptor type 1 )	0.65096
9	hsa148 ( adrenoceptor alpha 1A )	0.640099
10	hsa1813 ( dopamine receptor D2 )	0.639775

D00336 : Glyburide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00336 ( Glyburide )

Rank	Target	Score
1	hsa5737 ( prostaglandin F receptor )	0.822628
2	hsa5731 ( prostaglandin E receptor 1 )	0.771936
3	hsa1813 ( dopamine receptor D2 )	0.749009
4	hsa5733 ( prostaglandin E receptor 3 )	0.742788
5	hsa4988 ( opioid receptor mu 1 )	0.712363
6	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.678149
7	hsa1814 ( dopamine receptor D3 )	0.659752
8	hsa5732 ( prostaglandin E receptor 2 )	0.646564
9	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.626999
10	hsa154 ( adrenoceptor beta 2 )	0.624816

D00356 : Latanoprost (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00356 ( Latanoprost )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.915102
2	hsa5733 ( prostaglandin E receptor 3 )	0.903361
3	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.884795
4	hsa6915 ( thromboxane A2 receptor )	0.86445
5	hsa5732 ( prostaglandin E receptor 2 )	0.834725
6	hsa4988 ( opioid receptor mu 1 )	0.67528
7	hsa154 ( adrenoceptor beta 2 )	0.665418
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.658127
9	hsa153 ( adrenoceptor beta 1 )	0.634593
10	hsa64805 ( purinergic receptor P2Y12 )	0.62583

D00364 : Loratadine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00364 ( Loratadine )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.89645
2	hsa1813 ( dopamine receptor D2 )	0.850079
3	hsa1129 ( cholinergic receptor muscarinic 2 )	0.843066
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.796716
5	hsa1131 ( cholinergic receptor muscarinic 3 )	0.782337
6	hsa1812 ( dopamine receptor D1 )	0.779369
7	hsa59340 ( histamine receptor H4 )	0.713572
8	hsa148 ( adrenoceptor alpha 1A )	0.678726
9	hsa1814 ( dopamine receptor D3 )	0.668586
10	hsa11255 ( histamine receptor H3 )	0.66395

D00371 : Theophylline (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00371 ( Theophylline )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa135 ( adenosine A2a receptor )	0.930168	1	1	1
2	hsa134 ( adenosine A1 receptor )	0.929486	1	1	1
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.859366	0	0	0
4	hsa140 ( adenosine A3 receptor )	0.858282	0	0	0
5	hsa185 ( angiotensin II receptor type 1 )	0.798431	0	0	0
6	hsa64805 ( purinergic receptor P2Y12 )	0.754838	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.66805	0	0	0
8	hsa1268 ( cannabinoid receptor 1 )	0.64365	0	0	0
9	hsa153 ( adrenoceptor beta 1 )	0.63772	0	0	0
10	hsa5029 ( purinergic receptor P2Y2 )	0.620054	0	0	0

D00380 : Tolbutamide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00380 ( Tolbutamide )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.777497
2	hsa154 ( adrenoceptor beta 2 )	0.669432
3	hsa153 ( adrenoceptor beta 1 )	0.642499
4	hsa4988 ( opioid receptor mu 1 )	0.639675
5	hsa136 ( adenosine A2b receptor )	0.63899
6	hsa150 ( adrenoceptor alpha 2A )	0.638667
7	hsa134 ( adenosine A1 receptor )	0.618168
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.597821
9	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.586693
10	hsa135 ( adenosine A2a receptor )	0.580699

D00394 : Trimipramine (Found 9 out of 20 validated targets)

Top-10 predicted interaction for: D00394 ( Trimipramine )

Rank	Target	Score	Validated	DrugBank
1	hsa185 ( angiotensin II receptor type 1 )	0.765925	0	0
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.722159	1	1
3	hsa3269 ( histamine receptor H1 )	0.677759	1	1
4	hsa1813 ( dopamine receptor D2 )	0.665267	1	1
5	hsa1129 ( cholinergic receptor muscarinic 2 )	0.657047	1	1
6	hsa150 ( adrenoceptor alpha 2A )	0.640759	1	1
7	hsa148 ( adrenoceptor alpha 1A )	0.616402	1	1
8	hsa154 ( adrenoceptor beta 2 )	0.603719	1	1
9	hsa1131 ( cholinergic receptor muscarinic 3 )	0.592944	1	1
10	hsa153 ( adrenoceptor beta 1 )	0.583489	1	1

D00397 : Tropicamide (Found 2 out of 3 validated targets)

Top-10 predicted interaction for: D00397 ( Tropicamide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.965068	1	1	1
2	hsa3269 ( histamine receptor H1 )	0.933411	0	0	0
3	hsa1133 ( cholinergic receptor muscarinic 5 )	0.896022	1	1	0
4	hsa154 ( adrenoceptor beta 2 )	0.641334	0	0	0
5	hsa1813 ( dopamine receptor D2 )	0.628492	0	0	0
6	hsa11255 ( histamine receptor H3 )	0.597541	0	0	0
7	hsa153 ( adrenoceptor beta 1 )	0.584192	0	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.548745	0	0	0
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.544245	0	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.540977	0	0	0

D00400 : Valsartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00400 ( Valsartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.853692
2	hsa4988 ( opioid receptor mu 1 )	0.783732
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.698926
4	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.661661
5	hsa148 ( adrenoceptor alpha 1A )	0.639264
6	hsa4986 ( opioid receptor kappa 1 )	0.604293
7	hsa136 ( adenosine A2b receptor )	0.583883
8	hsa64805 ( purinergic receptor P2Y12 )	0.578938
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.569285
10	hsa338442 ( hydroxycarboxylic acid receptor 2 )	0.56349

D00410 : Metyrapone (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00410 ( Metyrapone )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.795048
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.678249
3	hsa4988 ( opioid receptor mu 1 )	0.676708
4	hsa1129 ( cholinergic receptor muscarinic 2 )	0.6181
5	hsa154 ( adrenoceptor beta 2 )	0.612586
6	hsa3269 ( histamine receptor H1 )	0.594848
7	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.589593
8	hsa153 ( adrenoceptor beta 1 )	0.58723
9	hsa136 ( adenosine A2b receptor )	0.586617
10	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.583408

D00411 : Zafirlukast (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00411 ( Zafirlukast )

Rank	Target	Score
1	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.800032
2	hsa3269 ( histamine receptor H1 )	0.785203
3	hsa5729 ( prostaglandin D2 receptor )	0.765794
4	hsa185 ( angiotensin II receptor type 1 )	0.738662
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.700605
6	hsa1128 ( cholinergic receptor muscarinic 1 )	0.675188
7	hsa1813 ( dopamine receptor D2 )	0.64238
8	hsa9283 ( G protein-coupled receptor 37 like 1 )	0.625945
9	hsa4988 ( opioid receptor mu 1 )	0.618581
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.604998

D00415 : Zolmitriptan (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00415 ( Zolmitriptan )

Rank	Target	Score	Validated	DrugBank
1	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.962918	1	1
2	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.902729	1	1
3	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.872437	0	0
4	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.850707	0	0
5	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.848936	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.83967	0	0
7	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.827982	0	0
8	hsa148 ( adrenoceptor alpha 1A )	0.811233	0	0
9	hsa1814 ( dopamine receptor D3 )	0.786562	0	0
10	hsa150 ( adrenoceptor alpha 2A )	0.780169	0	0

D00419 : Misoprostol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00419 ( Misoprostol )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.958706
2	hsa5737 ( prostaglandin F receptor )	0.91429
3	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.901886
4	hsa6915 ( thromboxane A2 receptor )	0.816608
5	hsa154 ( adrenoceptor beta 2 )	0.685244
6	hsa153 ( adrenoceptor beta 1 )	0.681794
7	hsa4988 ( opioid receptor mu 1 )	0.681214
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.648175
9	hsa5729 ( prostaglandin D2 receptor )	0.64656
10	hsa185 ( angiotensin II receptor type 1 )	0.63932

D00422 : Ranitidine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00422 ( Ranitidine )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.842865
2	hsa153 ( adrenoceptor beta 1 )	0.818155
3	hsa148 ( adrenoceptor alpha 1A )	0.733537
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.700767
5	hsa3269 ( histamine receptor H1 )	0.700523
6	hsa155 ( adrenoceptor beta 3 )	0.681085
7	hsa59340 ( histamine receptor H4 )	0.679205
8	hsa136 ( adenosine A2b receptor )	0.66449
9	hsa147 ( adrenoceptor alpha 1B )	0.605366
10	hsa11255 ( histamine receptor H3 )	0.59723

D00426 : Risperidone (Found 9 out of 14 validated targets)

Top-10 predicted interaction for: D00426 ( Risperidone )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa151 ( adrenoceptor alpha 2B )	0.858261	1	0	1	1
2	hsa150 ( adrenoceptor alpha 2A )	0.844139	1	0	1	1
3	hsa1813 ( dopamine receptor D2 )	0.832488	1	1	1	1
4	hsa3269 ( histamine receptor H1 )	0.774612	1	0	1	1
5	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.762039	1	0	1	1
6	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.733702	1	0	1	0
7	hsa152 ( adrenoceptor alpha 2C )	0.702966	1	0	1	0
8	hsa1814 ( dopamine receptor D3 )	0.702277	1	0	1	1
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.694246	0	0	0	0
10	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.679785	1	0	0	1

D00432 : Nadolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00432 ( Nadolol )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.771735
2	hsa3274 ( histamine receptor H2 )	0.723263
3	hsa146 ( adrenoceptor alpha 1D )	0.663565
4	hsa150 ( adrenoceptor alpha 2A )	0.627863
5	hsa147 ( adrenoceptor alpha 1B )	0.626335
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.594971
7	hsa151 ( adrenoceptor alpha 2B )	0.593551
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.549625
9	hsa1812 ( dopamine receptor D1 )	0.525238
10	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.523978

D00437 : Nifedipine (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00437 ( Nifedipine )

Rank	Target	Score	Validated	Matador
1	hsa152 ( adrenoceptor alpha 2C )	0.868942	0	0
2	hsa3274 ( histamine receptor H2 )	0.664496	0	0
3	hsa185 ( angiotensin II receptor type 1 )	0.53032	0	0
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.525819	0	0
5	hsa1813 ( dopamine receptor D2 )	0.501805	0	0
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.46917	0	0
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.468036	1	1
8	hsa1812 ( dopamine receptor D1 )	0.458001	0	0
9	hsa3269 ( histamine receptor H1 )	0.439109	0	0
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.427525	1	1

D00440 : Nizatidine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00440 ( Nizatidine )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.817155
2	hsa153 ( adrenoceptor beta 1 )	0.790415
3	hsa148 ( adrenoceptor alpha 1A )	0.716639
4	hsa3269 ( histamine receptor H1 )	0.714341
5	hsa59340 ( histamine receptor H4 )	0.701929
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.69868
7	hsa136 ( adenosine A2b receptor )	0.656059
8	hsa155 ( adrenoceptor beta 3 )	0.646369
9	hsa11255 ( histamine receptor H3 )	0.623727
10	hsa147 ( adrenoceptor alpha 1B )	0.588266

D00442 : Octreotide (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00442 ( Octreotide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa6755 ( somatostatin receptor 5 )	0.948372	1	1	1
2	hsa4988 ( opioid receptor mu 1 )	0.945831	0	0	0
3	hsa6753 ( somatostatin receptor 3 )	0.928447	1	1	0
4	hsa4986 ( opioid receptor kappa 1 )	0.812426	0	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.737898	0	0	0
6	hsa185 ( angiotensin II receptor type 1 )	0.734752	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.725275	0	0	0
8	hsa4985 ( opioid receptor delta 1 )	0.716939	0	0	0
9	hsa153 ( adrenoceptor beta 1 )	0.689042	0	0	0
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.662373	0	0	0

D00443 : Spironolactone (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00443 ( Spironolactone )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.83024
2	hsa4988 ( opioid receptor mu 1 )	0.82642
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.70326
4	hsa4986 ( opioid receptor kappa 1 )	0.65459
5	hsa148 ( adrenoceptor alpha 1A )	0.642864
6	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.641935
7	hsa64805 ( purinergic receptor P2Y12 )	0.635513
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.608121
9	hsa136 ( adenosine A2b receptor )	0.601893
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.587486

D00451 : Sumatriptan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00451 ( Sumatriptan )

Rank	Target	Score
1	hsa1814 ( dopamine receptor D3 )	0.868519
2	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.85547
3	hsa148 ( adrenoceptor alpha 1A )	0.835458
4	hsa1813 ( dopamine receptor D2 )	0.792786
5	hsa150 ( adrenoceptor alpha 2A )	0.756993
6	hsa154 ( adrenoceptor beta 2 )	0.734112
7	hsa147 ( adrenoceptor alpha 1B )	0.733183
8	hsa146 ( adrenoceptor alpha 1D )	0.727662
9	hsa153 ( adrenoceptor beta 1 )	0.689023
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.668288

D00454 : Olanzapine (Found 7 out of 10 validated targets)

Top-10 predicted interaction for: D00454 ( Olanzapine )

Rank	Target	Score	Validated	DrugBank
1	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.632484	0	0
2	hsa152 ( adrenoceptor alpha 2C )	0.606689	1	1
3	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.527373	1	1
4	hsa3274 ( histamine receptor H2 )	0.483531	1	1
5	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.47904	1	1
6	hsa59340 ( histamine receptor H4 )	0.402247	1	1
7	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.334921	1	1
8	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.316094	0	0
9	hsa11255 ( histamine receptor H3 )	0.303664	0	0
10	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.285238	1	1

D00465 : Oxybutynin (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00465 ( Oxybutynin )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.951429	1	1	1
2	hsa3269 ( histamine receptor H1 )	0.920883	0	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.889927	0	0	0
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.850752	0	0	0
5	hsa1813 ( dopamine receptor D2 )	0.679341	0	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.609996	0	0	0
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.581137	0	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.578969	0	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.562257	0	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.560539	0	0	0

D00480 : Promethazine hydrochloride (Found 9 out of 10 validated targets)

Top-10 predicted interaction for: D00480 ( Promethazine hydrochloride )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.921002	1	1	1
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.879786	1	1	1
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.832379	1	1	0
4	hsa1813 ( dopamine receptor D2 )	0.788511	1	1	0
5	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.709334	1	1	0
6	hsa1132 ( cholinergic receptor muscarinic 4 )	0.701261	1	1	0
7	hsa59340 ( histamine receptor H4 )	0.698821	1	0	1
8	hsa1812 ( dopamine receptor D1 )	0.693665	0	0	0
9	hsa11255 ( histamine receptor H3 )	0.686621	1	0	1
10	hsa148 ( adrenoceptor alpha 1A )	0.679772	1	1	0

D00483 : Propranolol hydrochloride (Found 2 out of 11 validated targets)

Top-10 predicted interaction for: D00483 ( Propranolol hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa148 ( adrenoceptor alpha 1A )	0.793554	0	0
2	hsa3274 ( histamine receptor H2 )	0.713799	0	0
3	hsa146 ( adrenoceptor alpha 1D )	0.694074	0	0
4	hsa150 ( adrenoceptor alpha 2A )	0.6597	0	0
5	hsa147 ( adrenoceptor alpha 1B )	0.659465	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.621623	0	0
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.591201	1	1
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.547303	0	0
9	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.524805	1	1
10	hsa1812 ( dopamine receptor D1 )	0.511961	0	0

D00493 : Prochlorperazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00493 ( Prochlorperazine )

Rank	Target	Score
1	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.833031
2	hsa151 ( adrenoceptor alpha 2B )	0.76423
3	hsa148 ( adrenoceptor alpha 1A )	0.764044
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.760831
5	hsa150 ( adrenoceptor alpha 2A )	0.759111
6	hsa1815 ( dopamine receptor D4 )	0.716291
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.708577
8	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.658396
9	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.656956
10	hsa59340 ( histamine receptor H4 )	0.642441

D00494 : Promethazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00494 ( Promethazine )

Rank	Target	Score
1	hsa1812 ( dopamine receptor D1 )	0.761883
2	hsa1815 ( dopamine receptor D4 )	0.687341
3	hsa147 ( adrenoceptor alpha 1B )	0.669732
4	hsa146 ( adrenoceptor alpha 1D )	0.660697
5	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.634973
6	hsa1814 ( dopamine receptor D3 )	0.631168
7	hsa151 ( adrenoceptor alpha 2B )	0.520381
8	hsa1816 ( dopamine receptor D5 )	0.502805
9	hsa154 ( adrenoceptor beta 2 )	0.489272
10	hsa153 ( adrenoceptor beta 1 )	0.476349

D00498 : Pentazocine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00498 ( Pentazocine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa4986 ( opioid receptor kappa 1 )	0.928879	1	1	1
2	hsa4985 ( opioid receptor delta 1 )	0.842354	0	0	0
3	hsa185 ( angiotensin II receptor type 1 )	0.793012	0	0	0
4	hsa6752 ( somatostatin receptor 2 )	0.712256	0	0	0
5	hsa7201 ( thyrotropin releasing hormone receptor )	0.69011	0	0	0
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.666382	0	0	0
7	hsa6755 ( somatostatin receptor 5 )	0.663263	0	0	0
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.655593	0	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.648974	0	0	0
10	hsa6753 ( somatostatin receptor 3 )	0.616431	0	0	0

D00499 : Pentobarbital (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00499 ( Pentobarbital )

Rank	Target	Score
1	hsa338442 ( hydroxycarboxylic acid receptor 2 )	0.821125
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.80375
3	hsa185 ( angiotensin II receptor type 1 )	0.759743
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.75108
5	hsa3269 ( histamine receptor H1 )	0.722989
6	hsa1129 ( cholinergic receptor muscarinic 2 )	0.701117
7	hsa4988 ( opioid receptor mu 1 )	0.668882
8	hsa1813 ( dopamine receptor D2 )	0.648303
9	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.626523
10	hsa57105 ( cysteinyl leukotriene receptor 2 )	0.577707

D00503 : Perphenazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00503 ( Perphenazine )

Rank	Target	Score
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.923173
2	hsa147 ( adrenoceptor alpha 1B )	0.874118
3	hsa146 ( adrenoceptor alpha 1D )	0.868511
4	hsa1816 ( dopamine receptor D5 )	0.851511
5	hsa151 ( adrenoceptor alpha 2B )	0.845397
6	hsa150 ( adrenoceptor alpha 2A )	0.832341
7	hsa3269 ( histamine receptor H1 )	0.830205
8	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.686334
9	hsa152 ( adrenoceptor alpha 2C )	0.665912
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.655289

D00509 : Phentolamine mesylate (Found 7 out of 21 validated targets)

Top-10 predicted interaction for: D00509 ( Phentolamine mesylate )

Rank	Target	Score	Validated	Matador
1	hsa153 ( adrenoceptor beta 1 )	0.777971	1	1
2	hsa154 ( adrenoceptor beta 2 )	0.758215	1	1
3	hsa155 ( adrenoceptor beta 3 )	0.674138	1	1
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.648347	1	1
5	hsa1813 ( dopamine receptor D2 )	0.621097	1	1
6	hsa3274 ( histamine receptor H2 )	0.581155	0	0
7	hsa3269 ( histamine receptor H1 )	0.553646	1	1
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.509483	0	0
9	hsa185 ( angiotensin II receptor type 1 )	0.501699	0	0
10	hsa1812 ( dopamine receptor D1 )	0.474753	1	1

D00513 : Pindolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00513 ( Pindolol )

Rank	Target	Score
1	hsa152 ( adrenoceptor alpha 2C )	0.828056
2	hsa3274 ( histamine receptor H2 )	0.70862
3	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.695504
4	hsa1814 ( dopamine receptor D3 )	0.6267
5	hsa1813 ( dopamine receptor D2 )	0.59982
6	hsa1812 ( dopamine receptor D1 )	0.516658
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.49888
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.456622
9	hsa1816 ( dopamine receptor D5 )	0.408754
10	hsa3269 ( histamine receptor H1 )	0.405653

D00514 : Dexmedetomidine (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00514 ( Dexmedetomidine )

Rank	Target	Score	Validated	KEGG
1	hsa151 ( adrenoceptor alpha 2B )	0.954207	1	1
2	hsa152 ( adrenoceptor alpha 2C )	0.945606	1	1
3	hsa146 ( adrenoceptor alpha 1D )	0.832232	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.829892	0	0
5	hsa147 ( adrenoceptor alpha 1B )	0.80828	0	0
6	hsa1813 ( dopamine receptor D2 )	0.743986	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.67202	0	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.623135	0	0
9	hsa3269 ( histamine receptor H1 )	0.62126	0	0
10	hsa154 ( adrenoceptor beta 2 )	0.593274	0	0

D00520 : Dimenhydrinate (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00520 ( Dimenhydrinate )

Rank	Target	Score	Validated	Matador
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.847492	0	0
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.775697	0	0
3	hsa1813 ( dopamine receptor D2 )	0.773001	0	0
4	hsa59340 ( histamine receptor H4 )	0.768539	1	1
5	hsa11255 ( histamine receptor H3 )	0.751058	1	1
6	hsa1131 ( cholinergic receptor muscarinic 3 )	0.71681	0	0
7	hsa1812 ( dopamine receptor D1 )	0.700515	0	0
8	hsa148 ( adrenoceptor alpha 1A )	0.650048	0	0
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.643134	0	0
10	hsa3274 ( histamine receptor H2 )	0.588721	0	0

D00521 : Terfenadine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00521 ( Terfenadine )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.891539
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.841594
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.822828
4	hsa1813 ( dopamine receptor D2 )	0.758372
5	hsa59340 ( histamine receptor H4 )	0.704221
6	hsa1812 ( dopamine receptor D1 )	0.691017
7	hsa11255 ( histamine receptor H3 )	0.688738
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.6455
9	hsa148 ( adrenoceptor alpha 1A )	0.642051
10	hsa1132 ( cholinergic receptor muscarinic 4 )	0.626987

D00522 : Candesartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00522 ( Candesartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.853921
2	hsa4988 ( opioid receptor mu 1 )	0.805477
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.701036
4	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.636353
5	hsa4986 ( opioid receptor kappa 1 )	0.63224
6	hsa148 ( adrenoceptor alpha 1A )	0.618734
7	hsa64805 ( purinergic receptor P2Y12 )	0.617781
8	hsa136 ( adenosine A2b receptor )	0.617336
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.571293
10	hsa7201 ( thyrotropin releasing hormone receptor )	0.569736

D00523 : Irbesartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00523 ( Irbesartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.848686
2	hsa4988 ( opioid receptor mu 1 )	0.793444
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.683594
4	hsa148 ( adrenoceptor alpha 1A )	0.652116
5	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.648212
6	hsa4986 ( opioid receptor kappa 1 )	0.613156
7	hsa64805 ( purinergic receptor P2Y12 )	0.612528
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.593567
9	hsa136 ( adenosine A2b receptor )	0.581532
10	hsa3269 ( histamine receptor H1 )	0.579588

D00524 : Carbachol (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D00524 ( Carbachol )

Rank	Target	Score	Validated	KEGG
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.902422	1	1
2	hsa3269 ( histamine receptor H1 )	0.881591	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.836058	1	1
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.790799	1	1
5	hsa338442 ( hydroxycarboxylic acid receptor 2 )	0.683052	0	0
6	hsa1813 ( dopamine receptor D2 )	0.672273	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.652426	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.618667	0	0
9	hsa185 ( angiotensin II receptor type 1 )	0.613753	0	0
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.604022	0	0

D00525 : Pilocarpine (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00525 ( Pilocarpine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.960695	1	1	1
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.927896	1	1	1
3	hsa3269 ( histamine receptor H1 )	0.913492	0	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.848023	1	1	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.803799	1	1	0
6	hsa1813 ( dopamine receptor D2 )	0.643579	0	0	0
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.60056	0	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.59953	0	0	0
9	hsa4988 ( opioid receptor mu 1 )	0.597024	0	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.579531	0	0	0

D00528 : Caffeine (Found 0 out of 5 validated targets)

Top-10 predicted interaction for: D00528 ( Caffeine )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.921133
2	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.760175
3	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.718787
4	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.696096
5	hsa5724 ( platelet activating factor receptor )	0.689858
6	hsa57105 ( cysteinyl leukotriene receptor 2 )	0.653763
7	hsa150 ( adrenoceptor alpha 2A )	0.611485
8	hsa5731 ( prostaglandin E receptor 1 )	0.599193
9	hsa4988 ( opioid receptor mu 1 )	0.568579
10	hsa6915 ( thromboxane A2 receptor )	0.563599

D00540 : Glycopyrrolate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00540 ( Glycopyrrolate )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.957374	1	1	1
2	hsa3269 ( histamine receptor H1 )	0.927504	0	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.902056	0	0	0
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.865204	0	0	0
5	hsa1813 ( dopamine receptor D2 )	0.635752	0	0	0
6	hsa4988 ( opioid receptor mu 1 )	0.587471	0	0	0
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.574359	0	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.563301	0	0	0
9	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.560191	0	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.53958	0	0	0

D00542 : Halothane (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00542 ( Halothane )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.780517
2	hsa154 ( adrenoceptor beta 2 )	0.690143
3	hsa153 ( adrenoceptor beta 1 )	0.67656
4	hsa150 ( adrenoceptor alpha 2A )	0.662259
5	hsa4988 ( opioid receptor mu 1 )	0.617413
6	hsa136 ( adenosine A2b receptor )	0.613429
7	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.605237
8	hsa148 ( adrenoceptor alpha 1A )	0.59106
9	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.582652
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.573471

D00559 : Pramipexole hydrochloride (Found 6 out of 13 validated targets)

Top-10 predicted interaction for: D00559 ( Pramipexole hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1813 ( dopamine receptor D2 )	0.966258	1	1	1
2	hsa1812 ( dopamine receptor D1 )	0.949496	1	0	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.895385	1	0	1
4	hsa1816 ( dopamine receptor D5 )	0.845717	1	0	1
5	hsa3269 ( histamine receptor H1 )	0.790429	0	0	0
6	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.752239	1	0	1
7	hsa150 ( adrenoceptor alpha 2A )	0.708218	1	0	1
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.697125	0	0	0
9	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.679934	0	0	0
10	hsa4985 ( opioid receptor delta 1 )	0.671681	0	0	0

D00560 : Pimozide (Found 0 out of 3 validated targets)

Top-10 predicted interaction for: D00560 ( Pimozide )

Rank	Target	Score
1	hsa4988 ( opioid receptor mu 1 )	0.879989
2	hsa3269 ( histamine receptor H1 )	0.857806
3	hsa4986 ( opioid receptor kappa 1 )	0.846709
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.796905
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.65033
6	hsa1128 ( cholinergic receptor muscarinic 1 )	0.646518
7	hsa150 ( adrenoceptor alpha 2A )	0.616605
8	hsa154 ( adrenoceptor beta 2 )	0.614318
9	hsa151 ( adrenoceptor alpha 2B )	0.609026
10	hsa7201 ( thyrotropin releasing hormone receptor )	0.593008

D00563 : Mirtazapine (Found 9 out of 16 validated targets)

Top-10 predicted interaction for: D00563 ( Mirtazapine )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa1813 ( dopamine receptor D2 )	0.899508	1	0	1	0
2	hsa146 ( adrenoceptor alpha 1D )	0.869692	1	0	1	0
3	hsa152 ( adrenoceptor alpha 2C )	0.869244	1	1	1	0
4	hsa148 ( adrenoceptor alpha 1A )	0.854643	1	0	1	0
5	hsa147 ( adrenoceptor alpha 1B )	0.835786	1	0	1	0
6	hsa3269 ( histamine receptor H1 )	0.81291	1	0	1	1
7	hsa1814 ( dopamine receptor D3 )	0.806352	1	0	1	0
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.798636	0	0	0	0
9	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.773193	1	0	0	1
10	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.760519	1	1	1	0

D00574 : Aminoglutethimide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00574 ( Aminoglutethimide )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.843363
2	hsa150 ( adrenoceptor alpha 2A )	0.668721
3	hsa4988 ( opioid receptor mu 1 )	0.655186
4	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.62851
5	hsa136 ( adenosine A2b receptor )	0.626919
6	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.616874
7	hsa134 ( adenosine A1 receptor )	0.615662
8	hsa148 ( adrenoceptor alpha 1A )	0.611329
9	hsa154 ( adrenoceptor beta 2 )	0.589805
10	hsa153 ( adrenoceptor beta 1 )	0.583412

D00598 : Betaxolol hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00598 ( Betaxolol hydrochloride )

Rank	Target	Score
1	hsa155 ( adrenoceptor beta 3 )	0.936014
2	hsa148 ( adrenoceptor alpha 1A )	0.726443
3	hsa3274 ( histamine receptor H2 )	0.690512
4	hsa146 ( adrenoceptor alpha 1D )	0.601789
5	hsa150 ( adrenoceptor alpha 2A )	0.600858
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.586799
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.58464
8	hsa147 ( adrenoceptor alpha 1B )	0.567903
9	hsa151 ( adrenoceptor alpha 2B )	0.562768
10	hsa1812 ( dopamine receptor D1 )	0.536243

D00601 : Metoprolol tartrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00601 ( Metoprolol tartrate )

Rank	Target	Score
1	hsa155 ( adrenoceptor beta 3 )	0.929621
2	hsa148 ( adrenoceptor alpha 1A )	0.707338
3	hsa3274 ( histamine receptor H2 )	0.70716
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.593655
5	hsa146 ( adrenoceptor alpha 1D )	0.578331
6	hsa150 ( adrenoceptor alpha 2A )	0.569719
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.564531
8	hsa147 ( adrenoceptor alpha 1B )	0.546312
9	hsa1812 ( dopamine receptor D1 )	0.539594
10	hsa151 ( adrenoceptor alpha 2B )	0.53591

D00604 : Clonidine hydrochloride (Found 4 out of 13 validated targets)

Top-10 predicted interaction for: D00604 ( Clonidine hydrochloride )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa148 ( adrenoceptor alpha 1A )	0.955942	1	1	1
2	hsa147 ( adrenoceptor alpha 1B )	0.95287	1	1	1
3	hsa1813 ( dopamine receptor D2 )	0.698785	0	0	0
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.690697	1	0	1
5	hsa153 ( adrenoceptor beta 1 )	0.640924	0	0	0
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.614739	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.60645	0	0	0
8	hsa155 ( adrenoceptor beta 3 )	0.55249	0	0	0
9	hsa185 ( angiotensin II receptor type 1 )	0.551968	0	0	0
10	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.525401	1	0	1

D00606 : Guanfacine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00606 ( Guanfacine hydrochloride )

Rank	Target	Score
1	hsa146 ( adrenoceptor alpha 1D )	0.865459
2	hsa148 ( adrenoceptor alpha 1A )	0.844091
3	hsa147 ( adrenoceptor alpha 1B )	0.836182
4	hsa1813 ( dopamine receptor D2 )	0.712396
5	hsa154 ( adrenoceptor beta 2 )	0.662188
6	hsa153 ( adrenoceptor beta 1 )	0.647337
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.616189
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.606543
9	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.567342
10	hsa155 ( adrenoceptor beta 3 )	0.559119

D00607 : Guanadrel sulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00607 ( Guanadrel sulfate )

Rank	Target	Score
1	hsa1813 ( dopamine receptor D2 )	0.688675
2	hsa153 ( adrenoceptor beta 1 )	0.667703
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.663517
4	hsa154 ( adrenoceptor beta 2 )	0.628366
5	hsa185 ( angiotensin II receptor type 1 )	0.5803
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.566175
7	hsa155 ( adrenoceptor beta 3 )	0.55853
8	hsa3269 ( histamine receptor H1 )	0.536266
9	hsa1812 ( dopamine receptor D1 )	0.494879
10	hsa3274 ( histamine receptor H2 )	0.488897

D00609 : Prazosin hydrochloride (Found 3 out of 4 validated targets)

Top-10 predicted interaction for: D00609 ( Prazosin hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.6904	0	0
2	hsa153 ( adrenoceptor beta 1 )	0.673891	1	1
3	hsa1813 ( dopamine receptor D2 )	0.670225	0	0
4	hsa154 ( adrenoceptor beta 2 )	0.640767	1	1
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.581356	0	0
6	hsa155 ( adrenoceptor beta 3 )	0.577961	1	1
7	hsa3269 ( histamine receptor H1 )	0.573866	0	0
8	hsa185 ( angiotensin II receptor type 1 )	0.560037	0	0
9	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.543683	0	0
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.518844	0	0

D00613 : Fenoldopam mesylate (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D00613 ( Fenoldopam mesylate )

Rank	Target	Score	Validated	DrugBank
1	hsa1813 ( dopamine receptor D2 )	0.903161	0	0
2	hsa1814 ( dopamine receptor D3 )	0.844023	0	0
3	hsa154 ( adrenoceptor beta 2 )	0.826576	0	0
4	hsa153 ( adrenoceptor beta 1 )	0.775015	0	0
5	hsa148 ( adrenoceptor alpha 1A )	0.764115	1	1
6	hsa146 ( adrenoceptor alpha 1D )	0.748246	1	1
7	hsa147 ( adrenoceptor alpha 1B )	0.700416	1	1
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.659529	0	0
9	hsa155 ( adrenoceptor beta 3 )	0.638721	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.632874	0	0

D00627 : Telmisartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00627 ( Telmisartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.856951
2	hsa4988 ( opioid receptor mu 1 )	0.764359
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.686363
4	hsa148 ( adrenoceptor alpha 1A )	0.627099
5	hsa150 ( adrenoceptor alpha 2A )	0.619634
6	hsa136 ( adenosine A2b receptor )	0.617086
7	hsa64805 ( purinergic receptor P2Y12 )	0.612201
8	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.610838
9	hsa4986 ( opioid receptor kappa 1 )	0.589882
10	hsa134 ( adenosine A1 receptor )	0.570617

D00632 : Dobutamine hydrochloride (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00632 ( Dobutamine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa155 ( adrenoceptor beta 3 )	0.933105	1	1
2	hsa148 ( adrenoceptor alpha 1A )	0.694219	0	0
3	hsa3274 ( histamine receptor H2 )	0.688905	0	0
4	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.580191	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.576793	0	0
6	hsa146 ( adrenoceptor alpha 1D )	0.570589	0	0
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.570549	0	0
8	hsa1812 ( dopamine receptor D1 )	0.545276	0	0
9	hsa151 ( adrenoceptor alpha 2B )	0.54406	0	0
10	hsa147 ( adrenoceptor alpha 1B )	0.535582	0	0

D00635 : Metoprolol succinate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00635 ( Metoprolol succinate )

Rank	Target	Score
1	hsa155 ( adrenoceptor beta 3 )	0.925632
2	hsa148 ( adrenoceptor alpha 1A )	0.713984
3	hsa3274 ( histamine receptor H2 )	0.695299
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.587992
5	hsa146 ( adrenoceptor alpha 1D )	0.586997
6	hsa150 ( adrenoceptor alpha 2A )	0.586647
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.562681
8	hsa147 ( adrenoceptor alpha 1B )	0.555846
9	hsa151 ( adrenoceptor alpha 2B )	0.548807
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.536859

D00645 : Bretylium tosylate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00645 ( Bretylium tosylate )

Rank	Target	Score
1	hsa155 ( adrenoceptor beta 3 )	0.912654
2	hsa148 ( adrenoceptor alpha 1A )	0.729678
3	hsa3274 ( histamine receptor H2 )	0.706135
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.613789
5	hsa3269 ( histamine receptor H1 )	0.608091
6	hsa146 ( adrenoceptor alpha 1D )	0.599859
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.581509
8	hsa147 ( adrenoceptor alpha 1B )	0.573694
9	hsa1129 ( cholinergic receptor muscarinic 2 )	0.565417
10	hsa150 ( adrenoceptor alpha 2A )	0.557303

D00646 : Tolterodine (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D00646 ( Tolterodine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.933085	1	1	1
2	hsa3269 ( histamine receptor H1 )	0.915183	0	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.868583	1	0	1
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.824141	1	0	1
5	hsa1813 ( dopamine receptor D2 )	0.708719	0	0	0
6	hsa154 ( adrenoceptor beta 2 )	0.682228	0	0	0
7	hsa153 ( adrenoceptor beta 1 )	0.609409	0	0	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.601049	0	0	0
9	hsa1812 ( dopamine receptor D1 )	0.600985	0	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.581593	0	0	0

D00665 : Chlorpheniramine maleate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00665 ( Chlorpheniramine maleate )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.8548
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.790272
3	hsa1813 ( dopamine receptor D2 )	0.774311
4	hsa1131 ( cholinergic receptor muscarinic 3 )	0.722329
5	hsa1812 ( dopamine receptor D1 )	0.707972
6	hsa59340 ( histamine receptor H4 )	0.707267
7	hsa11255 ( histamine receptor H3 )	0.68464
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.665068
9	hsa148 ( adrenoceptor alpha 1A )	0.629175
10	hsa23620 ( neurotensin receptor 2 )	0.594819

D00666 : Clemastine fumarate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00666 ( Clemastine fumarate )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.862692
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.797908
3	hsa59340 ( histamine receptor H4 )	0.763744
4	hsa11255 ( histamine receptor H3 )	0.754593
5	hsa1131 ( cholinergic receptor muscarinic 3 )	0.736104
6	hsa1813 ( dopamine receptor D2 )	0.72604
7	hsa23620 ( neurotensin receptor 2 )	0.666441
8	hsa1812 ( dopamine receptor D1 )	0.645641
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.628837
10	hsa148 ( adrenoceptor alpha 1A )	0.620517

D00673 : Ranitidine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00673 ( Ranitidine hydrochloride )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.860915
2	hsa153 ( adrenoceptor beta 1 )	0.836698
3	hsa148 ( adrenoceptor alpha 1A )	0.735631
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.707041
5	hsa155 ( adrenoceptor beta 3 )	0.705088
6	hsa3269 ( histamine receptor H1 )	0.689883
7	hsa59340 ( histamine receptor H4 )	0.667448
8	hsa136 ( adenosine A2b receptor )	0.651629
9	hsa147 ( adrenoceptor alpha 1B )	0.609979
10	hsa146 ( adrenoceptor alpha 1D )	0.601565

D00674 : Naratriptan hydrochloride (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00674 ( Naratriptan hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.962189	1	1	1	1
2	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.962071	1	1	1	1
3	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.915806	1	1	1	0
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.914331	0	0	0	0
5	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.871943	1	1	0	0
6	hsa148 ( adrenoceptor alpha 1A )	0.871001	0	0	0	0
7	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.848679	0	0	0	0
8	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.843333	0	0	0	0
9	hsa1814 ( dopamine receptor D3 )	0.832357	0	0	0	0
10	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.830402	0	0	0	0

D00675 : Rizatriptan benzoate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00675 ( Rizatriptan benzoate )

Rank	Target	Score	Validated	DrugBank
1	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.963256	1	1
2	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.904425	0	0
3	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.868935	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.850127	0	0
5	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.841225	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.825977	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.81632	0	0
8	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.815904	0	0
9	hsa1814 ( dopamine receptor D3 )	0.803663	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.801089	0	0

D00676 : Sumatriptan succinate (Found 7 out of 8 validated targets)

Top-10 predicted interaction for: D00676 ( Sumatriptan succinate )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.911378	1	1	1
2	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.886108	1	0	1
3	hsa148 ( adrenoceptor alpha 1A )	0.875553	0	0	0
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.870016	1	0	1
5	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.855138	1	0	1
6	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.837723	1	0	1
7	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.832197	1	0	1
8	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.804595	0	0	0
9	hsa1814 ( dopamine receptor D3 )	0.795336	0	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.77633	1	0	1

D00682 : Carboprost tromethamine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00682 ( Carboprost tromethamine )

Rank	Target	Score	Validated	KEGG
1	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.950861	0	0
2	hsa5733 ( prostaglandin E receptor 3 )	0.933167	0	0
3	hsa5732 ( prostaglandin E receptor 2 )	0.919303	0	0
4	hsa5737 ( prostaglandin F receptor )	0.91072	1	1
5	hsa6915 ( thromboxane A2 receptor )	0.824597	0	0
6	hsa4988 ( opioid receptor mu 1 )	0.726076	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.639891	0	0
8	hsa153 ( adrenoceptor beta 1 )	0.635386	0	0
9	hsa64805 ( purinergic receptor P2Y12 )	0.624198	0	0
10	hsa3274 ( histamine receptor H2 )	0.612436	0	0

D00683 : Albuterol sulfate (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00683 ( Albuterol sulfate )

Rank	Target	Score	Validated	Matador
1	hsa153 ( adrenoceptor beta 1 )	0.970031	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.92092	1	1
3	hsa3274 ( histamine receptor H2 )	0.68762	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.68488	0	0
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.666269	0	0
6	hsa1812 ( dopamine receptor D1 )	0.599536	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.584033	0	0
8	hsa146 ( adrenoceptor alpha 1D )	0.568562	0	0
9	hsa3269 ( histamine receptor H1 )	0.567135	0	0
10	hsa151 ( adrenoceptor alpha 2B )	0.549892	0	0

D00684 : Bitolterol mesylate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00684 ( Bitolterol mesylate )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.963452
2	hsa155 ( adrenoceptor beta 3 )	0.909642
3	hsa3274 ( histamine receptor H2 )	0.693473
4	hsa148 ( adrenoceptor alpha 1A )	0.678037
5	hsa150 ( adrenoceptor alpha 2A )	0.656968
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.653754
7	hsa151 ( adrenoceptor alpha 2B )	0.614663
8	hsa1812 ( dopamine receptor D1 )	0.606412
9	hsa3269 ( histamine receptor H1 )	0.604003
10	hsa146 ( adrenoceptor alpha 1D )	0.57732

D00687 : Salmeterol xinafoate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00687 ( Salmeterol xinafoate )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.966978
2	hsa155 ( adrenoceptor beta 3 )	0.915565
3	hsa148 ( adrenoceptor alpha 1A )	0.719421
4	hsa3274 ( histamine receptor H2 )	0.66866
5	hsa150 ( adrenoceptor alpha 2A )	0.664851
6	hsa151 ( adrenoceptor alpha 2B )	0.631794
7	hsa146 ( adrenoceptor alpha 1D )	0.615008
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.603981
9	hsa147 ( adrenoceptor alpha 1B )	0.578119
10	hsa1812 ( dopamine receptor D1 )	0.57165

D00688 : Terbutaline sulfate (Found 5 out of 7 validated targets)

Top-10 predicted interaction for: D00688 ( Terbutaline sulfate )

Rank	Target	Score	Validated	Matador
1	hsa153 ( adrenoceptor beta 1 )	0.969168	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.916582	1	1
3	hsa3274 ( histamine receptor H2 )	0.706756	0	0
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.659649	0	0
5	hsa148 ( adrenoceptor alpha 1A )	0.657436	1	1
6	hsa1812 ( dopamine receptor D1 )	0.59679	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.563508	1	1
8	hsa3269 ( histamine receptor H1 )	0.54782	0	0
9	hsa146 ( adrenoceptor alpha 1D )	0.536988	1	1
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.536575	0	0

D00715 : Methscopolamine bromide (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00715 ( Methscopolamine bromide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.970697	1	1	1
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.946357	1	1	1
3	hsa3269 ( histamine receptor H1 )	0.910485	0	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.883947	1	1	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.844804	1	1	0
6	hsa1813 ( dopamine receptor D2 )	0.65938	0	0	0
7	hsa4988 ( opioid receptor mu 1 )	0.633845	0	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.570593	0	0	0
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.564866	0	0	0
10	hsa185 ( angiotensin II receptor type 1 )	0.544206	0	0	0

D00726 : Metoclopramide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00726 ( Metoclopramide )

Rank	Target	Score	Validated	Matador
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.83953	1	1
2	hsa3269 ( histamine receptor H1 )	0.775923	0	0
3	hsa1812 ( dopamine receptor D1 )	0.765997	0	0
4	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.70958	0	0
5	hsa148 ( adrenoceptor alpha 1A )	0.708771	0	0
6	hsa154 ( adrenoceptor beta 2 )	0.685471	0	0
7	hsa1131 ( cholinergic receptor muscarinic 3 )	0.674309	0	0
8	hsa150 ( adrenoceptor alpha 2A )	0.673733	0	0
9	hsa153 ( adrenoceptor beta 1 )	0.611148	0	0
10	hsa1815 ( dopamine receptor D4 )	0.579572	0	0

D00760 : Doxacurium chloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00760 ( Doxacurium chloride )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.977996
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.943992
3	hsa3269 ( histamine receptor H1 )	0.876742
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.873866
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.824921
6	hsa4988 ( opioid receptor mu 1 )	0.613125
7	hsa1813 ( dopamine receptor D2 )	0.603983
8	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.582798
9	hsa148 ( adrenoceptor alpha 1A )	0.571429
10	hsa154 ( adrenoceptor beta 2 )	0.563276

D00765 : Rocuronium bromide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00765 ( Rocuronium bromide )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.976455
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.940005
3	hsa3269 ( histamine receptor H1 )	0.902971
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.863937
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.814258
6	hsa4988 ( opioid receptor mu 1 )	0.624487
7	hsa185 ( angiotensin II receptor type 1 )	0.595638
8	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.582784
9	hsa1813 ( dopamine receptor D2 )	0.569966
10	hsa154 ( adrenoceptor beta 2 )	0.564927

D00769 : Clopidogrel bisulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00769 ( Clopidogrel bisulfate )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.699656
2	hsa185 ( angiotensin II receptor type 1 )	0.68733
3	hsa1813 ( dopamine receptor D2 )	0.686567
4	hsa3269 ( histamine receptor H1 )	0.685414
5	hsa4988 ( opioid receptor mu 1 )	0.65682
6	hsa1812 ( dopamine receptor D1 )	0.654745
7	hsa136 ( adenosine A2b receptor )	0.650757
8	hsa134 ( adenosine A1 receptor )	0.650416
9	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.636781
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.633911

D00775 : Riluzole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00775 ( Riluzole )

Rank	Target	Score
1	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.87327
2	hsa154 ( adrenoceptor beta 2 )	0.716993
3	hsa153 ( adrenoceptor beta 1 )	0.658076
4	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.625812
5	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.621246
6	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.620787
7	hsa6010 ( rhodopsin )	0.606558
8	hsa3269 ( histamine receptor H1 )	0.599893
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.598775
10	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.595237

D00779 : Biperiden (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D00779 ( Biperiden )

Rank	Target	Score	Validated	KEGG
1	hsa1131 ( cholinergic receptor muscarinic 3 )	0.951412	1	1
2	hsa3269 ( histamine receptor H1 )	0.908781	0	0
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.893401	1	1
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.852485	1	1
5	hsa1813 ( dopamine receptor D2 )	0.646072	0	0
6	hsa4988 ( opioid receptor mu 1 )	0.625053	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.591949	0	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.559048	0	0
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.552503	0	0
10	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.546753	0	0

D00780 : Bromocriptine mesylate (Found 8 out of 17 validated targets)

Top-10 predicted interaction for: D00780 ( Bromocriptine mesylate )

Rank	Target	Score	Validated	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.923169	1	1
2	hsa1812 ( dopamine receptor D1 )	0.914963	1	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.854911	1	1
4	hsa3269 ( histamine receptor H1 )	0.77611	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.771526	1	1
6	hsa1816 ( dopamine receptor D5 )	0.754706	1	1
7	hsa151 ( adrenoceptor alpha 2B )	0.743034	1	1
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.722793	0	0
9	hsa148 ( adrenoceptor alpha 1A )	0.716963	1	1
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.635232	1	1

D00790 : Chlorprothixene (Found 5 out of 10 validated targets)

Top-10 predicted interaction for: D00790 ( Chlorprothixene )

Rank	Target	Score	Validated	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.943023	1	1
2	hsa1816 ( dopamine receptor D5 )	0.885294	0	0
3	hsa3269 ( histamine receptor H1 )	0.873708	1	1
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.865398	1	1
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.747855	1	1
6	hsa151 ( adrenoceptor alpha 2B )	0.723079	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.722739	0	0
8	hsa148 ( adrenoceptor alpha 1A )	0.718386	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.680246	0	0
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.650973	1	1

D00837 : Butorphanol tartrate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00837 ( Butorphanol tartrate )

Rank	Target	Score	Validated	DrugBank
1	hsa4985 ( opioid receptor delta 1 )	0.905627	1	1
2	hsa185 ( angiotensin II receptor type 1 )	0.812587	0	0
3	hsa7201 ( thyrotropin releasing hormone receptor )	0.788204	0	0
4	hsa6752 ( somatostatin receptor 2 )	0.712584	0	0
5	hsa1812 ( dopamine receptor D1 )	0.701032	0	0
6	hsa6755 ( somatostatin receptor 5 )	0.696689	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.668931	0	0
8	hsa6753 ( somatostatin receptor 3 )	0.651669	0	0
9	hsa1814 ( dopamine receptor D3 )	0.635285	0	0
10	hsa154 ( adrenoceptor beta 2 )	0.628804	0	0

D00838 : Dezocine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00838 ( Dezocine )

Rank	Target	Score	Validated	KEGG
1	hsa4985 ( opioid receptor delta 1 )	0.912646	1	1
2	hsa185 ( angiotensin II receptor type 1 )	0.811835	0	0
3	hsa7201 ( thyrotropin releasing hormone receptor )	0.759242	0	0
4	hsa6752 ( somatostatin receptor 2 )	0.742946	0	0
5	hsa6755 ( somatostatin receptor 5 )	0.716465	0	0
6	hsa1812 ( dopamine receptor D1 )	0.715989	0	0
7	hsa6753 ( somatostatin receptor 3 )	0.674666	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.656739	0	0
9	hsa1814 ( dopamine receptor D3 )	0.654708	0	0
10	hsa6751 ( somatostatin receptor 1 )	0.633151	0	0

D00845 : Sufentanil citrate (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00845 ( Sufentanil citrate )

Rank	Target	Score	Validated	DrugBank
1	hsa4986 ( opioid receptor kappa 1 )	0.920279	1	1
2	hsa4985 ( opioid receptor delta 1 )	0.831269	1	1
3	hsa185 ( angiotensin II receptor type 1 )	0.795161	0	0
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.738616	0	0
5	hsa6752 ( somatostatin receptor 2 )	0.696296	0	0
6	hsa1129 ( cholinergic receptor muscarinic 2 )	0.690536	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.689729	0	0
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.682195	0	0
9	hsa6755 ( somatostatin receptor 5 )	0.650575	0	0
10	hsa3269 ( histamine receptor H1 )	0.650007	0	0

D00954 : Norgestrel (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00954 ( Norgestrel )

Rank	Target	Score
1	hsa147 ( adrenoceptor alpha 1B )	0.934703
2	hsa146 ( adrenoceptor alpha 1D )	0.924854
3	hsa153 ( adrenoceptor beta 1 )	0.756858
4	hsa150 ( adrenoceptor alpha 2A )	0.742522
5	hsa151 ( adrenoceptor alpha 2B )	0.739879
6	hsa154 ( adrenoceptor beta 2 )	0.699726
7	hsa3269 ( histamine receptor H1 )	0.696951
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.680626
9	hsa185 ( angiotensin II receptor type 1 )	0.679286
10	hsa3274 ( histamine receptor H2 )	0.660071

D00965 : Nilutamide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00965 ( Nilutamide )

Rank	Target	Score
1	hsa147 ( adrenoceptor alpha 1B )	0.947205
2	hsa146 ( adrenoceptor alpha 1D )	0.943256
3	hsa153 ( adrenoceptor beta 1 )	0.835199
4	hsa150 ( adrenoceptor alpha 2A )	0.802961
5	hsa151 ( adrenoceptor alpha 2B )	0.797979
6	hsa154 ( adrenoceptor beta 2 )	0.794328
7	hsa3274 ( histamine receptor H2 )	0.738877
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.708715
9	hsa155 ( adrenoceptor beta 3 )	0.705628
10	hsa152 ( adrenoceptor alpha 2C )	0.69616

D00987 : Cabergoline (Found 8 out of 19 validated targets)

Top-10 predicted interaction for: D00987 ( Cabergoline )

Rank	Target	Score	Validated	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.921395	1	1
2	hsa1812 ( dopamine receptor D1 )	0.900466	1	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.884298	1	1
4	hsa150 ( adrenoceptor alpha 2A )	0.797596	1	1
5	hsa3269 ( histamine receptor H1 )	0.769183	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.76531	1	1
7	hsa148 ( adrenoceptor alpha 1A )	0.759873	1	1
8	hsa1816 ( dopamine receptor D5 )	0.732298	1	1
9	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.696953	1	1
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.687898	0	0

D00996 : Epinephrine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00996 ( Epinephrine hydrochloride )

Rank	Target	Score
1	hsa3274 ( histamine receptor H2 )	0.620536
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.563099
3	hsa1813 ( dopamine receptor D2 )	0.483776
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.482902
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.428238
6	hsa1812 ( dopamine receptor D1 )	0.418888
7	hsa185 ( angiotensin II receptor type 1 )	0.40996
8	hsa3269 ( histamine receptor H1 )	0.407292
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.404272
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.396784

D01020 : Methoxamine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01020 ( Methoxamine hydrochloride )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.889926
2	hsa154 ( adrenoceptor beta 2 )	0.869782
3	hsa151 ( adrenoceptor alpha 2B )	0.86937
4	hsa150 ( adrenoceptor alpha 2A )	0.868567
5	hsa155 ( adrenoceptor beta 3 )	0.802633
6	hsa152 ( adrenoceptor alpha 2C )	0.794251
7	hsa3274 ( histamine receptor H2 )	0.687241
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.661762
9	hsa3269 ( histamine receptor H1 )	0.57058
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.551476

D01022 : Oxymetazoline hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01022 ( Oxymetazoline hydrochloride )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.768873
2	hsa154 ( adrenoceptor beta 2 )	0.736524
3	hsa155 ( adrenoceptor beta 3 )	0.676959
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.640957
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.614079
6	hsa1813 ( dopamine receptor D2 )	0.607076
7	hsa185 ( angiotensin II receptor type 1 )	0.579179
8	hsa3274 ( histamine receptor H2 )	0.563501
9	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.468885
10	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.464976

D01024 : Tamsulosin hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01024 ( Tamsulosin hydrochloride )

Rank	Target	Score
1	hsa151 ( adrenoceptor alpha 2B )	0.861613
2	hsa150 ( adrenoceptor alpha 2A )	0.849721
3	hsa152 ( adrenoceptor alpha 2C )	0.765875
4	hsa3269 ( histamine receptor H1 )	0.759001
5	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.75097
6	hsa1128 ( cholinergic receptor muscarinic 1 )	0.723176
7	hsa153 ( adrenoceptor beta 1 )	0.721165
8	hsa154 ( adrenoceptor beta 2 )	0.674254
9	hsa1129 ( cholinergic receptor muscarinic 2 )	0.656262
10	hsa3274 ( histamine receptor H2 )	0.6412

D01051 : Spiperone (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01051 ( Spiperone )

Rank	Target	Score	Validated	KEGG
1	hsa150 ( adrenoceptor alpha 2A )	0.8861	0	0
2	hsa151 ( adrenoceptor alpha 2B )	0.873809	0	0
3	hsa1813 ( dopamine receptor D2 )	0.863074	1	1
4	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.862814	0	0
5	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.818818	0	0
6	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.805534	0	0
7	hsa1814 ( dopamine receptor D3 )	0.805388	0	0
8	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.797451	0	0
9	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.793748	0	0
10	hsa152 ( adrenoceptor alpha 2C )	0.775713	0	0

D01071 : Hexobarbital (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01071 ( Hexobarbital )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.833094
2	hsa4988 ( opioid receptor mu 1 )	0.6678
3	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.642007
4	hsa154 ( adrenoceptor beta 2 )	0.628665
5	hsa136 ( adenosine A2b receptor )	0.626297
6	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.619061
7	hsa153 ( adrenoceptor beta 1 )	0.618093
8	hsa134 ( adenosine A1 receptor )	0.599919
9	hsa150 ( adrenoceptor alpha 2A )	0.595193
10	hsa7201 ( thyrotropin releasing hormone receptor )	0.587579

D01103 : Trospium chloride (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D01103 ( Trospium chloride )

Rank	Target	Score	Validated	KEGG	Matador
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.973383	1	1	1
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.952886	1	1	0
3	hsa3269 ( histamine receptor H1 )	0.905465	0	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.890166	1	1	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.849949	1	1	0
6	hsa1813 ( dopamine receptor D2 )	0.609023	0	0	0
7	hsa4988 ( opioid receptor mu 1 )	0.586773	0	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.583119	0	0	0
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.559448	0	0	0
10	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.557749	0	0	0

D01118 : Profenamine hydrochloride (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D01118 ( Profenamine hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.960795	1	1	1
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.931172	1	1	0
3	hsa3269 ( histamine receptor H1 )	0.923565	0	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.86275	1	1	0
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.822739	1	1	0
6	hsa1813 ( dopamine receptor D2 )	0.736869	0	0	0
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.65479	0	0	0
8	hsa148 ( adrenoceptor alpha 1A )	0.609389	0	0	0
9	hsa11255 ( histamine receptor H3 )	0.577588	0	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.56913	0	0	0

D01126 : Arginine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01126 ( Arginine hydrochloride )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.762056
2	hsa2918 ( glutamate metabotropic receptor 8 )	0.678176
3	hsa185 ( angiotensin II receptor type 1 )	0.669887
4	hsa154 ( adrenoceptor beta 2 )	0.649546
5	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.640651
6	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.615873
7	hsa148 ( adrenoceptor alpha 1A )	0.605075
8	hsa150 ( adrenoceptor alpha 2A )	0.604692
9	hsa3274 ( histamine receptor H2 )	0.604389
10	hsa153 ( adrenoceptor beta 1 )	0.601067

D01164 : Aripiprazole (Found 8 out of 19 validated targets)

Top-10 predicted interaction for: D01164 ( Aripiprazole )

Rank	Target	Score	Validated	DrugBank
1	hsa1812 ( dopamine receptor D1 )	0.928113	1	1
2	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.859002	0	0
3	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.84571	1	1
4	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.837384	1	1
5	hsa150 ( adrenoceptor alpha 2A )	0.829092	1	1
6	hsa151 ( adrenoceptor alpha 2B )	0.788604	1	1
7	hsa3269 ( histamine receptor H1 )	0.77496	1	1
8	hsa1816 ( dopamine receptor D5 )	0.774782	1	1
9	hsa148 ( adrenoceptor alpha 1A )	0.765827	1	1
10	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.764548	0	0

D01227 : Bosentan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01227 ( Bosentan )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.766246
2	hsa185 ( angiotensin II receptor type 1 )	0.710853
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.698092
4	hsa4988 ( opioid receptor mu 1 )	0.666204
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.614188
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.613384
7	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.606784
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.60669
9	hsa5724 ( platelet activating factor receptor )	0.606295
10	hsa3274 ( histamine receptor H2 )	0.598436

D01236 : Conivaptan hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01236 ( Conivaptan hydrochloride )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.742888
2	hsa185 ( angiotensin II receptor type 1 )	0.730347
3	hsa4988 ( opioid receptor mu 1 )	0.724341
4	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.701949
5	hsa3274 ( histamine receptor H2 )	0.699818
6	hsa153 ( adrenoceptor beta 1 )	0.680518
7	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.676864
8	hsa1813 ( dopamine receptor D2 )	0.619923
9	hsa4986 ( opioid receptor kappa 1 )	0.589258
10	hsa1812 ( dopamine receptor D1 )	0.578293

D01242 : Promethazine teoclate (Found 9 out of 10 validated targets)

Top-10 predicted interaction for: D01242 ( Promethazine teoclate )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.899522	1	1	1
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.849584	1	1	1
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.807353	1	1	0
4	hsa1813 ( dopamine receptor D2 )	0.753303	1	1	0
5	hsa59340 ( histamine receptor H4 )	0.738237	1	0	1
6	hsa11255 ( histamine receptor H3 )	0.726994	1	0	1
7	hsa148 ( adrenoceptor alpha 1A )	0.670856	1	1	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.665423	1	1	0
9	hsa1812 ( dopamine receptor D1 )	0.65804	0	0	0
10	hsa1132 ( cholinergic receptor muscarinic 4 )	0.645289	1	1	0

D01269 : Solifenacin succinate (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D01269 ( Solifenacin succinate )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.96731	1	0	1
2	hsa3269 ( histamine receptor H1 )	0.939992	0	0	0
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.936917	1	1	1
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.866762	1	0	1
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.824981	1	0	1
6	hsa1813 ( dopamine receptor D2 )	0.638544	0	0	0
7	hsa11255 ( histamine receptor H3 )	0.61553	0	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.576294	0	0	0
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.560292	0	0	0
10	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.555832	0	0	0

D01295 : Cinnarizine (Found 3 out of 5 validated targets)

Top-10 predicted interaction for: D01295 ( Cinnarizine )

Rank	Target	Score	Validated	DrugBank
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.847495	0	0
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.801234	1	1
3	hsa1129 ( cholinergic receptor muscarinic 2 )	0.710925	1	1
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.704307	0	0
5	hsa4985 ( opioid receptor delta 1 )	0.661004	0	0
6	hsa154 ( adrenoceptor beta 2 )	0.654253	0	0
7	hsa148 ( adrenoceptor alpha 1A )	0.64478	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.637285	0	0
9	hsa151 ( adrenoceptor alpha 2B )	0.635336	0	0
10	hsa1131 ( cholinergic receptor muscarinic 3 )	0.629288	1	1

D01297 : Pirenzepine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01297 ( Pirenzepine hydrochloride )

Rank	Target	Score
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.957124
2	hsa3269 ( histamine receptor H1 )	0.929326
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.917792
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.851067
5	hsa1813 ( dopamine receptor D2 )	0.811203
6	hsa1133 ( cholinergic receptor muscarinic 5 )	0.810383
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.783838
8	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.669098
9	hsa1812 ( dopamine receptor D1 )	0.65624
10	hsa148 ( adrenoceptor alpha 1A )	0.646945

D01324 : Mequitazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01324 ( Mequitazine )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.873071
2	hsa1813 ( dopamine receptor D2 )	0.828894
3	hsa1129 ( cholinergic receptor muscarinic 2 )	0.813313
4	hsa1812 ( dopamine receptor D1 )	0.768141
5	hsa1131 ( cholinergic receptor muscarinic 3 )	0.762775
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.746805
7	hsa59340 ( histamine receptor H4 )	0.718036
8	hsa11255 ( histamine receptor H3 )	0.685342
9	hsa148 ( adrenoceptor alpha 1A )	0.655898
10	hsa1814 ( dopamine receptor D3 )	0.643222

D01332 : Ketotifen fumarate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01332 ( Ketotifen fumarate )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.876814
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.816596
3	hsa1813 ( dopamine receptor D2 )	0.776793
4	hsa1131 ( cholinergic receptor muscarinic 3 )	0.760198
5	hsa59340 ( histamine receptor H4 )	0.732886
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.719332
7	hsa11255 ( histamine receptor H3 )	0.699823
8	hsa1812 ( dopamine receptor D1 )	0.69023
9	hsa148 ( adrenoceptor alpha 1A )	0.670673
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.600307

D01346 : Bentiromide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01346 ( Bentiromide )

Rank	Target	Score
1	hsa2913 ( glutamate metabotropic receptor 3 )	0.904283
2	hsa2916 ( glutamate metabotropic receptor 6 )	0.897619
3	hsa2912 ( glutamate metabotropic receptor 2 )	0.892631
4	hsa2914 ( glutamate metabotropic receptor 4 )	0.833576
5	hsa2917 ( glutamate metabotropic receptor 7 )	0.826392
6	hsa3269 ( histamine receptor H1 )	0.792942
7	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.751659
8	hsa2911 ( glutamate metabotropic receptor 1 )	0.735081
9	hsa2915 ( glutamate metabotropic receptor 5 )	0.725403
10	hsa4988 ( opioid receptor mu 1 )	0.694157

D01352 : Dinoprost tromethamine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01352 ( Dinoprost tromethamine )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.963145
2	hsa5733 ( prostaglandin E receptor 3 )	0.890986
3	hsa5732 ( prostaglandin E receptor 2 )	0.890153
4	hsa6915 ( thromboxane A2 receptor )	0.858476
5	hsa64805 ( purinergic receptor P2Y12 )	0.735477
6	hsa154 ( adrenoceptor beta 2 )	0.664232
7	hsa4988 ( opioid receptor mu 1 )	0.654624
8	hsa153 ( adrenoceptor beta 1 )	0.644453
9	hsa5729 ( prostaglandin D2 receptor )	0.61173
10	hsa3269 ( histamine receptor H1 )	0.596686

D01358 : Mianserin hydrochloride (Found 8 out of 17 validated targets)

Top-10 predicted interaction for: D01358 ( Mianserin hydrochloride )

Rank	Target	Score	Validated	KEGG	Matador
1	hsa151 ( adrenoceptor alpha 2B )	0.887438	1	1	0
2	hsa150 ( adrenoceptor alpha 2A )	0.871945	1	1	0
3	hsa3269 ( histamine receptor H1 )	0.800501	1	0	1
4	hsa1813 ( dopamine receptor D2 )	0.774501	1	0	1
5	hsa152 ( adrenoceptor alpha 2C )	0.757171	1	1	0
6	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.755962	1	1	1
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.737958	0	0	0
8	hsa153 ( adrenoceptor beta 1 )	0.673515	1	0	1
9	hsa3274 ( histamine receptor H2 )	0.662934	0	0	0
10	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.662827	1	1	1

D01386 : Ephedrine hydrochloride (Found 7 out of 8 validated targets)

Top-10 predicted interaction for: D01386 ( Ephedrine hydrochloride )

Rank	Target	Score	Validated	KEGG
1	hsa153 ( adrenoceptor beta 1 )	0.967098	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.917892	1	1
3	hsa148 ( adrenoceptor alpha 1A )	0.749948	1	1
4	hsa3274 ( histamine receptor H2 )	0.668107	0	0
5	hsa146 ( adrenoceptor alpha 1D )	0.653508	1	1
6	hsa150 ( adrenoceptor alpha 2A )	0.650215	1	1
7	hsa151 ( adrenoceptor alpha 2B )	0.62088	1	1
8	hsa147 ( adrenoceptor alpha 1B )	0.620743	1	1
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.601842	0	0
10	hsa1812 ( dopamine receptor D1 )	0.569061	0	0

D01390 : Isoproterenol hydrochloride (Found 1 out of 16 validated targets)

Top-10 predicted interaction for: D01390 ( Isoproterenol hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa148 ( adrenoceptor alpha 1A )	0.772334	0	0
2	hsa3274 ( histamine receptor H2 )	0.727913	0	0
3	hsa146 ( adrenoceptor alpha 1D )	0.667414	0	0
4	hsa150 ( adrenoceptor alpha 2A )	0.648736	0	0
5	hsa147 ( adrenoceptor alpha 1B )	0.630251	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.614376	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.551931	0	0
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.543908	0	0
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.513777	1	1
10	hsa1812 ( dopamine receptor D1 )	0.510021	0	0

D01441 : Imatinib mesylate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01441 ( Imatinib mesylate )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.818763
2	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.717551
3	hsa1128 ( cholinergic receptor muscarinic 1 )	0.709742
4	hsa185 ( angiotensin II receptor type 1 )	0.68796
5	hsa1129 ( cholinergic receptor muscarinic 2 )	0.641779
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.64021
7	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.638913
8	hsa4988 ( opioid receptor mu 1 )	0.627241
9	hsa154 ( adrenoceptor beta 2 )	0.597318
10	hsa7201 ( thyrotropin releasing hormone receptor )	0.582259

D01454 : Bupranolol hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01454 ( Bupranolol hydrochloride )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.773694
2	hsa3274 ( histamine receptor H2 )	0.716675
3	hsa146 ( adrenoceptor alpha 1D )	0.663485
4	hsa147 ( adrenoceptor alpha 1B )	0.627452
5	hsa150 ( adrenoceptor alpha 2A )	0.611691
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.593178
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.579937
8	hsa151 ( adrenoceptor alpha 2B )	0.574645
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.529097
10	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.51487

D01462 : Lisuride maleate (Found 7 out of 13 validated targets)

Top-10 predicted interaction for: D01462 ( Lisuride maleate )

Rank	Target	Score	Validated	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.907228	1	1
2	hsa1812 ( dopamine receptor D1 )	0.90315	1	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.873876	1	1
4	hsa3269 ( histamine receptor H1 )	0.8435	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.782033	1	1
6	hsa151 ( adrenoceptor alpha 2B )	0.756404	1	1
7	hsa1816 ( dopamine receptor D5 )	0.748937	1	1
8	hsa148 ( adrenoceptor alpha 1A )	0.747962	0	0
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.725716	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.649338	1	1

D01603 : Bethanidine sulfate (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D01603 ( Bethanidine sulfate )

Rank	Target	Score	Validated	DrugBank
1	hsa153 ( adrenoceptor beta 1 )	0.742386	1	1
2	hsa154 ( adrenoceptor beta 2 )	0.711142	1	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.681888	0	0
4	hsa155 ( adrenoceptor beta 3 )	0.63929	1	1
5	hsa1813 ( dopamine receptor D2 )	0.63217	0	0
6	hsa3274 ( histamine receptor H2 )	0.576928	0	0
7	hsa3269 ( histamine receptor H1 )	0.576783	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.543723	0	0
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.522139	0	0
10	hsa185 ( angiotensin II receptor type 1 )	0.513244	0	0

D01652 : Apafant (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01652 ( Apafant )

Rank	Target	Score
1	hsa64805 ( purinergic receptor P2Y12 )	0.696511
2	hsa154 ( adrenoceptor beta 2 )	0.696317
3	hsa185 ( angiotensin II receptor type 1 )	0.682561
4	hsa3269 ( histamine receptor H1 )	0.676109
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.664808
6	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.657322
7	hsa153 ( adrenoceptor beta 1 )	0.648814
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.64087
9	hsa1813 ( dopamine receptor D2 )	0.634154
10	hsa6915 ( thromboxane A2 receptor )	0.603913

D01692 : Alfuzosin hydrochloride (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D01692 ( Alfuzosin hydrochloride )

Rank	Target	Score	Validated	DrugBank
1	hsa147 ( adrenoceptor alpha 1B )	0.94634	1	1
2	hsa146 ( adrenoceptor alpha 1D )	0.941159	1	1
3	hsa150 ( adrenoceptor alpha 2A )	0.824826	0	0
4	hsa151 ( adrenoceptor alpha 2B )	0.81169	0	0
5	hsa153 ( adrenoceptor beta 1 )	0.751631	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.734563	0	0
7	hsa152 ( adrenoceptor alpha 2C )	0.733915	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.708712	0	0
9	hsa3269 ( histamine receptor H1 )	0.674974	0	0
10	hsa3274 ( histamine receptor H2 )	0.661772	0	0

D01699 : Darifenacin hydrobromide (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D01699 ( Darifenacin hydrobromide )

Rank	Target	Score	Validated	DrugBank
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.975956	1	1
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.964707	1	1
3	hsa3269 ( histamine receptor H1 )	0.92696	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.878398	1	1
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.846795	1	1
6	hsa1813 ( dopamine receptor D2 )	0.65681	0	0
7	hsa4988 ( opioid receptor mu 1 )	0.612496	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.590117	0	0
9	hsa148 ( adrenoceptor alpha 1A )	0.583836	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.576109	0	0

D01712 : Theophylline sodium acetate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01712 ( Theophylline sodium acetate )

Rank	Target	Score	Validated	DrugBank
1	hsa136 ( adenosine A2b receptor )	0.964312	1	1
2	hsa140 ( adenosine A3 receptor )	0.942932	0	0
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.838086	0	0
4	hsa64805 ( purinergic receptor P2Y12 )	0.77283	0	0
5	hsa185 ( angiotensin II receptor type 1 )	0.768623	0	0
6	hsa150 ( adrenoceptor alpha 2A )	0.671507	0	0
7	hsa5029 ( purinergic receptor P2Y2 )	0.637303	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.635815	0	0
9	hsa10161 ( lysophosphatidic acid receptor 6 )	0.614651	0	0
10	hsa5031 ( pyrimidinergic receptor P2Y6 )	0.609895	0	0

D01713 : Epinastine hydrochloride (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D01713 ( Epinastine hydrochloride )

Rank	Target	Score
1	hsa1813 ( dopamine receptor D2 )	0.794496
2	hsa152 ( adrenoceptor alpha 2C )	0.785882
3	hsa153 ( adrenoceptor beta 1 )	0.756924
4	hsa154 ( adrenoceptor beta 2 )	0.740824
5	hsa1812 ( dopamine receptor D1 )	0.700652
6	hsa59340 ( histamine receptor H4 )	0.644274
7	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.635811
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.629858
9	hsa155 ( adrenoceptor beta 3 )	0.628854
10	hsa1814 ( dopamine receptor D3 )	0.614838

D01717 : Levocabastine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01717 ( Levocabastine hydrochloride )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.841436
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.77355
3	hsa11255 ( histamine receptor H3 )	0.73669
4	hsa185 ( angiotensin II receptor type 1 )	0.690482
5	hsa59340 ( histamine receptor H4 )	0.678874
6	hsa1131 ( cholinergic receptor muscarinic 3 )	0.669188
7	hsa1813 ( dopamine receptor D2 )	0.604258
8	hsa4988 ( opioid receptor mu 1 )	0.597304
9	hsa9052 ( G protein-coupled receptor class C group 5 member A )	0.583443
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.571262

D01745 : Domperidone (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01745 ( Domperidone )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa1814 ( dopamine receptor D3 )	0.929944	1	1	1
2	hsa1812 ( dopamine receptor D1 )	0.929407	0	0	0
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.88484	0	0	0
4	hsa3269 ( histamine receptor H1 )	0.848052	0	0	0
5	hsa1816 ( dopamine receptor D5 )	0.792522	0	0	0
6	hsa150 ( adrenoceptor alpha 2A )	0.779571	0	0	0
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.760754	0	0	0
8	hsa151 ( adrenoceptor alpha 2B )	0.756554	0	0	0
9	hsa148 ( adrenoceptor alpha 1A )	0.73905	0	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.691366	0	0	0

D01782 : Triprolidine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01782 ( Triprolidine hydrochloride )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.893879
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.844495
3	hsa1131 ( cholinergic receptor muscarinic 3 )	0.800663
4	hsa1813 ( dopamine receptor D2 )	0.798319
5	hsa1812 ( dopamine receptor D1 )	0.725797
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.703788
7	hsa59340 ( histamine receptor H4 )	0.697644
8	hsa11255 ( histamine receptor H3 )	0.681681
9	hsa1132 ( cholinergic receptor muscarinic 4 )	0.629857
10	hsa1133 ( cholinergic receptor muscarinic 5 )	0.616082

D01828 : Amlexanox (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01828 ( Amlexanox )

Rank	Target	Score
1	hsa57105 ( cysteinyl leukotriene receptor 2 )	0.896291
2	hsa5729 ( prostaglandin D2 receptor )	0.818801
3	hsa3269 ( histamine receptor H1 )	0.759538
4	hsa1241 ( leukotriene B4 receptor )	0.75819
5	hsa185 ( angiotensin II receptor type 1 )	0.734201
6	hsa56413 ( leukotriene B4 receptor 2 )	0.730748
7	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.723604
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.672523
9	hsa5724 ( platelet activating factor receptor )	0.651763
10	hsa64805 ( purinergic receptor P2Y12 )	0.633626

D01871 : Methixene hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01871 ( Methixene hydrochloride )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.949425
2	hsa1813 ( dopamine receptor D2 )	0.728955
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.680848
4	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.620657
5	hsa1815 ( dopamine receptor D4 )	0.604337
6	hsa148 ( adrenoceptor alpha 1A )	0.564975
7	hsa1812 ( dopamine receptor D1 )	0.562339
8	hsa4988 ( opioid receptor mu 1 )	0.554579
9	hsa11255 ( histamine receptor H3 )	0.55048
10	hsa154 ( adrenoceptor beta 2 )	0.533636

D01891 : Enprostil (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01891 ( Enprostil )

Rank	Target	Score	Validated	KEGG
1	hsa5731 ( prostaglandin E receptor 1 )	0.94291	0	0
2	hsa5732 ( prostaglandin E receptor 2 )	0.92573	1	1
3	hsa5737 ( prostaglandin F receptor )	0.911761	0	0
4	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.82126	0	0
5	hsa6915 ( thromboxane A2 receptor )	0.817362	0	0
6	hsa7201 ( thyrotropin releasing hormone receptor )	0.711085	0	0
7	hsa4988 ( opioid receptor mu 1 )	0.705228	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.674848	0	0
9	hsa153 ( adrenoceptor beta 1 )	0.669124	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.654995	0	0

D01925 : Taltirelin hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01925 ( Taltirelin hydrate )

Rank	Target	Score
1	hsa4988 ( opioid receptor mu 1 )	0.729189
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.726037
3	hsa185 ( angiotensin II receptor type 1 )	0.703575
4	hsa1813 ( dopamine receptor D2 )	0.652322
5	hsa150 ( adrenoceptor alpha 2A )	0.62692
6	hsa1128 ( cholinergic receptor muscarinic 1 )	0.62676
7	hsa5733 ( prostaglandin E receptor 3 )	0.61388
8	hsa4986 ( opioid receptor kappa 1 )	0.607337
9	hsa148 ( adrenoceptor alpha 1A )	0.601392
10	hsa154 ( adrenoceptor beta 2 )	0.59364

D01964 : Travoprost (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01964 ( Travoprost )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.925216
2	hsa5733 ( prostaglandin E receptor 3 )	0.912959
3	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.892354
4	hsa6915 ( thromboxane A2 receptor )	0.871793
5	hsa5732 ( prostaglandin E receptor 2 )	0.83524
6	hsa4988 ( opioid receptor mu 1 )	0.697365
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.645031
8	hsa64805 ( purinergic receptor P2Y12 )	0.628297
9	hsa154 ( adrenoceptor beta 2 )	0.627752
10	hsa185 ( angiotensin II receptor type 1 )	0.62599

D01965 : Silodosin (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01965 ( Silodosin )

Rank	Target	Score
1	hsa151 ( adrenoceptor alpha 2B )	0.862047
2	hsa150 ( adrenoceptor alpha 2A )	0.852539
3	hsa153 ( adrenoceptor beta 1 )	0.786752
4	hsa152 ( adrenoceptor alpha 2C )	0.767553
5	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.747887
6	hsa154 ( adrenoceptor beta 2 )	0.744915
7	hsa3269 ( histamine receptor H1 )	0.678652
8	hsa1813 ( dopamine receptor D2 )	0.667379
9	hsa155 ( adrenoceptor beta 3 )	0.64825
10	hsa3274 ( histamine receptor H2 )	0.631763

D01973 : Eletriptan hydrobromide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01973 ( Eletriptan hydrobromide )

Rank	Target	Score
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.950306
2	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.921592
3	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.908722
4	hsa1814 ( dopamine receptor D3 )	0.872708
5	hsa148 ( adrenoceptor alpha 1A )	0.869653
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.86753
7	hsa1813 ( dopamine receptor D2 )	0.829226
8	hsa147 ( adrenoceptor alpha 1B )	0.785285
9	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.770054
10	hsa150 ( adrenoceptor alpha 2A )	0.763837

D01994 : Mosapride citrate hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01994 ( Mosapride citrate hydrate )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.814877
2	hsa3269 ( histamine receptor H1 )	0.784215
3	hsa1812 ( dopamine receptor D1 )	0.742821
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.720065
5	hsa153 ( adrenoceptor beta 1 )	0.700037
6	hsa4988 ( opioid receptor mu 1 )	0.68941
7	hsa3274 ( histamine receptor H2 )	0.680064
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.676481
9	hsa148 ( adrenoceptor alpha 1A )	0.6615
10	hsa1129 ( cholinergic receptor muscarinic 2 )	0.659844

D02007 : Protirelin tartrate hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02007 ( Protirelin tartrate hydrate )

Rank	Target	Score
1	hsa4988 ( opioid receptor mu 1 )	0.751658
2	hsa185 ( angiotensin II receptor type 1 )	0.710328
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.696244
4	hsa5733 ( prostaglandin E receptor 3 )	0.644259
5	hsa150 ( adrenoceptor alpha 2A )	0.633742
6	hsa4986 ( opioid receptor kappa 1 )	0.633082
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.621684
8	hsa1813 ( dopamine receptor D2 )	0.617154
9	hsa5731 ( prostaglandin E receptor 1 )	0.597547
10	hsa154 ( adrenoceptor beta 2 )	0.577801

D02066 : Isoproterenol sulfate (Found 1 out of 16 validated targets)

Top-10 predicted interaction for: D02066 ( Isoproterenol sulfate )

Rank	Target	Score	Validated	Matador
1	hsa3274 ( histamine receptor H2 )	0.733455	0	0
2	hsa148 ( adrenoceptor alpha 1A )	0.718563	0	0
3	hsa146 ( adrenoceptor alpha 1D )	0.607263	0	0
4	hsa150 ( adrenoceptor alpha 2A )	0.58192	0	0
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.576388	0	0
6	hsa147 ( adrenoceptor alpha 1B )	0.568991	0	0
7	hsa151 ( adrenoceptor alpha 2B )	0.548089	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.545975	0	0
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.521167	1	1
10	hsa1812 ( dopamine receptor D1 )	0.518723	0	0

D02070 : Homatropine methylbromide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02070 ( Homatropine methylbromide )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.933389
2	hsa1813 ( dopamine receptor D2 )	0.667863
3	hsa4988 ( opioid receptor mu 1 )	0.646198
4	hsa154 ( adrenoceptor beta 2 )	0.573735
5	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.566791
6	hsa1815 ( dopamine receptor D4 )	0.562316
7	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.552719
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.546819
9	hsa11255 ( histamine receptor H3 )	0.544797
10	hsa1812 ( dopamine receptor D1 )	0.536043

D02076 : Brimonidine tartrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02076 ( Brimonidine tartrate )

Rank	Target	Score
1	hsa146 ( adrenoceptor alpha 1D )	0.858529
2	hsa148 ( adrenoceptor alpha 1A )	0.845023
3	hsa147 ( adrenoceptor alpha 1B )	0.833143
4	hsa1813 ( dopamine receptor D2 )	0.715217
5	hsa154 ( adrenoceptor beta 2 )	0.685475
6	hsa153 ( adrenoceptor beta 1 )	0.670931
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.637707
8	hsa185 ( angiotensin II receptor type 1 )	0.573856
9	hsa155 ( adrenoceptor beta 3 )	0.573055
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.549711

D02082 : Eprosartan mesylate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02082 ( Eprosartan mesylate )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.825985
2	hsa4988 ( opioid receptor mu 1 )	0.780893
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.689878
4	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.649725
5	hsa3269 ( histamine receptor H1 )	0.644197
6	hsa64805 ( purinergic receptor P2Y12 )	0.615767
7	hsa4986 ( opioid receptor kappa 1 )	0.604455
8	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.60167
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.600643
10	hsa148 ( adrenoceptor alpha 1A )	0.59473

D02147 : Albuterol (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D02147 ( Albuterol )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa153 ( adrenoceptor beta 1 )	0.9739	1	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.930916	1	0	1
3	hsa148 ( adrenoceptor alpha 1A )	0.732368	0	0	0
4	hsa3274 ( histamine receptor H2 )	0.700148	0	0	0
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.627626	0	0	0
6	hsa146 ( adrenoceptor alpha 1D )	0.618574	0	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.613235	0	0	0
8	hsa147 ( adrenoceptor alpha 1B )	0.585138	0	0	0
9	hsa151 ( adrenoceptor alpha 2B )	0.578855	0	0	0
10	hsa1812 ( dopamine receptor D1 )	0.57473	0	0	0

D02149 : Epinephrine bitartrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02149 ( Epinephrine bitartrate )

Rank	Target	Score
1	hsa3274 ( histamine receptor H2 )	0.630428
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.552656
3	hsa1813 ( dopamine receptor D2 )	0.544467
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.507274
5	hsa1812 ( dopamine receptor D1 )	0.477014
6	hsa185 ( angiotensin II receptor type 1 )	0.456921
7	hsa1816 ( dopamine receptor D5 )	0.426558
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.418545
9	hsa3269 ( histamine receptor H1 )	0.410696
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.400263

D02150 : l-Isoprenaline hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02150 ( l-Isoprenaline hydrochloride )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.787053
2	hsa3274 ( histamine receptor H2 )	0.704477
3	hsa146 ( adrenoceptor alpha 1D )	0.68202
4	hsa150 ( adrenoceptor alpha 2A )	0.650035
5	hsa147 ( adrenoceptor alpha 1B )	0.646142
6	hsa151 ( adrenoceptor alpha 2B )	0.620736
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.564131
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.530495
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.525187
10	hsa1812 ( dopamine receptor D1 )	0.52243

D02234 : Cyproheptadine hydrochloride (Found 2 out of 15 validated targets)

Top-10 predicted interaction for: D02234 ( Cyproheptadine hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa151 ( adrenoceptor alpha 2B )	0.857303	0	0	0	0
2	hsa150 ( adrenoceptor alpha 2A )	0.851097	0	0	0	0
3	hsa152 ( adrenoceptor alpha 2C )	0.777528	0	0	0	0
4	hsa153 ( adrenoceptor beta 1 )	0.746139	0	0	0	0
5	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.702946	1	0	1	1
6	hsa154 ( adrenoceptor beta 2 )	0.692551	0	0	0	0
7	hsa3274 ( histamine receptor H2 )	0.659172	0	0	0	0
8	hsa1813 ( dopamine receptor D2 )	0.655903	0	0	0	0
9	hsa185 ( angiotensin II receptor type 1 )	0.636089	0	0	0	0
10	hsa3269 ( histamine receptor H1 )	0.634503	1	1	1	1

D02237 : Guanethidine sulfate (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D02237 ( Guanethidine sulfate )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.729919
2	hsa154 ( adrenoceptor beta 2 )	0.69388
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.662365
4	hsa1813 ( dopamine receptor D2 )	0.63676
5	hsa155 ( adrenoceptor beta 3 )	0.625603
6	hsa3274 ( histamine receptor H2 )	0.570686
7	hsa185 ( angiotensin II receptor type 1 )	0.559187
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.557036
9	hsa3269 ( histamine receptor H1 )	0.524388
10	hsa3363 ( 5-hydroxytryptamine receptor 7 )	0.483484

D02250 : Octreotide acetate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02250 ( Octreotide acetate )

Rank	Target	Score	Validated	KEGG
1	hsa4988 ( opioid receptor mu 1 )	0.964655	0	0
2	hsa6751 ( somatostatin receptor 1 )	0.928768	1	1
3	hsa4986 ( opioid receptor kappa 1 )	0.894767	0	0
4	hsa4985 ( opioid receptor delta 1 )	0.814037	0	0
5	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.804112	0	0
6	hsa185 ( angiotensin II receptor type 1 )	0.793128	0	0
7	hsa886 ( cholecystokinin A receptor )	0.671527	0	0
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.66111	0	0
9	hsa154 ( adrenoceptor beta 2 )	0.65386	0	0
10	hsa6010 ( rhodopsin )	0.646739	0	0

D02278 : Lysine acetate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02278 ( Lysine acetate )

Rank	Target	Score
1	hsa2918 ( glutamate metabotropic receptor 8 )	0.759851
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.733715
3	hsa2913 ( glutamate metabotropic receptor 3 )	0.681301
4	hsa2916 ( glutamate metabotropic receptor 6 )	0.665279
5	hsa185 ( angiotensin II receptor type 1 )	0.6616
6	hsa2912 ( glutamate metabotropic receptor 2 )	0.66065
7	hsa3269 ( histamine receptor H1 )	0.65325
8	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.65311
9	hsa154 ( adrenoceptor beta 2 )	0.614498
10	hsa3274 ( histamine receptor H2 )	0.614076

D02279 : Lysine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02279 ( Lysine hydrochloride )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.740021
2	hsa2918 ( glutamate metabotropic receptor 8 )	0.704838
3	hsa185 ( angiotensin II receptor type 1 )	0.676522
4	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.640382
5	hsa3269 ( histamine receptor H1 )	0.625745
6	hsa2913 ( glutamate metabotropic receptor 3 )	0.624009
7	hsa154 ( adrenoceptor beta 2 )	0.622578
8	hsa3274 ( histamine receptor H2 )	0.619984
9	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.615264
10	hsa148 ( adrenoceptor alpha 1A )	0.610231

D02327 : Doxylamine succinate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02327 ( Doxylamine succinate )

Rank	Target	Score
1	hsa1129 ( cholinergic receptor muscarinic 2 )	0.943366
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.906654
3	hsa1132 ( cholinergic receptor muscarinic 4 )	0.802559
4	hsa1133 ( cholinergic receptor muscarinic 5 )	0.767945
5	hsa11255 ( histamine receptor H3 )	0.704589
6	hsa59340 ( histamine receptor H4 )	0.687347
7	hsa1813 ( dopamine receptor D2 )	0.669135
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.613804
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.600401
10	hsa148 ( adrenoceptor alpha 1A )	0.580363

D02338 : Acebutolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02338 ( Acebutolol )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.759286
2	hsa3274 ( histamine receptor H2 )	0.713179
3	hsa146 ( adrenoceptor alpha 1D )	0.645789
4	hsa147 ( adrenoceptor alpha 1B )	0.610827
5	hsa150 ( adrenoceptor alpha 2A )	0.605964
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.605656
7	hsa151 ( adrenoceptor alpha 2B )	0.569769
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.55871
9	hsa1812 ( dopamine receptor D1 )	0.525595
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.515049

D02340 : Loxapine (Found 9 out of 25 validated targets)

Top-10 predicted interaction for: D02340 ( Loxapine )

Rank	Target	Score	Validated	DrugBank
1	hsa1812 ( dopamine receptor D1 )	0.945771	1	1
2	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.908768	1	1
3	hsa3269 ( histamine receptor H1 )	0.874123	1	1
4	hsa148 ( adrenoceptor alpha 1A )	0.826255	1	1
5	hsa1816 ( dopamine receptor D5 )	0.819387	1	1
6	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.803653	1	1
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.80078	1	1
8	hsa150 ( adrenoceptor alpha 2A )	0.796434	1	1
9	hsa151 ( adrenoceptor alpha 2B )	0.791049	1	1
10	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.78269	0	0

D02342 : Bisoprolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02342 ( Bisoprolol )

Rank	Target	Score
1	hsa155 ( adrenoceptor beta 3 )	0.932887
2	hsa148 ( adrenoceptor alpha 1A )	0.727257
3	hsa3274 ( histamine receptor H2 )	0.685232
4	hsa146 ( adrenoceptor alpha 1D )	0.611584
5	hsa150 ( adrenoceptor alpha 2A )	0.599203
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.58224
7	hsa147 ( adrenoceptor alpha 1B )	0.57874
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.574863
9	hsa151 ( adrenoceptor alpha 2B )	0.564931
10	hsa1812 ( dopamine receptor D1 )	0.525948

D02349 : Dipivefrin (Found 8 out of 8 validated targets)

Top-10 predicted interaction for: D02349 ( Dipivefrin )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa151 ( adrenoceptor alpha 2B )	0.951897	1	1	0
2	hsa152 ( adrenoceptor alpha 2C )	0.944364	1	1	0
3	hsa146 ( adrenoceptor alpha 1D )	0.828089	1	1	0
4	hsa148 ( adrenoceptor alpha 1A )	0.824983	1	1	1
5	hsa154 ( adrenoceptor beta 2 )	0.812127	1	1	1
6	hsa153 ( adrenoceptor beta 1 )	0.798282	1	1	0
7	hsa147 ( adrenoceptor alpha 1B )	0.795461	1	1	0
8	hsa155 ( adrenoceptor beta 3 )	0.719371	1	1	0
9	hsa1813 ( dopamine receptor D2 )	0.68766	0	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.612812	0	0	0

D02354 : Thiethylperazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02354 ( Thiethylperazine )

Rank	Target	Score
1	hsa1814 ( dopamine receptor D3 )	0.872273
2	hsa1816 ( dopamine receptor D5 )	0.699385
3	hsa148 ( adrenoceptor alpha 1A )	0.648341
4	hsa151 ( adrenoceptor alpha 2B )	0.635942
5	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.592561
6	hsa150 ( adrenoceptor alpha 2A )	0.582986
7	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.538225
8	hsa146 ( adrenoceptor alpha 1D )	0.534262
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.533774
10	hsa147 ( adrenoceptor alpha 1B )	0.516742

D02356 : Verapamil (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D02356 ( Verapamil )

Rank	Target	Score
1	hsa152 ( adrenoceptor alpha 2C )	0.878624
2	hsa1131 ( cholinergic receptor muscarinic 3 )	0.819186
3	hsa3269 ( histamine receptor H1 )	0.790189
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.711195
5	hsa153 ( adrenoceptor beta 1 )	0.680684
6	hsa154 ( adrenoceptor beta 2 )	0.660408
7	hsa1813 ( dopamine receptor D2 )	0.658133
8	hsa1133 ( cholinergic receptor muscarinic 5 )	0.649439
9	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.631314
10	hsa155 ( adrenoceptor beta 3 )	0.582436

D02357 : Methysergide (Found 3 out of 8 validated targets)

Top-10 predicted interaction for: D02357 ( Methysergide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1813 ( dopamine receptor D2 )	0.933243	0	0	0
2	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.919894	1	1	1
3	hsa1814 ( dopamine receptor D3 )	0.878487	0	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.855746	0	0	0
5	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.837427	1	1	1
6	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.806587	1	0	1
7	hsa1812 ( dopamine receptor D1 )	0.801774	0	0	0
8	hsa146 ( adrenoceptor alpha 1D )	0.797784	0	0	0
9	hsa3269 ( histamine receptor H1 )	0.789101	0	0	0
10	hsa147 ( adrenoceptor alpha 1B )	0.785911	0	0	0

D02358 : Metoprolol (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02358 ( Metoprolol )

Rank	Target	Score	Validated	DrugBank
1	hsa154 ( adrenoceptor beta 2 )	0.981689	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.937916	0	0
3	hsa148 ( adrenoceptor alpha 1A )	0.750818	0	0
4	hsa3274 ( histamine receptor H2 )	0.718107	0	0
5	hsa146 ( adrenoceptor alpha 1D )	0.627075	0	0
6	hsa147 ( adrenoceptor alpha 1B )	0.598757	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.581798	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.575053	0	0
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.559276	0	0
10	hsa151 ( adrenoceptor alpha 2B )	0.549758	0	0

D02359 : Ritodrine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02359 ( Ritodrine )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.970261
2	hsa155 ( adrenoceptor beta 3 )	0.920885
3	hsa3274 ( histamine receptor H2 )	0.685747
4	hsa148 ( adrenoceptor alpha 1A )	0.662619
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.620361
6	hsa150 ( adrenoceptor alpha 2A )	0.57304
7	hsa1812 ( dopamine receptor D1 )	0.572505
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.560738
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.55635
10	hsa146 ( adrenoceptor alpha 1D )	0.538105

D02361 : Propiomazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02361 ( Propiomazine )

Rank	Target	Score
1	hsa151 ( adrenoceptor alpha 2B )	0.773361
2	hsa1814 ( dopamine receptor D3 )	0.731869
3	hsa150 ( adrenoceptor alpha 2A )	0.689428
4	hsa154 ( adrenoceptor beta 2 )	0.613825
5	hsa153 ( adrenoceptor beta 1 )	0.601956
6	hsa1816 ( dopamine receptor D5 )	0.56621
7	hsa59340 ( histamine receptor H4 )	0.546844
8	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.513102
9	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.481044
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.4674

D02374 : Metipranolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02374 ( Metipranolol )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.763458
2	hsa3274 ( histamine receptor H2 )	0.69745
3	hsa146 ( adrenoceptor alpha 1D )	0.65426
4	hsa150 ( adrenoceptor alpha 2A )	0.634192
5	hsa147 ( adrenoceptor alpha 1B )	0.6176
6	hsa151 ( adrenoceptor alpha 2B )	0.591046
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.568265
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.565501
9	hsa136 ( adenosine A2b receptor )	0.506974
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.503372

D02566 : Maprotiline (Found 8 out of 14 validated targets)

Top-10 predicted interaction for: D02566 ( Maprotiline )

Rank	Target	Score	Validated	DrugBank
1	hsa147 ( adrenoceptor alpha 1B )	0.813609	1	1
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.801997	1	1
3	hsa146 ( adrenoceptor alpha 1D )	0.796095	1	1
4	hsa3274 ( histamine receptor H2 )	0.735389	0	0
5	hsa1813 ( dopamine receptor D2 )	0.712478	1	1
6	hsa1129 ( cholinergic receptor muscarinic 2 )	0.686396	1	1
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.671586	1	1
8	hsa151 ( adrenoceptor alpha 2B )	0.630444	1	1
9	hsa1131 ( cholinergic receptor muscarinic 3 )	0.627028	1	1
10	hsa1812 ( dopamine receptor D1 )	0.62194	0	0

D02578 : Agomelatine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02578 ( Agomelatine )

Rank	Target	Score
1	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.896157
2	hsa154 ( adrenoceptor beta 2 )	0.725553
3	hsa1814 ( dopamine receptor D3 )	0.722956
4	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.722232
5	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.717489
6	hsa1813 ( dopamine receptor D2 )	0.715737
7	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.712875
8	hsa150 ( adrenoceptor alpha 2A )	0.700599
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.676995
10	hsa153 ( adrenoceptor beta 1 )	0.665766

D02588 : Montirelin (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02588 ( Montirelin )

Rank	Target	Score
1	hsa4988 ( opioid receptor mu 1 )	0.750702
2	hsa185 ( angiotensin II receptor type 1 )	0.701356
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.679949
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.674602
5	hsa4986 ( opioid receptor kappa 1 )	0.625657
6	hsa5733 ( prostaglandin E receptor 3 )	0.613691
7	hsa1813 ( dopamine receptor D2 )	0.610607
8	hsa1129 ( cholinergic receptor muscarinic 2 )	0.603571
9	hsa3269 ( histamine receptor H1 )	0.602773
10	hsa150 ( adrenoceptor alpha 2A )	0.587358

D02614 : Denopamine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02614 ( Denopamine )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.982608
2	hsa155 ( adrenoceptor beta 3 )	0.939121
3	hsa3274 ( histamine receptor H2 )	0.72076
4	hsa148 ( adrenoceptor alpha 1A )	0.716875
5	hsa146 ( adrenoceptor alpha 1D )	0.584754
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.57147
7	hsa150 ( adrenoceptor alpha 2A )	0.571423
8	hsa1812 ( dopamine receptor D1 )	0.560997
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.552192
10	hsa147 ( adrenoceptor alpha 1B )	0.549851

D02671 : Mesoridazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02671 ( Mesoridazine )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.918246
2	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.796978
3	hsa1128 ( cholinergic receptor muscarinic 1 )	0.761456
4	hsa151 ( adrenoceptor alpha 2B )	0.72957
5	hsa150 ( adrenoceptor alpha 2A )	0.722497
6	hsa148 ( adrenoceptor alpha 1A )	0.718824
7	hsa1815 ( dopamine receptor D4 )	0.695621
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.684245
9	hsa1129 ( cholinergic receptor muscarinic 2 )	0.651497
10	hsa154 ( adrenoceptor beta 2 )	0.64123

D02721 : Iloprost (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02721 ( Iloprost )

Rank	Target	Score
1	hsa5737 ( prostaglandin F receptor )	0.931409
2	hsa5732 ( prostaglandin E receptor 2 )	0.920371
3	hsa5733 ( prostaglandin E receptor 3 )	0.900744
4	hsa6915 ( thromboxane A2 receptor )	0.8107
5	hsa4988 ( opioid receptor mu 1 )	0.725057
6	hsa64805 ( purinergic receptor P2Y12 )	0.701652
7	hsa154 ( adrenoceptor beta 2 )	0.660557
8	hsa153 ( adrenoceptor beta 1 )	0.657774
9	hsa5729 ( prostaglandin D2 receptor )	0.622092
10	hsa3269 ( histamine receptor H1 )	0.61195

D02725 : Sulprostone (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02725 ( Sulprostone )

Rank	Target	Score	Validated	KEGG
1	hsa5732 ( prostaglandin E receptor 2 )	0.936971	1	1
2	hsa5737 ( prostaglandin F receptor )	0.926372	0	0
3	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.893277	0	0
4	hsa6915 ( thromboxane A2 receptor )	0.841594	0	0
5	hsa4988 ( opioid receptor mu 1 )	0.731669	0	0
6	hsa7201 ( thyrotropin releasing hormone receptor )	0.684749	0	0
7	hsa153 ( adrenoceptor beta 1 )	0.637511	0	0
8	hsa154 ( adrenoceptor beta 2 )	0.63015	0	0
9	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.601986	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.59977	0	0

D02826 : Alniditan dihydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02826 ( Alniditan dihydrochloride )

Rank	Target	Score
1	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.94809
2	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.885639
3	hsa148 ( adrenoceptor alpha 1A )	0.854684
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.845101
5	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.839472
6	hsa1814 ( dopamine receptor D3 )	0.83433
7	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.819549
8	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.811234
9	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.800624
10	hsa150 ( adrenoceptor alpha 2A )	0.799518

D02884 : Ambuphylline (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02884 ( Ambuphylline )

Rank	Target	Score
1	hsa136 ( adenosine A2b receptor )	0.959827
2	hsa140 ( adenosine A3 receptor )	0.939955
3	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.832699
4	hsa185 ( angiotensin II receptor type 1 )	0.769503
5	hsa64805 ( purinergic receptor P2Y12 )	0.751477
6	hsa150 ( adrenoceptor alpha 2A )	0.675221
7	hsa154 ( adrenoceptor beta 2 )	0.639887
8	hsa5029 ( purinergic receptor P2Y2 )	0.628208
9	hsa10161 ( lysophosphatidic acid receptor 6 )	0.608439
10	hsa5731 ( prostaglandin E receptor 1 )	0.606928

D02910 : Amiodarone (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D02910 ( Amiodarone )

Rank	Target	Score	Validated	KEGG
1	hsa154 ( adrenoceptor beta 2 )	0.94206	0	0
2	hsa147 ( adrenoceptor alpha 1B )	0.912605	1	1
3	hsa146 ( adrenoceptor alpha 1D )	0.9125	1	1
4	hsa155 ( adrenoceptor beta 3 )	0.881678	0	0
5	hsa3274 ( histamine receptor H2 )	0.732313	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.715043	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.699338	0	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.619956	0	0
9	hsa1813 ( dopamine receptor D2 )	0.590885	0	0
10	hsa3269 ( histamine receptor H1 )	0.589997	0	0

D03165 : Bromocriptine (Found 8 out of 17 validated targets)

Top-10 predicted interaction for: D03165 ( Bromocriptine )

Rank	Target	Score	Validated	DrugBank
1	hsa1814 ( dopamine receptor D3 )	0.925562	1	1
2	hsa1812 ( dopamine receptor D1 )	0.911101	1	1
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.867659	1	1
4	hsa150 ( adrenoceptor alpha 2A )	0.793849	1	1
5	hsa3269 ( histamine receptor H1 )	0.767265	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.760281	1	1
7	hsa1816 ( dopamine receptor D5 )	0.757166	1	1
8	hsa148 ( adrenoceptor alpha 1A )	0.737631	1	1
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.672281	0	0
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.648392	1	1

D03187 : Butaprost (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03187 ( Butaprost )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.950326
2	hsa5733 ( prostaglandin E receptor 3 )	0.950291
3	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.927026
4	hsa5737 ( prostaglandin F receptor )	0.900622
5	hsa6915 ( thromboxane A2 receptor )	0.792534
6	hsa4988 ( opioid receptor mu 1 )	0.693355
7	hsa154 ( adrenoceptor beta 2 )	0.671155
8	hsa153 ( adrenoceptor beta 1 )	0.666206
9	hsa5729 ( prostaglandin D2 receptor )	0.65579
10	hsa185 ( angiotensin II receptor type 1 )	0.636771

D03210 : Ancriviroc (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03210 ( Ancriviroc )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.875741
2	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.851047
3	hsa3269 ( histamine receptor H1 )	0.741269
4	hsa4988 ( opioid receptor mu 1 )	0.692334
5	hsa1128 ( cholinergic receptor muscarinic 1 )	0.689399
6	hsa148 ( adrenoceptor alpha 1A )	0.683348
7	hsa1129 ( cholinergic receptor muscarinic 2 )	0.655914
8	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.606184
9	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.605481
10	hsa147 ( adrenoceptor alpha 1B )	0.596515

D03274 : Chlorpromazine hibenzate (Found 7 out of 21 validated targets)

Top-10 predicted interaction for: D03274 ( Chlorpromazine hibenzate )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa146 ( adrenoceptor alpha 1D )	0.818984	1	0	1	0
2	hsa148 ( adrenoceptor alpha 1A )	0.801961	1	0	1	0
3	hsa147 ( adrenoceptor alpha 1B )	0.784648	1	0	1	0
4	hsa1813 ( dopamine receptor D2 )	0.767854	1	1	1	1
5	hsa154 ( adrenoceptor beta 2 )	0.672819	0	0	0	0
6	hsa153 ( adrenoceptor beta 1 )	0.647123	0	0	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.630337	0	0	0	0
8	hsa1814 ( dopamine receptor D3 )	0.611737	1	0	1	1
9	hsa1812 ( dopamine receptor D1 )	0.610997	1	0	1	1
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.587254	1	1	1	0

D03365 : Nicotine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03365 ( Nicotine )

Rank	Target	Score
1	hsa338442 ( hydroxycarboxylic acid receptor 2 )	0.845737
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.773361
3	hsa1129 ( cholinergic receptor muscarinic 2 )	0.735444
4	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.728647
5	hsa3269 ( histamine receptor H1 )	0.723563
6	hsa185 ( angiotensin II receptor type 1 )	0.723077
7	hsa4988 ( opioid receptor mu 1 )	0.702348
8	hsa1813 ( dopamine receptor D2 )	0.637047
9	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.596849
10	hsa9283 ( G protein-coupled receptor 37 like 1 )	0.562615

D03415 : Carvedilol phosphate (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D03415 ( Carvedilol phosphate )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa148 ( adrenoceptor alpha 1A )	0.763192	1	1	1	1
2	hsa3274 ( histamine receptor H2 )	0.696853	0	0	0	0
3	hsa150 ( adrenoceptor alpha 2A )	0.689605	1	0	1	1
4	hsa146 ( adrenoceptor alpha 1D )	0.666013	1	1	1	1
5	hsa151 ( adrenoceptor alpha 2B )	0.652312	1	0	1	1
6	hsa147 ( adrenoceptor alpha 1B )	0.628422	1	1	1	1
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.568281	0	0	0	0
8	hsa152 ( adrenoceptor alpha 2C )	0.554412	1	0	1	0
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.545372	0	0	0	0
10	hsa1128 ( cholinergic receptor muscarinic 1 )	0.504304	0	0	0	0

D03442 : Ceruletide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03442 ( Ceruletide )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.836399
2	hsa153 ( adrenoceptor beta 1 )	0.790497
3	hsa7201 ( thyrotropin releasing hormone receptor )	0.689425
4	hsa155 ( adrenoceptor beta 3 )	0.65795
5	hsa3269 ( histamine receptor H1 )	0.652152
6	hsa5737 ( prostaglandin F receptor )	0.634964
7	hsa6752 ( somatostatin receptor 2 )	0.622034
8	hsa4988 ( opioid receptor mu 1 )	0.619553
9	hsa9052 ( G protein-coupled receptor class C group 5 member A )	0.614958
10	hsa6010 ( rhodopsin )	0.614377

D03490 : Cicloprolol hydrochloride (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D03490 ( Cicloprolol hydrochloride )

Rank	Target	Score	Validated	KEGG
1	hsa155 ( adrenoceptor beta 3 )	0.934922	1	1
2	hsa3274 ( histamine receptor H2 )	0.710338	0	0
3	hsa148 ( adrenoceptor alpha 1A )	0.709861	0	0
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.58727	0	0
5	hsa146 ( adrenoceptor alpha 1D )	0.574989	0	0
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.564547	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.55538	0	0
8	hsa147 ( adrenoceptor alpha 1B )	0.544799	0	0
9	hsa1812 ( dopamine receptor D1 )	0.531148	0	0
10	hsa151 ( adrenoceptor alpha 2B )	0.521661	0	0

D03503 : Cimetidine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03503 ( Cimetidine hydrochloride )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.86785
2	hsa153 ( adrenoceptor beta 1 )	0.846216
3	hsa148 ( adrenoceptor alpha 1A )	0.749064
4	hsa155 ( adrenoceptor beta 3 )	0.716895
5	hsa3269 ( histamine receptor H1 )	0.692546
6	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.681507
7	hsa59340 ( histamine receptor H4 )	0.660538
8	hsa136 ( adenosine A2b receptor )	0.646813
9	hsa147 ( adrenoceptor alpha 1B )	0.620211
10	hsa146 ( adrenoceptor alpha 1D )	0.612508

D03621 : Cyclizine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03621 ( Cyclizine )

Rank	Target	Score
1	hsa1132 ( cholinergic receptor muscarinic 4 )	0.86605
2	hsa1133 ( cholinergic receptor muscarinic 5 )	0.834027
3	hsa1813 ( dopamine receptor D2 )	0.731659
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.700796
5	hsa148 ( adrenoceptor alpha 1A )	0.650022
6	hsa11255 ( histamine receptor H3 )	0.621052
7	hsa59340 ( histamine receptor H4 )	0.602347
8	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.598705
9	hsa1812 ( dopamine receptor D1 )	0.590573
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.571216

D03642 : Daltroban (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03642 ( Daltroban )

Rank	Target	Score
1	hsa5737 ( prostaglandin F receptor )	0.822663
2	hsa5731 ( prostaglandin E receptor 1 )	0.793423
3	hsa5733 ( prostaglandin E receptor 3 )	0.772712
4	hsa154 ( adrenoceptor beta 2 )	0.708607
5	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.69918
6	hsa5732 ( prostaglandin E receptor 2 )	0.67335
7	hsa4988 ( opioid receptor mu 1 )	0.66804
8	hsa1813 ( dopamine receptor D2 )	0.666145
9	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.649275
10	hsa153 ( adrenoceptor beta 1 )	0.646758

D03654 : Darifenacin (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D03654 ( Darifenacin )

Rank	Target	Score	Validated	DrugBank
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.975593	1	1
2	hsa1129 ( cholinergic receptor muscarinic 2 )	0.965872	1	1
3	hsa3269 ( histamine receptor H1 )	0.905022	0	0
4	hsa1132 ( cholinergic receptor muscarinic 4 )	0.878812	1	1
5	hsa1133 ( cholinergic receptor muscarinic 5 )	0.845776	1	1
6	hsa1813 ( dopamine receptor D2 )	0.670198	0	0
7	hsa148 ( adrenoceptor alpha 1A )	0.635138	0	0
8	hsa4988 ( opioid receptor mu 1 )	0.620033	0	0
9	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.614274	0	0
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.606449	0	0

D03858 : Diphenidol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03858 ( Diphenidol )

Rank	Target	Score
1	hsa3269 ( histamine receptor H1 )	0.937523
2	hsa1132 ( cholinergic receptor muscarinic 4 )	0.879692
3	hsa1133 ( cholinergic receptor muscarinic 5 )	0.842781
4	hsa1813 ( dopamine receptor D2 )	0.703548
5	hsa148 ( adrenoceptor alpha 1A )	0.646165
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.625439
7	hsa147 ( adrenoceptor alpha 1B )	0.559755
8	hsa146 ( adrenoceptor alpha 1D )	0.55474
9	hsa154 ( adrenoceptor beta 2 )	0.554481
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.551734

D03879 : Dobutamine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03879 ( Dobutamine )

Rank	Target	Score
1	hsa148 ( adrenoceptor alpha 1A )	0.742638
2	hsa3274 ( histamine receptor H2 )	0.694476
3	hsa146 ( adrenoceptor alpha 1D )	0.62771
4	hsa150 ( adrenoceptor alpha 2A )	0.606424
5	hsa147 ( adrenoceptor alpha 1B )	0.588919
6	hsa151 ( adrenoceptor alpha 2B )	0.578542
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.562734
8	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.561716
9	hsa1128 ( cholinergic receptor muscarinic 1 )	0.543221
10	hsa1812 ( dopamine receptor D1 )	0.532808

D03880 : Dobutamine lactobionate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D03880 ( Dobutamine lactobionate )

Rank	Target	Score	Validated	Matador
1	hsa155 ( adrenoceptor beta 3 )	0.929561	1	1
2	hsa148 ( adrenoceptor alpha 1A )	0.733692	0	0
3	hsa3274 ( histamine receptor H2 )	0.714651	0	0
4	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.612258	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.609954	0	0
6	hsa146 ( adrenoceptor alpha 1D )	0.609026	0	0
7	hsa147 ( adrenoceptor alpha 1B )	0.575846	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.574625	0	0
9	hsa151 ( adrenoceptor alpha 2B )	0.573431	0	0
10	hsa1812 ( dopamine receptor D1 )	0.54843	0	0

D03881 : Dobutamine tartrate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D03881 ( Dobutamine tartrate )

Rank	Target	Score	Validated	Matador
1	hsa155 ( adrenoceptor beta 3 )	0.933283	1	1
2	hsa148 ( adrenoceptor alpha 1A )	0.741157	0	0
3	hsa3274 ( histamine receptor H2 )	0.681865	0	0
4	hsa146 ( adrenoceptor alpha 1D )	0.627274	0	0
5	hsa150 ( adrenoceptor alpha 2A )	0.625571	0	0
6	hsa151 ( adrenoceptor alpha 2B )	0.594452	0	0
7	hsa147 ( adrenoceptor alpha 1B )	0.592551	0	0
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.583993	0	0
9	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.554659	0	0
10	hsa1812 ( dopamine receptor D1 )	0.536772	0	0

D03966 : Eglumetad (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03966 ( Eglumetad )

Rank	Target	Score
1	hsa2914 ( glutamate metabotropic receptor 4 )	0.906407
2	hsa2917 ( glutamate metabotropic receptor 7 )	0.901873
3	hsa222545 ( G protein-coupled receptor class C group 6 member A )	0.869369
4	hsa2911 ( glutamate metabotropic receptor 1 )	0.837476
5	hsa2915 ( glutamate metabotropic receptor 5 )	0.825026
6	hsa3269 ( histamine receptor H1 )	0.811971
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.725643
8	hsa1129 ( cholinergic receptor muscarinic 2 )	0.669027
9	hsa2550 ( gamma-aminobutyric acid type B receptor subunit 1 )	0.658964
10	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.623787

D04006 : Enprofylline (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D04006 ( Enprofylline )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa135 ( adenosine A2a receptor )	0.931734	1	1	1
2	hsa134 ( adenosine A1 receptor )	0.930552	1	1	1
3	hsa140 ( adenosine A3 receptor )	0.858908	1	0	1
4	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.81658	0	0	0
5	hsa185 ( angiotensin II receptor type 1 )	0.797035	0	0	0
6	hsa64805 ( purinergic receptor P2Y12 )	0.749921	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.70131	0	0	0
8	hsa153 ( adrenoceptor beta 1 )	0.674738	0	0	0
9	hsa3274 ( histamine receptor H2 )	0.653523	0	0	0
10	hsa1268 ( cannabinoid receptor 1 )	0.643644	0	0	0

D04034 : Chlorpromazine phenolphthalinate (Found 6 out of 21 validated targets)

Top-10 predicted interaction for: D04034 ( Chlorpromazine phenolphthalinate )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa146 ( adrenoceptor alpha 1D )	0.860738	1	0	1	0
2	hsa148 ( adrenoceptor alpha 1A )	0.850697	1	0	1	0
3	hsa147 ( adrenoceptor alpha 1B )	0.834603	1	0	1	0
4	hsa1813 ( dopamine receptor D2 )	0.749953	1	1	1	1
5	hsa154 ( adrenoceptor beta 2 )	0.691571	0	0	0	0
6	hsa153 ( adrenoceptor beta 1 )	0.674734	0	0	0	0
7	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.613874	0	0	0	0
8	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.594695	1	1	1	0
9	hsa1812 ( dopamine receptor D1 )	0.585565	1	0	1	1
10	hsa155 ( adrenoceptor beta 3 )	0.574693	0	0	0	0

D04040 : Eprosartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D04040 ( Eprosartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.83848
2	hsa4988 ( opioid receptor mu 1 )	0.803632
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.682725
4	hsa3269 ( histamine receptor H1 )	0.642584
5	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.641418
6	hsa4986 ( opioid receptor kappa 1 )	0.622777
7	hsa148 ( adrenoceptor alpha 1A )	0.614948
8	hsa1128 ( cholinergic receptor muscarinic 1 )	0.610781
9	hsa64805 ( purinergic receptor P2Y12 )	0.604229
10	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.583885

D04375 : Guanabenz (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D04375 ( Guanabenz )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa151 ( adrenoceptor alpha 2B )	0.964606	1	1	1
2	hsa152 ( adrenoceptor alpha 2C )	0.961343	1	1	0
3	hsa146 ( adrenoceptor alpha 1D )	0.864905	0	0	0
4	hsa148 ( adrenoceptor alpha 1A )	0.854216	0	0	0
5	hsa147 ( adrenoceptor alpha 1B )	0.841165	0	0	0
6	hsa1813 ( dopamine receptor D2 )	0.711185	0	0	0
7	hsa154 ( adrenoceptor beta 2 )	0.673295	0	0	0
8	hsa153 ( adrenoceptor beta 1 )	0.666995	0	0	0
9	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.632719	0	0	0
10	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.622138	0	0	0

D04625 : Isoetharine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D04625 ( Isoetharine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa154 ( adrenoceptor beta 2 )	0.980864	1	1	1
2	hsa155 ( adrenoceptor beta 3 )	0.941091	0	0	0
3	hsa148 ( adrenoceptor alpha 1A )	0.791035	0	0	0
4	hsa3274 ( histamine receptor H2 )	0.71549	0	0	0
5	hsa146 ( adrenoceptor alpha 1D )	0.677451	0	0	0
6	hsa147 ( adrenoceptor alpha 1B )	0.646003	0	0	0
7	hsa150 ( adrenoceptor alpha 2A )	0.639622	0	0	0
8	hsa151 ( adrenoceptor alpha 2B )	0.607661	0	0	0
9	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.586482	0	0	0
10	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.518974	0	0	0

D04716 : Levomethadyl acetate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D04716 ( Levomethadyl acetate )

Rank	Target	Score
1	hsa4986 ( opioid receptor kappa 1 )	0.910516
2	hsa4985 ( opioid receptor delta 1 )	0.815584
3	hsa1128 ( cholinergic receptor muscarinic 1 )	0.791719
4	hsa185 ( angiotensin II receptor type 1 )	0.770424
5	hsa3269 ( histamine receptor H1 )	0.751819
6	hsa1129 ( cholinergic receptor muscarinic 2 )	0.740782
7	hsa6752 ( somatostatin receptor 2 )	0.693424
8	hsa1131 ( cholinergic receptor muscarinic 3 )	0.685914
9	hsa6755 ( somatostatin receptor 5 )	0.641795
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.641789

D04979 : Methdilazine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D04979 ( Methdilazine )

Rank	Target	Score
1	hsa1128 ( cholinergic receptor muscarinic 1 )	0.85285
2	hsa1813 ( dopamine receptor D2 )	0.790813
3	hsa1129 ( cholinergic receptor muscarinic 2 )	0.787147
4	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.765895
5	hsa1131 ( cholinergic receptor muscarinic 3 )	0.72095
6	hsa148 ( adrenoceptor alpha 1A )	0.71755
7	hsa59340 ( histamine receptor H4 )	0.709887
8	hsa1812 ( dopamine receptor D1 )	0.707359
9	hsa11255 ( histamine receptor H3 )	0.671436
10	hsa147 ( adrenoceptor alpha 1B )	0.594776

D05113 : Naltrexone (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D05113 ( Naltrexone )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa4986 ( opioid receptor kappa 1 )	0.945851	1	1	1
2	hsa4985 ( opioid receptor delta 1 )	0.882308	1	1	1
3	hsa185 ( angiotensin II receptor type 1 )	0.80546	0	0	0
4	hsa7201 ( thyrotropin releasing hormone receptor )	0.723918	0	0	0
5	hsa6752 ( somatostatin receptor 2 )	0.696098	0	0	0
6	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.683649	0	0	0
7	hsa1128 ( cholinergic receptor muscarinic 1 )	0.664816	0	0	0
8	hsa6755 ( somatostatin receptor 5 )	0.663633	0	0	0
9	hsa1812 ( dopamine receptor D1 )	0.653706	0	0	0
10	hsa1813 ( dopamine receptor D2 )	0.648841	0	0	0

D05129 : Nedocromil (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05129 ( Nedocromil )

Rank	Target	Score
1	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.762685
2	hsa1128 ( cholinergic receptor muscarinic 1 )	0.757435
3	hsa56413 ( leukotriene B4 receptor 2 )	0.731982
4	hsa1241 ( leukotriene B4 receptor )	0.729209
5	hsa1129 ( cholinergic receptor muscarinic 2 )	0.700338
6	hsa185 ( angiotensin II receptor type 1 )	0.67452
7	hsa64805 ( purinergic receptor P2Y12 )	0.647987
8	hsa1813 ( dopamine receptor D2 )	0.623315
9	hsa1131 ( cholinergic receptor muscarinic 3 )	0.616858
10	hsa5724 ( platelet activating factor receptor )	0.611332

D05246 : Olmesartan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05246 ( Olmesartan )

Rank	Target	Score
1	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.842998
2	hsa4988 ( opioid receptor mu 1 )	0.807235
3	hsa1234 ( C-C motif chemokine receptor 5 (gene/pseudogene) )	0.695339
4	hsa8843 ( hydroxycarboxylic acid receptor 3 )	0.643097
5	hsa4986 ( opioid receptor kappa 1 )	0.638405
6	hsa148 ( adrenoceptor alpha 1A )	0.626098
7	hsa64805 ( purinergic receptor P2Y12 )	0.604627
8	hsa136 ( adenosine A2b receptor )	0.598858
9	hsa7201 ( thyrotropin releasing hormone receptor )	0.585387
10	hsa10800 ( cysteinyl leukotriene receptor 1 )	0.581703

D05312 : Oxycodone (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05312 ( Oxycodone )

Rank	Target	Score
1	hsa185 ( angiotensin II receptor type 1 )	0.824409
2	hsa1812 ( dopamine receptor D1 )	0.807243
3	hsa7201 ( thyrotropin releasing hormone receptor )	0.804918
4	hsa1814 ( dopamine receptor D3 )	0.766542
5	hsa1813 ( dopamine receptor D2 )	0.745837
6	hsa6752 ( somatostatin receptor 2 )	0.725042
7	hsa6755 ( somatostatin receptor 5 )	0.720721
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.68895
9	hsa6753 ( somatostatin receptor 3 )	0.675446
10	hsa4543 ( melatonin receptor 1A )	0.653687

D05341 : Palmitic acid (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05341 ( Palmitic acid )

Rank	Target	Score
1	hsa5731 ( prostaglandin E receptor 1 )	0.782229
2	hsa5739 ( prostaglandin I2 (prostacyclin) receptor (IP) )	0.761265
3	hsa5732 ( prostaglandin E receptor 2 )	0.736276
4	hsa4988 ( opioid receptor mu 1 )	0.734574
5	hsa5733 ( prostaglandin E receptor 3 )	0.705143
6	hsa154 ( adrenoceptor beta 2 )	0.702351
7	hsa5737 ( prostaglandin F receptor )	0.695542
8	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.693113
9	hsa153 ( adrenoceptor beta 1 )	0.692357
10	hsa64805 ( purinergic receptor P2Y12 )	0.674123

D05740 : Rizatriptan sulfate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D05740 ( Rizatriptan sulfate )

Rank	Target	Score	Validated	DrugBank
1	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.95499	1	1
2	hsa3350 ( 5-hydroxytryptamine receptor 1A )	0.882607	0	0
3	hsa3354 ( 5-hydroxytryptamine receptor 1E )	0.851109	0	0
4	hsa3361 ( 5-hydroxytryptamine receptor 5A )	0.824944	0	0
5	hsa148 ( adrenoceptor alpha 1A )	0.821523	0	0
6	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.798519	0	0
7	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.795745	0	0
8	hsa3357 ( 5-hydroxytryptamine receptor 2B )	0.794006	0	0
9	hsa150 ( adrenoceptor alpha 2A )	0.78352	0	0
10	hsa1814 ( dopamine receptor D3 )	0.757598	0	0

D05792 : Salmeterol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05792 ( Salmeterol )

Rank	Target	Score
1	hsa153 ( adrenoceptor beta 1 )	0.970721
2	hsa155 ( adrenoceptor beta 3 )	0.921864
3	hsa148 ( adrenoceptor alpha 1A )	0.715337
4	hsa3274 ( histamine receptor H2 )	0.665332
5	hsa3360 ( 5-hydroxytryptamine receptor 4 )	0.649515
6	hsa150 ( adrenoceptor alpha 2A )	0.628491
7	hsa1812 ( dopamine receptor D1 )	0.607727
8	hsa146 ( adrenoceptor alpha 1D )	0.600438
9	hsa151 ( adrenoceptor alpha 2B )	0.596143
10	hsa147 ( adrenoceptor alpha 1B )	0.566724

D05938 : Sufentanil (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D05938 ( Sufentanil )

Rank	Target	Score	Validated	DrugBank
1	hsa4986 ( opioid receptor kappa 1 )	0.916645	1	1
2	hsa4985 ( opioid receptor delta 1 )	0.834146	1	1
3	hsa185 ( angiotensin II receptor type 1 )	0.770519	0	0
4	hsa1128 ( cholinergic receptor muscarinic 1 )	0.738489	0	0
5	hsa3269 ( histamine receptor H1 )	0.698397	0	0
6	hsa1129 ( cholinergic receptor muscarinic 2 )	0.684327	0	0
7	hsa6752 ( somatostatin receptor 2 )	0.676517	0	0
8	hsa7201 ( thyrotropin releasing hormone receptor )	0.655866	0	0
9	hsa1813 ( dopamine receptor D2 )	0.648657	0	0
10	hsa3577 ( C-X-C motif chemokine receptor 1 )	0.642935	0	0

D06056 : Tegaserod (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D06056 ( Tegaserod )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.85986
2	hsa153 ( adrenoceptor beta 1 )	0.767239
3	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.740125
4	hsa1812 ( dopamine receptor D1 )	0.731822
5	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.731021
6	hsa3351 ( 5-hydroxytryptamine receptor 1B )	0.727055
7	hsa3362 ( 5-hydroxytryptamine receptor 6 )	0.726007
8	hsa3269 ( histamine receptor H1 )	0.725621
9	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.716038
10	hsa3358 ( 5-hydroxytryptamine receptor 2C )	0.708145

D06396 : Renzapride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D06396 ( Renzapride )

Rank	Target	Score
1	hsa154 ( adrenoceptor beta 2 )	0.797695
2	hsa3269 ( histamine receptor H1 )	0.744703
3	hsa1128 ( cholinergic receptor muscarinic 1 )	0.718604
4	hsa1812 ( dopamine receptor D1 )	0.705934
5	hsa3274 ( histamine receptor H2 )	0.698499
6	hsa148 ( adrenoceptor alpha 1A )	0.696978
7	hsa3356 ( 5-hydroxytryptamine receptor 2A )	0.695641
8	hsa153 ( adrenoceptor beta 1 )	0.683959
9	hsa3352 ( 5-hydroxytryptamine receptor 1D )	0.680044
10	hsa3355 ( 5-hydroxytryptamine receptor 1F )	0.67705

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