Predicted Drug-Target interactions

In total 412 out of top-10 predicted DTIs per drug were validated.
In total, 1367 validated new DTIs are known for ic dataset, however please note that at most 698 DTIs could be predicted (i.e., some drugs have more than 10 validated DTIs).

D00035 : Proline (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00035 ( Proline )

Rank	Target	Score
1	hsa6530 ( solute carrier family 6 member 2 )	0.988934
2	hsa6532 ( solute carrier family 6 member 4 )	0.9847
3	hsa6531 ( solute carrier family 6 member 3 )	0.971736
4	hsa6529 ( solute carrier family 6 member 1 )	0.878262
5	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.783687
6	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.721977
7	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.717633
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.70735
9	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.68618
10	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.684985

D00110 : Cocaine (Found 6 out of 7 validated targets)

Top-10 predicted interaction for: D00110 ( Cocaine )

Rank	Target	Score	Validated	KEGG
1	hsa11254 ( solute carrier family 6 member 14 )	0.889649	0	0
2	hsa6534 ( solute carrier family 6 member 7 )	0.857479	0	0
3	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.851284	1	1
4	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.826327	1	1
5	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.809486	1	1
6	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.78321	1	1
7	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.771827	1	1
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.73585	0	0
9	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.735154	1	1
10	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.702965	0	0

D00136 : Haloperidol (Found 0 out of 10 validated targets)

Top-10 predicted interaction for: D00136 ( Haloperidol )

Rank	Target	Score
1	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.929124
2	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.859885
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.826739
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.767087
5	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.762838
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.75893
7	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.747503
8	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.729317
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.722766
10	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.708484

D00195 : Codeine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00195 ( Codeine )

Rank	Target	Score
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.966487
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.885858
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.869743
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.781038
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.774668
6	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.772475
7	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.709062
8	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.706774
9	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.698164
10	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.689004

D00219 : Acetohexamide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00219 ( Acetohexamide )

Rank	Target	Score	Validated	KEGG
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.954905	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.92004	1	1
3	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.792878	0	0
4	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.743613	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.733117	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.720722	0	0
7	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.679285	0	0
8	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.660687	0	0
9	hsa6530 ( solute carrier family 6 member 2 )	0.657479	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.651395	0	0

D00225 : Alprazolam (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00225 ( Alprazolam )

Rank	Target	Score
1	hsa2741 ( glycine receptor alpha 1 )	0.882316
2	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.880492
3	hsa2743 ( glycine receptor beta )	0.836485
4	hsa2742 ( glycine receptor alpha 2 )	0.822204
5	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.72784
6	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.718624
7	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.7054
8	hsa6530 ( solute carrier family 6 member 2 )	0.70079
9	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.69807
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.67905

D00227 : Aminophylline (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00227 ( Aminophylline )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.814937
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.788279
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.784905
4	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.778113
5	hsa5026 ( purinergic receptor P2X 5 )	0.75007
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.704545
7	hsa5024 ( purinergic receptor P2X 3 )	0.698193
8	hsa5027 ( purinergic receptor P2X 7 )	0.695079
9	hsa5025 ( purinergic receptor P2X 4 )	0.693106
10	hsa9127 ( purinergic receptor P2X 6 )	0.686188

D00228 : Amoxapine (Found 2 out of 16 validated targets)

Top-10 predicted interaction for: D00228 ( Amoxapine )

Rank	Target	Score	Validated	DrugBank
1	hsa6531 ( solute carrier family 6 member 3 )	0.947958	1	1
2	hsa11254 ( solute carrier family 6 member 14 )	0.85083	0	0
3	hsa6534 ( solute carrier family 6 member 7 )	0.828202	0	0
4	hsa6529 ( solute carrier family 6 member 1 )	0.800311	0	0
5	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.784005	1	1
6	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.766937	0	0
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.736283	0	0
8	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.730352	0	0
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.709469	0	0
10	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.691462	0	0

D00234 : Astemizole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00234 ( Astemizole )

Rank	Target	Score
1	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.822765
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.775281
3	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.740724
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.73115
5	hsa90134 ( potassium voltage-gated channel subfamily H member 7 )	0.719094
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.717689
7	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.713586
8	hsa9424 ( potassium two pore domain channel subfamily K member 6 )	0.712692
9	hsa81033 ( potassium voltage-gated channel subfamily H member 6 )	0.710219
10	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.707433

D00252 : Carbamazepine (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00252 ( Carbamazepine )

Rank	Target	Score	Validated	KEGG
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.890235	1	1
2	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.832212	1	1
3	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.831545	1	1
4	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.806706	1	1
5	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.78525	0	0
6	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.741712	0	0
7	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.731286	0	0
8	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.700484	0	0
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.668822	0	0
10	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.652037	0	0

D00274 : Cisapride (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00274 ( Cisapride )

Rank	Target	Score
1	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.820102
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.771093
3	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.768458
4	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.75269
5	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.73489
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.719874
7	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.708509
8	hsa90134 ( potassium voltage-gated channel subfamily H member 7 )	0.705674
9	hsa81033 ( potassium voltage-gated channel subfamily H member 6 )	0.702087
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.697842

D00283 : Clozapine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00283 ( Clozapine )

Rank	Target	Score
1	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.927938
2	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.92472
3	hsa6530 ( solute carrier family 6 member 2 )	0.807926
4	hsa6532 ( solute carrier family 6 member 4 )	0.788612
5	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.757935
6	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.746146
7	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.714398
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.708379
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.686013
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.676444

D00293 : Diazepam (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00293 ( Diazepam )

Rank	Target	Score
1	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.774291
2	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.76732
3	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.767191
4	hsa6530 ( solute carrier family 6 member 2 )	0.718798
5	hsa8001 ( glycine receptor alpha 3 )	0.688431
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.664963
7	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.657369
8	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.633673
9	hsa6532 ( solute carrier family 6 member 4 )	0.618098
10	hsa6531 ( solute carrier family 6 member 3 )	0.609575

D00294 : Diazoxide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00294 ( Diazoxide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.888961	1	1	1
2	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.56603	0	0	0
3	hsa6530 ( solute carrier family 6 member 2 )	0.54134	0	0	0
4	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.475583	0	0	0
5	hsa6532 ( solute carrier family 6 member 4 )	0.464428	0	0	0
6	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.450156	0	0	0
7	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.415235	0	0	0
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.407425	0	0	0
9	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.406611	0	0	0
10	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.393881	0	0	0

D00303 : Disopyramide (Found 4 out of 6 validated targets)

Top-10 predicted interaction for: D00303 ( Disopyramide )

Rank	Target	Score	Validated	KEGG
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.907398	1	1
2	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.848813	1	1
3	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.846872	1	1
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.846741	0	0
5	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.823107	1	1
6	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.803963	0	0
7	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.770367	0	0
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.741661	0	0
9	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.687665	0	0
10	hsa40 ( acid sensing ion channel subunit 2 )	0.664345	0	0

D00319 : Felodipine (Found 8 out of 23 validated targets)

Top-10 predicted interaction for: D00319 ( Felodipine )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.955601	1	0	1
2	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.945709	0	0	0
3	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.941673	1	1	1
4	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.935418	1	0	1
5	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.926946	1	1	1
6	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.9139	1	1	1
7	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.908973	1	0	1
8	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.903636	1	0	1
9	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.894641	1	0	1
10	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.88802	0	0	0

D00326 : Fluoxetine (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00326 ( Fluoxetine )

Rank	Target	Score
1	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.865679
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.789185
3	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.7683
4	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.730474
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.722721
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.709451
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.702797
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.677351
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.676504
10	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.655586

D00329 : Flurazepam (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00329 ( Flurazepam )

Rank	Target	Score	Validated	DrugBank
1	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.874923	1	1
2	hsa2741 ( glycine receptor alpha 1 )	0.868117	0	0
3	hsa2743 ( glycine receptor beta )	0.831462	0	0
4	hsa2742 ( glycine receptor alpha 2 )	0.81198	0	0
5	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.734566	0	0
6	hsa6530 ( solute carrier family 6 member 2 )	0.714827	0	0
7	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.701018	0	0
8	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.699619	0	0
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.681393	0	0
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.677675	0	0

D00331 : Furosemide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00331 ( Furosemide )

Rank	Target	Score
1	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.876366
2	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.873876
3	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.873736
4	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.851068
5	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.826655
6	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.825009
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.824308
8	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.822804
9	hsa2562 ( gamma-aminobutyric acid type A receptor beta3 subunit )	0.8175
10	hsa2560 ( gamma-aminobutyric acid type A receptor beta1 subunit )	0.808804

D00332 : Gabapentin (Found 0 out of 21 validated targets)

Top-10 predicted interaction for: D00332 ( Gabapentin )

Rank	Target	Score
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.743221
2	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.590677
3	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.587723
4	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.584871
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.560957
6	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.546541
7	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.497239
8	hsa6530 ( solute carrier family 6 member 2 )	0.495639
9	hsa40 ( acid sensing ion channel subunit 2 )	0.48604
10	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.452014

D00335 : Glipizide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00335 ( Glipizide )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.913888	1	1	1	1
2	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.774638	0	0	0	0
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.765187	0	0	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.734329	0	0	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.728062	0	0	0	0
6	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.678479	0	0	0	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.642506	0	0	0	0
8	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.63438	0	0	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.633354	0	0	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.62927	0	0	0	0

D00336 : Glyburide (Found 1 out of 4 validated targets)

Top-10 predicted interaction for: D00336 ( Glyburide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.924312	1	1	1
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.851648	0	0	0
3	hsa6261 ( ryanodine receptor 1 )	0.78524	0	0	0
4	hsa6263 ( ryanodine receptor 3 )	0.768128	0	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.753254	0	0	0
6	hsa6262 ( ryanodine receptor 2 )	0.751355	0	0	0
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.74191	0	0	0
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.689231	0	0	0
9	hsa6530 ( solute carrier family 6 member 2 )	0.664543	0	0	0
10	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.655357	0	0	0

D00338 : Halazepam (Found 10 out of 15 validated targets)

Top-10 predicted interaction for: D00338 ( Halazepam )

Rank	Target	Score	Validated	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.958636	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.955534	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.955476	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.95384	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.953358	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.892353	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.888597	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.888078	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.878844	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.878776	1	1

D00340 : Hydrochlorothiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00340 ( Hydrochlorothiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.86595
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.759429
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.757191
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.743833
5	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.702124
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.696036
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.68729
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.683674
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.659531
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.638495

D00345 : Indapamide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00345 ( Indapamide )

Rank	Target	Score
1	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.773364
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.764982
3	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.747805
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.745761
5	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.738893
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.714169
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.711882
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.711098
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.701478
10	hsa6530 ( solute carrier family 6 member 2 )	0.692791

D00349 : Isradipine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00349 ( Isradipine )

Rank	Target	Score	Validated	DrugBank
1	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.971273	0	0
2	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.944426	0	0
3	hsa782 ( calcium voltage-gated channel auxiliary subunit beta 1 )	0.934002	0	0
4	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.929054	0	0
5	hsa9254 ( calcium voltage-gated channel auxiliary subunit alpha2delta 2 )	0.916037	1	1
6	hsa59284 ( calcium voltage-gated channel auxiliary subunit gamma 7 )	0.908471	0	0
7	hsa27092 ( calcium voltage-gated channel auxiliary subunit gamma 4 )	0.908189	0	0
8	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.904624	0	0
9	hsa784 ( calcium voltage-gated channel auxiliary subunit beta 3 )	0.894488	0	0
10	hsa3708 ( inositol 1,4,5-trisphosphate receptor type 1 )	0.887863	0	0

D00351 : Ketoconazole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00351 ( Ketoconazole )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.9056
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.892684
3	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.859229
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.824566
5	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.803749
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.800371
7	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.78114
8	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.768721
9	hsa3747 ( potassium voltage-gated channel subfamily C member 2 )	0.760442
10	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.748767

D00354 : Lamotrigine (Found 5 out of 37 validated targets)

Top-10 predicted interaction for: D00354 ( Lamotrigine )

Rank	Target	Score	Validated	Matador
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.976322	1	1
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.93476	0	0
3	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.825511	1	1
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.766604	1	1
5	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.74731	0	0
6	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.69046	0	0
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.681164	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.67221	0	0
9	hsa9311 ( acid sensing ion channel subunit 3 )	0.662876	1	1
10	hsa55515 ( acid sensing ion channel subunit family member 4 )	0.65659	1	1

D00358 : Lidocaine (Found 1 out of 9 validated targets)

Top-10 predicted interaction for: D00358 ( Lidocaine )

Rank	Target	Score	Validated	Matador
1	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.797697	1	1
2	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.796453	0	0
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.726833	0	0
4	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.712517	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.703739	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.664474	0	0
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.620918	0	0
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.611827	0	0
9	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.592274	0	0
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.589316	0	0

D00364 : Loratadine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00364 ( Loratadine )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.891457
2	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.880795
3	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.870976
4	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.865171
5	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.862275
6	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.853827
7	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.850728
8	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.845168
9	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.839836
10	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.830108

D00367 : Mazindol (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00367 ( Mazindol )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa6532 ( solute carrier family 6 member 4 )	0.975173	1	1	1
2	hsa11254 ( solute carrier family 6 member 14 )	0.871271	0	0	0
3	hsa6534 ( solute carrier family 6 member 7 )	0.849153	0	0	0
4	hsa6529 ( solute carrier family 6 member 1 )	0.83443	0	0	0
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.784722	0	0	0
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.766521	0	0	0
7	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.720052	0	0	0
8	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.687313	0	0	0
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.679512	0	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.677999	0	0	0

D00373 : Thioridazine (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00373 ( Thioridazine )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.914161
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.901469
3	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.852416
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.850263
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.811981
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.802151
7	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.783863
8	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.759238
9	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.742332
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.734055

D00379 : Tolazamide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00379 ( Tolazamide )

Rank	Target	Score	Validated	KEGG
1	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.90547	1	1
2	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.772668	0	0
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.745691	0	0
4	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.744007	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.739349	0	0
6	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.696152	0	0
7	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.650093	0	0
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.643702	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.631673	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.628906	0	0

D00380 : Tolbutamide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00380 ( Tolbutamide )

Rank	Target	Score	Validated	KEGG
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.945084	1	1
2	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.847454	0	0
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.718141	0	0
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.714966	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.691887	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.675768	0	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.660411	0	0
8	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.643411	0	0
9	hsa6532 ( solute carrier family 6 member 4 )	0.628888	0	0
10	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.628742	0	0

D00392 : Trimethadione (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00392 ( Trimethadione )

Rank	Target	Score
1	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.97175
2	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.963862
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.784597
4	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.782328
5	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.771807
6	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.753246
7	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.745733
8	hsa6261 ( ryanodine receptor 1 )	0.737077
9	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.719115
10	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.717416

D00394 : Trimipramine (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00394 ( Trimipramine )

Rank	Target	Score	Validated	DrugBank
1	hsa6531 ( solute carrier family 6 member 3 )	0.934614	1	1
2	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.90326	0	0
3	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.83417	0	0
4	hsa11254 ( solute carrier family 6 member 14 )	0.830485	0	0
5	hsa6534 ( solute carrier family 6 member 7 )	0.807744	0	0
6	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.796939	0	0
7	hsa6529 ( solute carrier family 6 member 1 )	0.781356	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.745085	0	0
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.7197	1	1
10	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.718191	0	0

D00418 : Minoxidil (Found 6 out of 72 validated targets)

Top-10 predicted interaction for: D00418 ( Minoxidil )

Rank	Target	Score	Validated	KEGG	Matador
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.916301	1	1	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.897581	1	1	0
3	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.762545	0	0	0
4	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.747868	0	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.732104	1	0	1
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.724671	1	0	1
7	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.714934	1	0	1
8	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.682783	0	0	0
9	hsa6530 ( solute carrier family 6 member 2 )	0.675518	0	0	0
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.664221	1	0	1

D00437 : Nifedipine (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00437 ( Nifedipine )

Rank	Target	Score
1	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.695623
2	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.670617
3	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.645725
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.58009
5	hsa56659 ( potassium two pore domain channel subfamily K member 13 )	0.560955
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.552418
7	hsa6530 ( solute carrier family 6 member 2 )	0.552147
8	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.534166
9	hsa6340 ( sodium channel epithelial 1 gamma subunit )	0.515923
10	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.512871

D00438 : Nimodipine (Found 2 out of 4 validated targets)

Top-10 predicted interaction for: D00438 ( Nimodipine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.987873	1	1	1
2	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.976376	0	0	0
3	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.963362	0	0	0
4	hsa782 ( calcium voltage-gated channel auxiliary subunit beta 1 )	0.932148	1	0	1
5	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.93045	0	0	0
6	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.927176	0	0	0
7	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.915094	0	0	0
8	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.912943	0	0	0
9	hsa9254 ( calcium voltage-gated channel auxiliary subunit alpha2delta 2 )	0.911115	0	0	0
10	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.908606	0	0	0

D00451 : Sumatriptan (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00451 ( Sumatriptan )

Rank	Target	Score
1	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.938787
2	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.936725
3	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.786975
4	hsa6530 ( solute carrier family 6 member 2 )	0.761222
5	hsa6532 ( solute carrier family 6 member 4 )	0.750611
6	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.742047
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.728947
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.693103
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.657727
10	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.655975

D00456 : Ondansetron (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00456 ( Ondansetron )

Rank	Target	Score	Validated	KEGG
1	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.965364	1	1
2	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.956755	1	1
3	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.912565	1	1
4	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.90872	1	1
5	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.807317	0	0
6	hsa6530 ( solute carrier family 6 member 2 )	0.790162	0	0
7	hsa6532 ( solute carrier family 6 member 4 )	0.771855	0	0
8	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.769606	0	0
9	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.747065	0	0
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.727158	0	0

D00464 : Oxazepam (Found 10 out of 15 validated targets)

Top-10 predicted interaction for: D00464 ( Oxazepam )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.947145	1	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.943557	1	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.942975	1	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.940733	1	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.94072	1	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.85325	1	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.851405	1	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.849526	1	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.831157	1	1	1
10	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.829616	1	1	1

D00474 : Primidone (Found 9 out of 17 validated targets)

Top-10 predicted interaction for: D00474 ( Primidone )

Rank	Target	Score	Validated	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.940017	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.935671	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.934987	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.93322	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.932913	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.826738	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.826368	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.825273	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.798744	1	1
10	hsa2741 ( glycine receptor alpha 1 )	0.796338	0	0

D00477 : Procainamide hydrochloride (Found 2 out of 10 validated targets)

Top-10 predicted interaction for: D00477 ( Procainamide hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.973576	1	1
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.950547	0	0
3	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.813704	0	0
4	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.756403	1	1
5	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.710896	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.68825	0	0
7	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.671587	0	0
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.663373	0	0
9	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.659036	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.657788	0	0

D00480 : Promethazine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00480 ( Promethazine hydrochloride )

Rank	Target	Score
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.97374
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.94131
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.870739
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.851743
5	hsa6530 ( solute carrier family 6 member 2 )	0.808228
6	hsa6532 ( solute carrier family 6 member 4 )	0.789529
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.784655
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.727134
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.719725
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.706185

D00495 : Paramethadione (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00495 ( Paramethadione )

Rank	Target	Score
1	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.984123
2	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.975034
3	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.815508
4	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.812264
5	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.786811
6	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.785186
7	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.783052
8	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.767555
9	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.766756
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.74067

D00499 : Pentobarbital (Found 2 out of 10 validated targets)

Top-10 predicted interaction for: D00499 ( Pentobarbital )

Rank	Target	Score	Validated	DrugBank
1	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.887386	0	0
2	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.876167	0	0
3	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.875124	1	1
4	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.7997	0	0
5	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.797982	0	0
6	hsa2741 ( glycine receptor alpha 1 )	0.785683	0	0
7	hsa2743 ( glycine receptor beta )	0.718292	0	0
8	hsa2742 ( glycine receptor alpha 2 )	0.712527	0	0
9	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.662887	1	1
10	hsa6530 ( solute carrier family 6 member 2 )	0.640672	0	0

D00504 : Phenacemide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00504 ( Phenacemide )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.986129
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.971803
3	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.969702
4	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.965211
5	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.962377
6	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.95857
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.957941
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.923972
9	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.808738
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.774086

D00512 : Phenytoin (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00512 ( Phenytoin )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.747702	1	1	1
2	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.605337	0	0	0
3	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.58995	1	1	0
4	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.585449	1	1	0
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.551607	0	0	0
6	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.544533	1	1	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.510659	0	0	0
8	hsa40 ( acid sensing ion channel subunit 2 )	0.503611	0	0	0
9	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.492144	0	0	0
10	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.478764	0	0	0

D00513 : Pindolol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00513 ( Pindolol )

Rank	Target	Score
1	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.936922
2	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.934421
3	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.773644
4	hsa6530 ( solute carrier family 6 member 2 )	0.763731
5	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.763112
6	hsa6532 ( solute carrier family 6 member 4 )	0.745911
7	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.72888
8	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.67146
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.661337
10	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.657625

D00519 : Chlorothiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00519 ( Chlorothiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.845812
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.759255
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.7562
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.752036
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.692616
6	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.686098
7	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.685364
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.679923
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.668187
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.647903

D00521 : Terfenadine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00521 ( Terfenadine )

Rank	Target	Score
1	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.814779
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.765342
3	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.744315
4	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.730139
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.729988
6	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.728412
7	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.728006
8	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.719839
9	hsa90134 ( potassium voltage-gated channel subfamily H member 7 )	0.715181
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.712077

D00524 : Carbachol (Found 0 out of 27 validated targets)

Top-10 predicted interaction for: D00524 ( Carbachol )

Rank	Target	Score
1	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.964678
2	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.96399
3	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.960313
4	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.878088
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.81521
6	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.769318
7	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.747931
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.732136
9	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.717318
10	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.711011

D00528 : Caffeine (Found 1 out of 36 validated targets)

Top-10 predicted interaction for: D00528 ( Caffeine )

Rank	Target	Score	Validated	Matador
1	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.955604	0	0
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.921328	0	0
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.776884	0	0
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.769335	0	0
5	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.749916	1	1
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.71517	0	0
7	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.687791	0	0
8	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.684463	0	0
9	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.683399	0	0
10	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.678848	0	0

D00530 : Zaleplon (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00530 ( Zaleplon )

Rank	Target	Score
1	hsa2741 ( glycine receptor alpha 1 )	0.846536
2	hsa2743 ( glycine receptor beta )	0.804398
3	hsa2742 ( glycine receptor alpha 2 )	0.782759
4	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.703945
5	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.69364
6	hsa6530 ( solute carrier family 6 member 2 )	0.674694
7	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.674088
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.632815
9	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.627175
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.626174

D00533 : Oxcarbazepine (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D00533 ( Oxcarbazepine )

Rank	Target	Score	Validated	KEGG
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.956998	0	0
2	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.953485	1	1
3	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.95238	1	1
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.947299	1	1
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.928957	1	1
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.927283	1	1
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.917014	1	1
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.889078	0	0
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.75189	0	0
10	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.723377	0	0

D00536 : Felbamate (Found 5 out of 31 validated targets)

Top-10 predicted interaction for: D00536 ( Felbamate )

Rank	Target	Score	Validated	Matador
1	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.891551	1	1
2	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.861639	1	1
3	hsa8001 ( glycine receptor alpha 3 )	0.818774	0	0
4	hsa6532 ( solute carrier family 6 member 4 )	0.774009	0	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.773376	0	0
6	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.731288	0	0
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.729882	1	1
8	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.722229	0	0
9	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.71627	1	1
10	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.716244	1	1

D00537 : Topiramate (Found 9 out of 31 validated targets)

Top-10 predicted interaction for: D00537 ( Topiramate )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.939079	1	1	0
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.891145	1	1	0
3	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.89083	1	1	0
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.885906	1	1	0
5	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.878236	1	1	0
6	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.866461	1	1	0
7	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.853005	1	0	1
8	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.846249	0	0	0
9	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.843764	1	0	1
10	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.840097	1	0	1

D00538 : Zonisamide (Found 4 out of 5 validated targets)

Top-10 predicted interaction for: D00538 ( Zonisamide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.95078	1	1	1
2	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.828942	1	1	1
3	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.820741	1	1	0
4	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.797569	1	1	1
5	hsa40 ( acid sensing ion channel subunit 2 )	0.713138	0	0	0
6	hsa5310 ( polycystin 1, transient receptor potential channel interacting )	0.684373	0	0	0
7	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.683716	0	0	0
8	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.660511	0	0	0
9	hsa41 ( acid sensing ion channel subunit 1 )	0.655843	0	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.638774	0	0	0

D00539 : Ethosuximide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00539 ( Ethosuximide )

Rank	Target	Score
1	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.801063
2	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.793441
3	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.789903
4	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.766788
5	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.762196
6	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.760654
7	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.740855
8	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.737727
9	hsa5310 ( polycystin 1, transient receptor potential channel interacting )	0.731102
10	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.713135

D00542 : Halothane (Found 4 out of 23 validated targets)

Top-10 predicted interaction for: D00542 ( Halothane )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa6261 ( ryanodine receptor 1 )	0.853666	1	0	1
2	hsa6263 ( ryanodine receptor 3 )	0.843711	1	0	1
3	hsa6262 ( ryanodine receptor 2 )	0.790377	1	0	1
4	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.764386	0	0	0
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.664503	0	0	0
6	hsa2742 ( glycine receptor alpha 2 )	0.586133	0	0	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.573278	0	0	0
8	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.552702	0	0	0
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.54704	0	0	0
10	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.535648	1	1	1

D00543 : Enflurane (Found 9 out of 16 validated targets)

Top-10 predicted interaction for: D00543 ( Enflurane )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa2742 ( glycine receptor alpha 2 )	0.878594	0	0	0
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.865319	1	1	1
3	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.864571	1	1	1
4	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.860136	1	1	1
5	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.854844	1	1	1
6	hsa2743 ( glycine receptor beta )	0.850679	1	1	0
7	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.845622	1	1	1
8	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.788497	1	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.788448	1	1	1
10	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.773603	1	1	1

D00544 : Methoxyflurane (Found 7 out of 13 validated targets)

Top-10 predicted interaction for: D00544 ( Methoxyflurane )

Rank	Target	Score	Validated	DrugBank
1	hsa2742 ( glycine receptor alpha 2 )	0.872497	0	0
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.848292	1	1
3	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.847344	1	1
4	hsa2743 ( glycine receptor beta )	0.842586	0	0
5	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.842388	1	1
6	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.836372	1	1
7	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.826375	1	1
8	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.773608	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.773576	1	1
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.768177	0	0

D00545 : Isoflurane (Found 2 out of 5 validated targets)

Top-10 predicted interaction for: D00545 ( Isoflurane )

Rank	Target	Score	Validated	Matador
1	hsa2742 ( glycine receptor alpha 2 )	0.887687	1	1
2	hsa2743 ( glycine receptor beta )	0.88615	1	1
3	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.848577	0	0
4	hsa8001 ( glycine receptor alpha 3 )	0.678807	0	0
5	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.668767	0	0
6	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.639852	0	0
7	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.62359	0	0
8	hsa6530 ( solute carrier family 6 member 2 )	0.620397	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.598765	0	0
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.590089	0	0

D00546 : Desflurane (Found 8 out of 13 validated targets)

Top-10 predicted interaction for: D00546 ( Desflurane )

Rank	Target	Score	Validated	DrugBank
1	hsa2742 ( glycine receptor alpha 2 )	0.87753	0	0
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.875704	1	1
3	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.874922	1	1
4	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.871216	1	1
5	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.86611	1	1
6	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.857678	1	1
7	hsa2743 ( glycine receptor beta )	0.853699	0	0
8	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.812772	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.811985	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.798629	1	1

D00547 : Sevoflurane (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00547 ( Sevoflurane )

Rank	Target	Score
1	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.869443
2	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.750641
3	hsa8001 ( glycine receptor alpha 3 )	0.740735
4	hsa6530 ( solute carrier family 6 member 2 )	0.666059
5	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.606516
6	hsa2897 ( glutamate ionotropic receptor kainate type subunit 1 )	0.583207
7	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.582989
8	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.568328
9	hsa6532 ( solute carrier family 6 member 4 )	0.561178
10	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.560243

D00548 : Etomidate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00548 ( Etomidate )

Rank	Target	Score
1	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.86201
2	hsa2741 ( glycine receptor alpha 1 )	0.843492
3	hsa2743 ( glycine receptor beta )	0.802124
4	hsa2742 ( glycine receptor alpha 2 )	0.782986
5	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.69187
6	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.671782
7	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.671371
8	hsa6530 ( solute carrier family 6 member 2 )	0.648332
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.64802
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.647648

D00549 : Propofol (Found 0 out of 10 validated targets)

Top-10 predicted interaction for: D00549 ( Propofol )

Rank	Target	Score
1	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.767268
2	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.75952
3	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.749984
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.745543
5	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.710345
6	hsa6530 ( solute carrier family 6 member 2 )	0.706299
7	hsa8001 ( glycine receptor alpha 3 )	0.693269
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.673208
9	hsa6532 ( solute carrier family 6 member 4 )	0.620426
10	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.608739

D00550 : Midazolam (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00550 ( Midazolam )

Rank	Target	Score	Validated	DrugBank
1	hsa2570 ( gamma-aminobutyric acid type A receptor rho2 subunit )	0.890114	1	1
2	hsa2741 ( glycine receptor alpha 1 )	0.872689	0	0
3	hsa2743 ( glycine receptor beta )	0.829992	0	0
4	hsa2742 ( glycine receptor alpha 2 )	0.811343	0	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.735544	0	0
6	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.713285	0	0
7	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.696578	0	0
8	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.681328	0	0
9	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.678355	0	0
10	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.677832	0	0

D00552 : Benzocaine (Found 5 out of 5 validated targets)

Top-10 predicted interaction for: D00552 ( Benzocaine )

Rank	Target	Score	Validated	KEGG
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.9645	1	1
2	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.917409	1	1
3	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.864065	1	1
4	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.860247	1	1
5	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.838561	1	1
6	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.828177	0	0
7	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.770018	0	0
8	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.744226	0	0
9	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.741453	0	0
10	hsa40 ( acid sensing ion channel subunit 2 )	0.676932	0	0

D00553 : Prilocaine (Found 5 out of 6 validated targets)

Top-10 predicted interaction for: D00553 ( Prilocaine )

Rank	Target	Score	Validated	KEGG
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.976596	1	1
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.972393	1	1
3	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.971735	1	1
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.96983	0	0
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.961552	1	1
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.959913	0	0
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.953796	0	0
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.928952	0	0
9	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.7503	1	1
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.74542	0	0

D00560 : Pimozide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00560 ( Pimozide )

Rank	Target	Score	Validated	DrugBank
1	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.823786	1	1
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.721176	0	0
3	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.611682	0	0
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.562723	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.553401	0	0
6	hsa56659 ( potassium two pore domain channel subfamily K member 13 )	0.540849	0	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.53971	0	0
8	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.520876	0	0
9	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.513396	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.513281	0	0

D00563 : Mirtazapine (Found 6 out of 7 validated targets)

Top-10 predicted interaction for: D00563 ( Mirtazapine )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.963786	1	1	0
2	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.955764	1	1	0
3	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.905305	1	1	0
4	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.900624	1	1	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.824518	1	0	1
6	hsa6532 ( solute carrier family 6 member 4 )	0.810904	1	0	1
7	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.798283	0	0	0
8	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.743091	0	0	0
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.696825	0	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.694978	0	0	0

D00574 : Aminoglutethimide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00574 ( Aminoglutethimide )

Rank	Target	Score
1	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.941173
2	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.893672
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.8737
4	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.848087
5	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.846103
6	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.841056
7	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.809888
8	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.80331
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.789439
10	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.788762

D00593 : Glimepiride (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00593 ( Glimepiride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.948154	1	0	1
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.915822	1	1	1
3	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.779849	0	0	0
4	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.750197	0	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.736279	0	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.729443	0	0	0
7	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.679748	0	0	0
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.673584	0	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.673051	0	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.663718	0	0	0

D00594 : Repaglinide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D00594 ( Repaglinide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.92645	0	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.883678	1	1	1
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.816168	0	0	0
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.771734	0	0	0
5	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.750972	0	0	0
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.73785	0	0	0
7	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.719494	0	0	0
8	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.71626	0	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.682454	0	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.665537	0	0	0

D00607 : Guanadrel sulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00607 ( Guanadrel sulfate )

Rank	Target	Score
1	hsa6532 ( solute carrier family 6 member 4 )	0.965793
2	hsa6531 ( solute carrier family 6 member 3 )	0.957051
3	hsa11254 ( solute carrier family 6 member 14 )	0.84161
4	hsa6534 ( solute carrier family 6 member 7 )	0.817621
5	hsa6529 ( solute carrier family 6 member 1 )	0.797115
6	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.748788
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.742894
8	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.73025
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.700722
10	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.699118

D00611 : Mecamylamine hydrochloride (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D00611 ( Mecamylamine hydrochloride )

Rank	Target	Score	Validated	KEGG	Matador
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.969627	1	1	1
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.879936	1	1	1
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.862807	0	0	0
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.795789	0	0	0
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.771892	1	1	0
6	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.714263	0	0	0
7	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.712232	0	0	0
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.704974	1	1	0
9	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.696377	0	0	0
10	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.688184	0	0	0

D00615 : Amlodipine besylate (Found 4 out of 5 validated targets)

Top-10 predicted interaction for: D00615 ( Amlodipine besylate )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.94111	1	0	1
2	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.92772	0	0	0
3	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.924116	0	0	0
4	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.921714	1	1	1
5	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.904916	1	1	0
6	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.874697	1	1	0
7	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.873312	0	0	0
8	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.865928	0	0	0
9	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.855905	0	0	0
10	hsa782 ( calcium voltage-gated channel auxiliary subunit beta 1 )	0.854774	0	0	0

D00616 : Diltiazem hydrochloride (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D00616 ( Diltiazem hydrochloride )

Rank	Target	Score	Validated	KEGG
1	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.938098	0	0
2	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.909023	1	1
3	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.902748	0	0
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.902101	0	0
5	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.869009	0	0
6	hsa3747 ( potassium voltage-gated channel subfamily C member 2 )	0.836308	0	0
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.809855	0	0
8	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.798466	0	0
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.771478	0	0
10	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.733536	0	0

D00617 : Nicardipine hydrochloride (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00617 ( Nicardipine hydrochloride )

Rank	Target	Score	Validated	DrugBank
1	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.916038	0	0
2	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.910829	0	0
3	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.901247	0	0
4	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.89464	1	1
5	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.893225	0	0
6	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.872893	1	1
7	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.852872	0	0
8	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.84336	0	0
9	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.837343	0	0
10	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.835671	0	0

D00618 : Nisoldipine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00618 ( Nisoldipine )

Rank	Target	Score
1	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.694272
2	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.655559
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.647692
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.579472
5	hsa56659 ( potassium two pore domain channel subfamily K member 13 )	0.559771
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.553701
7	hsa6340 ( sodium channel epithelial 1 gamma subunit )	0.546757
8	hsa6530 ( solute carrier family 6 member 2 )	0.53538
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.533067
10	hsa6324 ( sodium voltage-gated channel beta subunit 1 )	0.519301

D00619 : Verapamil hydrochloride (Found 10 out of 122 validated targets)

Top-10 predicted interaction for: D00619 ( Verapamil hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.950995	1	1	1	1
2	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.929047	1	0	0	1
3	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.917527	1	0	0	1
4	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.902834	1	0	1	1
5	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.896146	1	1	1	1
6	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.892087	1	0	0	1
7	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.885799	1	0	0	1
8	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.882314	1	0	0	1
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.85526	1	0	0	1
10	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.851592	1	0	1	1

D00629 : Nitrendipine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00629 ( Nitrendipine )

Rank	Target	Score
1	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.701304
2	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.676411
3	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.650964
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.61177
5	hsa56659 ( potassium two pore domain channel subfamily K member 13 )	0.562142
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.55467
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.543686
8	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.542654
9	hsa6530 ( solute carrier family 6 member 2 )	0.540834
10	hsa6340 ( sodium channel epithelial 1 gamma subunit )	0.518005

D00631 : Bepridil hydrochloride (Found 2 out of 49 validated targets)

Top-10 predicted interaction for: D00631 ( Bepridil hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.87222	0	0	0
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.858448	0	0	0
3	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.855338	1	1	1
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.834299	0	0	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.808199	0	0	0
6	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.805932	0	0	0
7	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.772409	1	1	0
8	hsa6532 ( solute carrier family 6 member 4 )	0.771533	0	0	0
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.764415	0	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.752413	0	0	0

D00633 : Dopamine hydrochloride (Found 0 out of 3 validated targets)

Top-10 predicted interaction for: D00633 ( Dopamine hydrochloride )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.802381
2	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.726925
3	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.697565
4	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.695836
5	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.686825
6	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.686778
7	hsa6261 ( ryanodine receptor 1 )	0.683828
8	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.676776
9	hsa2741 ( glycine receptor alpha 1 )	0.673835
10	hsa8001 ( glycine receptor alpha 3 )	0.664989

D00636 : Amiodarone hydrochloride (Found 0 out of 10 validated targets)

Top-10 predicted interaction for: D00636 ( Amiodarone hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.940225
2	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.920528
3	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.891493
4	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.884539
5	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.86173
6	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.8549
7	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.833729
8	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.82249
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.821237
10	hsa3747 ( potassium voltage-gated channel subfamily C member 2 )	0.806464

D00638 : Flecainide acetate (Found 1 out of 4 validated targets)

Top-10 predicted interaction for: D00638 ( Flecainide acetate )

Rank	Target	Score	Validated	KEGG
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.951505	0	0
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.92935	0	0
3	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.88519	0	0
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.808794	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.799033	0	0
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.747488	0	0
7	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.710233	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.704492	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.703214	0	0
10	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.700993	1	1

D00639 : Mexiletine hydrochloride (Found 2 out of 10 validated targets)

Top-10 predicted interaction for: D00639 ( Mexiletine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.978837	1	1
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.952055	0	0
3	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.81315	0	0
4	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.793518	1	1
5	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.750014	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.717781	0	0
7	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.69626	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.659314	0	0
9	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.651215	0	0
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.612249	0	0

D00640 : Propafenone hydrochloride (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00640 ( Propafenone hydrochloride )

Rank	Target	Score
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.957755
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.810058
3	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.786655
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.714586
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.712433
6	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.687058
7	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.679643
8	hsa9424 ( potassium two pore domain channel subfamily K member 6 )	0.673947
9	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.671973
10	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.671326

D00642 : Quinidine gluconate (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D00642 ( Quinidine gluconate )

Rank	Target	Score	Validated	DrugBank
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.907586	0	0
2	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.899129	0	0
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.889687	1	1
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.807111	0	0
5	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.794827	0	0
6	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.790506	0	0
7	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.744829	0	0
8	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.736237	0	0
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.731125	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.717802	0	0

D00647 : Dofetilide (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00647 ( Dofetilide )

Rank	Target	Score
1	hsa9424 ( potassium two pore domain channel subfamily K member 6 )	0.862996
2	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.862872
3	hsa3756 ( potassium voltage-gated channel subfamily H member 1 )	0.859274
4	hsa83795 ( potassium two pore domain channel subfamily K member 16 )	0.80294
5	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.797808
6	hsa90134 ( potassium voltage-gated channel subfamily H member 7 )	0.746961
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.743062
8	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.731479
9	hsa81033 ( potassium voltage-gated channel subfamily H member 6 )	0.725576
10	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.722758

D00648 : Ibutilide fumarate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00648 ( Ibutilide fumarate )

Rank	Target	Score
1	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.882406
2	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.861544
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.844301
4	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.840006
5	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.837741
6	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.818083
7	hsa3756 ( potassium voltage-gated channel subfamily H member 1 )	0.771487
8	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.757339
9	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.756396
10	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.753698

D00649 : Amiloride hydrochloride (Found 6 out of 31 validated targets)

Top-10 predicted interaction for: D00649 ( Amiloride hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa6330 ( sodium voltage-gated channel beta subunit 4 )	0.930276	1	1
2	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.929398	1	1
3	hsa55800 ( sodium voltage-gated channel beta subunit 3 )	0.899396	1	1
4	hsa6324 ( sodium voltage-gated channel beta subunit 1 )	0.845717	1	1
5	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.834395	1	1
6	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.751104	1	1
7	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.750113	0	0
8	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.742095	0	0
9	hsa6530 ( solute carrier family 6 member 2 )	0.703903	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.690101	0	0

D00650 : Bendroflumethiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00650 ( Bendroflumethiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.845259
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.761797
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.761578
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.760287
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.706386
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.692748
7	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.686765
8	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.677925
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.672041
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.653517

D00651 : Benzthiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00651 ( Benzthiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.843834
2	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.807249
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.755992
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.744324
5	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.693932
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.679911
7	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.679556
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.672786
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.670145
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.654907

D00654 : Hydroflumethiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00654 ( Hydroflumethiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.84915
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.760948
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.756197
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.746746
5	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.690577
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.686886
7	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.686665
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.674881
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.664413
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.643153

D00656 : Methyclothiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00656 ( Methyclothiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.863935
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.759263
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.757327
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.748443
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.702924
6	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.697838
7	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.694195
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.680313
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.66176
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.642297

D00658 : Trichlormethiazide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00658 ( Trichlormethiazide )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.859855
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.760016
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.758479
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.742657
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.700154
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.693037
7	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.689712
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.681732
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.664112
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.643127

D00677 : Granisetron hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00677 ( Granisetron hydrochloride )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.766479
2	hsa2741 ( glycine receptor alpha 1 )	0.725745
3	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.724831
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.714335
5	hsa8001 ( glycine receptor alpha 3 )	0.711826
6	hsa2742 ( glycine receptor alpha 2 )	0.703551
7	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.698444
8	hsa6530 ( solute carrier family 6 member 2 )	0.69231
9	hsa6261 ( ryanodine receptor 1 )	0.678368
10	hsa6532 ( solute carrier family 6 member 4 )	0.671329

D00678 : Ondansetron hydrochloride hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00678 ( Ondansetron hydrochloride hydrate )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.7809
2	hsa6530 ( solute carrier family 6 member 2 )	0.742269
3	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.74172
4	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.733133
5	hsa6532 ( solute carrier family 6 member 4 )	0.72381
6	hsa6261 ( ryanodine receptor 1 )	0.700444
7	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.693932
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.683659
9	hsa8001 ( glycine receptor alpha 3 )	0.679126
10	hsa2741 ( glycine receptor alpha 1 )	0.6788

D00694 : Clorazepate dipotassium (Found 10 out of 13 validated targets)

Top-10 predicted interaction for: D00694 ( Clorazepate dipotassium )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.956629	1	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.953429	1	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.953156	1	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.951327	1	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.951048	1	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.876394	1	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.873995	1	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.873689	1	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.858162	1	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.856419	1	1	1

D00697 : Flumazenil (Found 10 out of 13 validated targets)

Top-10 predicted interaction for: D00697 ( Flumazenil )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.948773	1	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.945075	1	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.945029	1	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.942991	1	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.942567	1	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.858136	1	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.85677	1	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.854583	1	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.839268	1	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.837985	1	1	1

D00704 : Ethchlorvynol (Found 9 out of 13 validated targets)

Top-10 predicted interaction for: D00704 ( Ethchlorvynol )

Rank	Target	Score	Validated	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.944619	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.941135	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.940424	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.938525	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.937808	1	1
6	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.838919	1	1
7	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.836938	1	1
8	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.836588	1	1
9	hsa2741 ( glycine receptor alpha 1 )	0.834024	0	0
10	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.814066	1	1

D00708 : Ethotoin (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00708 ( Ethotoin )

Rank	Target	Score
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.961813
2	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.955887
3	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.95348
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.949405
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.936231
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.932979
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.923457
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.88546
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.727956
10	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.71035

D00709 : Levetiracetam (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00709 ( Levetiracetam )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.973636
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.954678
3	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.954436
4	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.94641
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.940374
6	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.937299
7	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.932226
8	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.932147
9	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.926393
10	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.852543

D00711 : Ketamine hydrochloride (Found 9 out of 18 validated targets)

Top-10 predicted interaction for: D00711 ( Ketamine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.848193	1	1
2	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.843368	1	1
3	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.838687	1	1
4	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.797821	1	1
5	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.78541	1	1
6	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.777286	1	1
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.773667	1	1
8	hsa2562 ( gamma-aminobutyric acid type A receptor beta3 subunit )	0.764346	1	1
9	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.760914	1	1
10	hsa2741 ( glycine receptor alpha 1 )	0.758519	0	0

D00726 : Metoclopramide (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00726 ( Metoclopramide )

Rank	Target	Score	Validated	KEGG
1	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.955479	0	0
2	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.790065	1	1
3	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.784197	1	1
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.775571	0	0
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.69478	0	0
6	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.688024	0	0
7	hsa6530 ( solute carrier family 6 member 2 )	0.683219	0	0
8	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.672123	0	0
9	hsa6532 ( solute carrier family 6 member 4 )	0.669418	0	0
10	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.629975	0	0

D00732 : Chloroprocaine hydrochloride (Found 1 out of 4 validated targets)

Top-10 predicted interaction for: D00732 ( Chloroprocaine hydrochloride )

Rank	Target	Score	Validated	DrugBank
1	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.786675	0	0
2	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.774245	0	0
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.718483	0	0
4	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.705355	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.674164	0	0
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.658572	1	1
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.648816	0	0
8	hsa6261 ( ryanodine receptor 1 )	0.635026	0	0
9	hsa6263 ( ryanodine receptor 3 )	0.603661	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.60005	0	0

D00733 : Dibucaine (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D00733 ( Dibucaine )

Rank	Target	Score	Validated	KEGG
1	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.958448	1	1
2	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.957783	1	1
3	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.954119	1	1
4	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.931988	1	1
5	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.929403	1	1
6	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.916311	1	1
7	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.881059	0	0
8	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.798135	0	0
9	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.749136	0	0
10	hsa6324 ( sodium voltage-gated channel beta subunit 1 )	0.736682	0	0

D00735 : Dyclonine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00735 ( Dyclonine hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.793749
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.778477
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.735858
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.705718
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.702767
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.656499
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.61861
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.613417
9	hsa6530 ( solute carrier family 6 member 2 )	0.602637
10	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.597125

D00738 : Mepivacaine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00738 ( Mepivacaine hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.827025
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.788697
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.746124
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.71464
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.699678
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.67499
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.649859
8	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.623409
9	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.598822
10	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.591468

D00739 : Pramoxine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00739 ( Pramoxine hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.807393
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.775277
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.719747
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.719469
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.694139
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.664573
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.634865
8	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.610832
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.604227
10	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.595692

D00740 : Procaine hydrochloride (Found 4 out of 45 validated targets)

Top-10 predicted interaction for: D00740 ( Procaine hydrochloride )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.783337	1	0	1
2	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.763651	1	0	1
3	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.721423	0	0	0
4	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.693489	0	0	0
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.657757	0	0	0
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.639533	0	0	0
7	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.625766	0	0	0
8	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.619775	1	0	1
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.618011	1	1	1
10	hsa6530 ( solute carrier family 6 member 2 )	0.574459	0	0	0

D00741 : Tetracaine hydrochloride (Found 1 out of 3 validated targets)

Top-10 predicted interaction for: D00741 ( Tetracaine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.804028	0	0
2	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.781855	0	0
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.737496	0	0
4	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.718388	0	0
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.687548	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.664202	0	0
7	hsa6261 ( ryanodine receptor 1 )	0.612449	1	1
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.612075	0	0
9	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.598873	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.593462	0	0

D00759 : Cisatracurium besylate (Found 1 out of 4 validated targets)

Top-10 predicted interaction for: D00759 ( Cisatracurium besylate )

Rank	Target	Score	Validated	KEGG
1	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.959511	0	0
2	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.950053	0	0
3	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.948675	0	0
4	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.943746	0	0
5	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.942496	0	0
6	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.939167	0	0
7	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.935586	0	0
8	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.933353	0	0
9	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.924952	1	1
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.834391	0	0

D00760 : Doxacurium chloride (Found 1 out of 4 validated targets)

Top-10 predicted interaction for: D00760 ( Doxacurium chloride )

Rank	Target	Score	Validated	KEGG
1	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.957548	0	0
2	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.947639	0	0
3	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.945814	0	0
4	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.941801	0	0
5	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.940765	0	0
6	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.936358	0	0
7	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.932015	0	0
8	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.929745	0	0
9	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.920809	1	1
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.831677	0	0

D00761 : Metocurine iodide (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00761 ( Metocurine iodide )

Rank	Target	Score
1	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.959814
2	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.950538
3	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.949049
4	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.945095
5	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.944211
6	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.939807
7	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.935604
8	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.933747
9	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.925246
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.815609

D00765 : Rocuronium bromide (Found 2 out of 5 validated targets)

Top-10 predicted interaction for: D00765 ( Rocuronium bromide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.960688	0	0	0
2	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.953745	0	0	0
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.95119	0	0	0
4	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.948982	0	0	0
5	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.944933	0	0	0
6	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.940245	0	0	0
7	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.934451	0	0	0
8	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.93274	0	0	0
9	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.925158	1	1	0
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.828001	1	0	1

D00771 : Chlorzoxazone (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00771 ( Chlorzoxazone )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.84406
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.781412
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.775804
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.701814
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.699529
6	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.695975
7	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.695157
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.675275
9	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.674295
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.672562

D00775 : Riluzole (Found 2 out of 27 validated targets)

Top-10 predicted interaction for: D00775 ( Riluzole )

Rank	Target	Score	Validated	Matador
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.842849	0	0
2	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.809645	0	0
3	hsa2898 ( glutamate ionotropic receptor kainate type subunit 2 )	0.772445	1	1
4	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.760157	0	0
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.758562	0	0
6	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.724128	0	0
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.685926	1	1
8	hsa40 ( acid sensing ion channel subunit 2 )	0.683321	0	0
9	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.666691	0	0
10	hsa41 ( acid sensing ion channel subunit 1 )	0.652452	0	0

D00779 : Biperiden (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00779 ( Biperiden )

Rank	Target	Score
1	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.954187
2	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.944625
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.943493
4	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.941248
5	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.936846
6	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.93116
7	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.924698
8	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.92315
9	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.914489
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.835207

D00791 : Fluphenazine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00791 ( Fluphenazine hydrochloride )

Rank	Target	Score
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.978653
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.951277
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.90634
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.859905
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.793705
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.74299
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.735665
8	hsa6530 ( solute carrier family 6 member 2 )	0.720767
9	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.70923
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.683927

D00798 : Thioridazine hydrochloride (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00798 ( Thioridazine hydrochloride )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.920305
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.908394
3	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.860879
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.829509
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.822208
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.808895
7	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.762257
8	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.740728
9	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.737041
10	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.719126

D00799 : Trifluoperazine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00799 ( Trifluoperazine hydrochloride )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.982761
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.958268
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.916579
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.86601
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.792444
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.755998
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.74945
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.714902
9	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.712619
10	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.701736

D00809 : Amitriptyline hydrochloride (Found 2 out of 7 validated targets)

Top-10 predicted interaction for: D00809 ( Amitriptyline hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.949185	0	0	0
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.875663	0	0	0
3	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.858999	0	0	0
4	hsa6530 ( solute carrier family 6 member 2 )	0.792404	1	1	1
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.777573	0	0	0
6	hsa6532 ( solute carrier family 6 member 4 )	0.766722	1	1	1
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.740892	0	0	0
8	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.721068	0	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.71017	0	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.704018	0	0	0

D00812 : Desipramine hydrochloride (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00812 ( Desipramine hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.973907	0	0	0	0
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.940062	0	0	0	0
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.867325	0	0	0	0
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.857094	0	0	0	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.839121	1	1	1	1
6	hsa6532 ( solute carrier family 6 member 4 )	0.814438	1	1	1	0
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.788884	0	0	0	0
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.723139	0	0	0	0
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.721658	0	0	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.702205	0	0	0	0

D00816 : Nortriptyline hydrochloride (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D00816 ( Nortriptyline hydrochloride )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.974583	0	0	0	0
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.939233	0	0	0	0
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.868372	0	0	0	0
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.853209	0	0	0	0
5	hsa6530 ( solute carrier family 6 member 2 )	0.841677	1	1	1	1
6	hsa6532 ( solute carrier family 6 member 4 )	0.817073	1	1	1	0
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.787672	0	0	0	0
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.732791	0	0	0	0
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.721517	0	0	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.707314	0	0	0	0

D00823 : Fluoxetine hydrochloride (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D00823 ( Fluoxetine hydrochloride )

Rank	Target	Score
1	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.846993
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.78618
3	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.767154
4	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.736924
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.711774
6	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.709619
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.708133
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.686628
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.659752
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.657681

D00831 : Mefloquine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00831 ( Mefloquine hydrochloride )

Rank	Target	Score
1	hsa3753 ( potassium voltage-gated channel subfamily E regulatory subunit 1 )	0.894264
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.825492
3	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.809134
4	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.788985
5	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.784658
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.759675
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.749187
8	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.731028
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.714004
10	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.709912

D00960 : Anastrozole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00960 ( Anastrozole )

Rank	Target	Score
1	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.94035
2	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.892658
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.872452
4	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.843504
5	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.842252
6	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.83536
7	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.806675
8	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.804744
9	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.78077
10	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.779672

D00963 : Exemestane (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00963 ( Exemestane )

Rank	Target	Score
1	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.954587
2	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.915522
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.897479
4	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.874833
5	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.87229
6	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.870093
7	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.841568
8	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.827425
9	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.822859
10	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.821528

D00964 : Letrozole (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D00964 ( Letrozole )

Rank	Target	Score
1	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.943693
2	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.901119
3	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.880726
4	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.854615
5	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.853048
6	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.848794
7	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.818847
8	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.809524
9	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.799175
10	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.798414

D01071 : Hexobarbital (Found 10 out of 17 validated targets)

Top-10 predicted interaction for: D01071 ( Hexobarbital )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.945705	1	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.941448	1	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.941305	1	1	1
4	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.938785	1	1	1
5	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.938623	1	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.839957	1	1	0
7	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.839201	1	1	0
8	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.839112	1	1	0
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.814228	1	1	0
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.809143	1	1	0

D01108 : Magnesium sulfate (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D01108 ( Magnesium sulfate )

Rank	Target	Score	Validated	DrugBank
1	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.957015	1	1
2	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.956484	0	0
3	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.953831	0	0
4	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.931318	1	1
5	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.926095	0	0
6	hsa782 ( calcium voltage-gated channel auxiliary subunit beta 1 )	0.924671	1	1
7	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.912074	0	0
8	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.863027	0	0
9	hsa9254 ( calcium voltage-gated channel auxiliary subunit alpha2delta 2 )	0.851596	0	0
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.845025	0	0

D01111 : Nateglinide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01111 ( Nateglinide )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.934868	0	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.901478	1	1	1
3	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.765247	0	0	0
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.743976	0	0	0
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.738995	0	0	0
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.736527	0	0	0
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.710689	0	0	0
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.690783	0	0	0
9	hsa6530 ( solute carrier family 6 member 2 )	0.674241	0	0	0
10	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.655584	0	0	0

D01118 : Profenamine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01118 ( Profenamine hydrochloride )

Rank	Target	Score
1	hsa6532 ( solute carrier family 6 member 4 )	0.862673
2	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.833872
3	hsa6530 ( solute carrier family 6 member 2 )	0.824069
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.806181
5	hsa116444 ( glutamate ionotropic receptor NMDA type subunit 3B )	0.772817
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.727325
7	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.724894
8	hsa2904 ( glutamate ionotropic receptor NMDA type subunit 2B )	0.718873
9	hsa2902 ( glutamate ionotropic receptor NMDA type subunit 1 )	0.717833
10	hsa2906 ( glutamate ionotropic receptor NMDA type subunit 2D )	0.7154

D01242 : Promethazine teoclate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01242 ( Promethazine teoclate )

Rank	Target	Score
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.973511
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.941491
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.874147
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.852634
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.785877
6	hsa6530 ( solute carrier family 6 member 2 )	0.78422
7	hsa6532 ( solute carrier family 6 member 4 )	0.76139
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.727294
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.718583
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.699648

D01243 : Prilocaine hydrochloride (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D01243 ( Prilocaine hydrochloride )

Rank	Target	Score	Validated	KEGG
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.806308	0	0
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.793478	1	1
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.722403	0	0
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.7201	0	0
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.712138	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.656668	0	0
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.634912	0	0
8	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.608527	0	0
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.602038	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.589429	0	0

D01253 : Clobazam (Found 10 out of 13 validated targets)

Top-10 predicted interaction for: D01253 ( Clobazam )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.960533	1	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.957518	1	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.9574	1	1	1
4	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.955772	1	1	1
5	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.955417	1	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.890938	1	1	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.887659	1	1	1
8	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.887461	1	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.875184	1	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.874317	1	1	1

D01256 : Cyclothiazide (Found 5 out of 33 validated targets)

Top-10 predicted interaction for: D01256 ( Cyclothiazide )

Rank	Target	Score	Validated	Matador
1	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.855	1	1
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.753835	0	0
3	hsa2893 ( glutamate ionotropic receptor AMPA type subunit 4 )	0.750694	1	1
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.750639	0	0
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.749077	1	1
6	hsa2892 ( glutamate ionotropic receptor AMPA type subunit 3 )	0.745722	1	1
7	hsa2897 ( glutamate ionotropic receptor kainate type subunit 1 )	0.723153	1	1
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.699386	0	0
9	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.698206	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.67522	0	0

D01275 : Doxorubicin hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01275 ( Doxorubicin hydrochloride )

Rank	Target	Score
1	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.876178
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.860084
3	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.744454
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.735823
5	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.731117
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.694957
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.684993
8	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.663882
9	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.662928
10	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.662481

D01287 : Levobupivacaine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01287 ( Levobupivacaine hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.833434
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.782593
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.742168
4	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.699075
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.685949
6	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.680661
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.650156
8	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.628585
9	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.60863
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.598817

D01295 : Cinnarizine (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01295 ( Cinnarizine )

Rank	Target	Score
1	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.777855
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.706341
3	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.599619
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.551191
5	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.540442
6	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.533945
7	hsa56659 ( potassium two pore domain channel subfamily K member 13 )	0.531939
8	hsa6530 ( solute carrier family 6 member 2 )	0.529872
9	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.504922
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.494948

D01350 : Streptomycin sulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01350 ( Streptomycin sulfate )

Rank	Target	Score
1	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.899529
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.87403
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.711154
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.699723
5	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.69907
6	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.688411
7	hsa5026 ( purinergic receptor P2X 5 )	0.6855
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.685284
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.68273
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.652523

D01448 : Trifluoperazine maleate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01448 ( Trifluoperazine maleate )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.983056
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.95455
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.897478
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.866864
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.772547
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.756528
7	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.735162
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.716196
9	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.70892
10	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.705391

D01450 : Bupivacaine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01450 ( Bupivacaine hydrochloride )

Rank	Target	Score
1	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.767412
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.720418
3	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.715948
4	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.649784
5	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.646798
6	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.64301
7	hsa83795 ( potassium two pore domain channel subfamily K member 16 )	0.630563
8	hsa9424 ( potassium two pore domain channel subfamily K member 6 )	0.624529
9	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.624405
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.623561

D01453 : Caffeine hydrate (Found 5 out of 43 validated targets)

Top-10 predicted interaction for: D01453 ( Caffeine hydrate )

Rank	Target	Score	Validated	Matador
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.782775	0	0
2	hsa5026 ( purinergic receptor P2X 5 )	0.780182	1	1
3	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.773265	0	0
4	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.769888	0	0
5	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.757015	0	0
6	hsa5024 ( purinergic receptor P2X 3 )	0.731373	1	1
7	hsa5027 ( purinergic receptor P2X 7 )	0.725032	1	1
8	hsa5025 ( purinergic receptor P2X 4 )	0.722815	1	1
9	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.720695	0	0
10	hsa9127 ( purinergic receptor P2X 6 )	0.718232	1	1

D01575 : Dequalinium chloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01575 ( Dequalinium chloride )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.980274
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.978644
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.898903
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.88228
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.781868
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.742346
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.741578
8	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.72279
9	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.699997
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.671344

D01599 : Gliclazide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01599 ( Gliclazide )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.966725	0	0	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.861409	1	1	1	1
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.761716	0	0	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.748058	0	0	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.706161	0	0	0	0
6	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.687614	0	0	0	0
7	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.682071	0	0	0	0
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.669898	0	0	0	0
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.66377	0	0	0	0
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.65649	0	0	0	0

D01603 : Bethanidine sulfate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01603 ( Bethanidine sulfate )

Rank	Target	Score	Validated	DrugBank
1	hsa6532 ( solute carrier family 6 member 4 )	0.963767	0	0
2	hsa6531 ( solute carrier family 6 member 3 )	0.950157	0	0
3	hsa11254 ( solute carrier family 6 member 14 )	0.837355	0	0
4	hsa6534 ( solute carrier family 6 member 7 )	0.815399	0	0
5	hsa6529 ( solute carrier family 6 member 1 )	0.790653	0	0
6	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.721485	0	0
7	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.708761	0	0
8	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.702945	0	0
9	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.687125	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.68669	1	1

D01712 : Theophylline sodium acetate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01712 ( Theophylline sodium acetate )

Rank	Target	Score
1	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.81049
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.791007
3	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.790655
4	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.764411
5	hsa5026 ( purinergic receptor P2X 5 )	0.763999
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.721566
7	hsa5024 ( purinergic receptor P2X 3 )	0.713421
8	hsa5027 ( purinergic receptor P2X 7 )	0.709172
9	hsa5025 ( purinergic receptor P2X 4 )	0.706957
10	hsa9127 ( purinergic receptor P2X 6 )	0.700773

D01768 : Benoxinate hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01768 ( Benoxinate hydrochloride )

Rank	Target	Score
1	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.989475
2	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.972947
3	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.972755
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.96982
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.956403
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.954471
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.94541
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.915608
9	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.819262
10	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.755298

D01799 : Glyclopyramide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01799 ( Glyclopyramide )

Rank	Target	Score	Validated	KEGG
1	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.968931	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.86585	1	1
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.769687	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.749699	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.702786	0	0
6	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.686515	0	0
7	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.68442	0	0
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.666781	0	0
9	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.655624	0	0
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.648475	0	0

D01828 : Amlexanox (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D01828 ( Amlexanox )

Rank	Target	Score
1	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.942238
2	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.895954
3	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.842069
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.772094
5	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.747203
6	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.690611
7	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.683928
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.677819
9	hsa6530 ( solute carrier family 6 member 2 )	0.669366
10	hsa6261 ( ryanodine receptor 1 )	0.66215

D01854 : Mitiglinide calcium hydrate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D01854 ( Mitiglinide calcium hydrate )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.95012	0	0	0
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.802316	1	1	1
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.789619	0	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.784346	0	0	0
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.752028	0	0	0
6	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.72375	0	0	0
7	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.692174	0	0	0
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.691132	0	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.667667	0	0	0
10	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.660042	0	0	0

D01969 : Gallopamil hydrochloride (Found 7 out of 25 validated targets)

Top-10 predicted interaction for: D01969 ( Gallopamil hydrochloride )

Rank	Target	Score	Validated	KEGG	Matador
1	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.980737	1	1	1
2	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.96897	1	1	1
3	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.961056	1	0	1
4	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.900811	1	0	1
5	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.881568	1	0	1
6	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.873132	0	0	0
7	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.871483	1	0	1
8	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.857075	1	0	1
9	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.855118	0	0	0
10	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.848788	0	0	0

D02041 : Tropisetron hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02041 ( Tropisetron hydrochloride )

Rank	Target	Score
1	hsa2743 ( glycine receptor beta )	0.830159
2	hsa6530 ( solute carrier family 6 member 2 )	0.808539
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.796537
4	hsa6532 ( solute carrier family 6 member 4 )	0.762482
5	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.750934
6	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.729667
7	hsa6531 ( solute carrier family 6 member 3 )	0.71108
8	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.686064
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.682252
10	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.680243

D02086 : Lidocaine hydrochloride (Found 1 out of 9 validated targets)

Top-10 predicted interaction for: D02086 ( Lidocaine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.804087	0	0
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.796199	1	1
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.733318	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.713143	0	0
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.710913	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.656645	0	0
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.629203	0	0
8	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.605101	0	0
9	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.597854	0	0
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.597375	0	0

D02087 : Moricizine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02087 ( Moricizine hydrochloride )

Rank	Target	Score
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.962502
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.934381
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.841845
4	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.801278
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.723752
6	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.720255
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.712393
8	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.701924
9	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.681543
10	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.662814

D02088 : Tocainide hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02088 ( Tocainide hydrochloride )

Rank	Target	Score
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.976725
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.952255
3	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.819595
4	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.77906
5	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.737144
6	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.734838
7	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.69082
8	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.66784
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.658988
10	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.610291

D02092 : Cisapride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02092 ( Cisapride )

Rank	Target	Score
1	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.821594
2	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.783067
3	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.764562
4	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.751978
5	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.746167
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.716619
7	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.712277
8	hsa90134 ( potassium voltage-gated channel subfamily H member 7 )	0.70633
9	hsa81033 ( potassium voltage-gated channel subfamily H member 6 )	0.702034
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.701642

D02098 : Proparacaine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02098 ( Proparacaine hydrochloride )

Rank	Target	Score
1	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.940591
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.79964
3	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.760404
4	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.749662
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.716523
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.6548
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.653768
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.649043
9	hsa6261 ( ryanodine receptor 1 )	0.624095
10	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.622894

D02101 : Codeine phosphate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02101 ( Codeine phosphate )

Rank	Target	Score
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.973667
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.896246
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.861632
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.795272
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.78884
6	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.776207
7	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.723109
8	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.720567
9	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.683434
10	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.669454

D02163 : Fluphenazine maleate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02163 ( Fluphenazine maleate )

Rank	Target	Score
1	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.979872
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.954155
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.905376
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.861858
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.781542
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.729873
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.727423
8	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.711847
9	hsa6530 ( solute carrier family 6 member 2 )	0.71123
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.700337

D02173 : Galantamine hydrobromide (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D02173 ( Galantamine hydrobromide )

Rank	Target	Score	Validated	DrugBank
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.967225	1	1
2	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.902692	0	0
3	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.887257	1	1
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.793064	0	0
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.783157	1	1
6	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.761592	0	0
7	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.75922	0	0
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.717255	1	1
9	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.701887	0	0
10	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.68649	0	0

D02204 : Hexamethonium bromide (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02204 ( Hexamethonium bromide )

Rank	Target	Score	Validated	KEGG
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.964985	1	1
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.86814	0	0
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.826631	0	0
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.764839	0	0
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.748947	0	0
6	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.739323	0	0
7	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.731913	0	0
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.683893	0	0
9	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.664328	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.646818	0	0

D02207 : Tubocurarine chloride (Found 3 out of 4 validated targets)

Top-10 predicted interaction for: D02207 ( Tubocurarine chloride )

Rank	Target	Score	Validated	KEGG	DrugBank
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.933062	0	0	0
2	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.861009	0	0	0
3	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.799004	1	1	0
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.759068	0	0	0
5	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.755539	0	0	0
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.749879	1	0	1
7	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.74847	0	0	0
8	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.730978	0	0	0
9	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.673781	0	0	0
10	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.671301	1	1	0

D02234 : Cyproheptadine hydrochloride (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02234 ( Cyproheptadine hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.978851	0	0
2	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.943485	0	0
3	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.863447	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.851549	0	0
5	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.795508	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.775744	0	0
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.74614	0	0
8	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.732934	0	0
9	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.711512	0	0
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.708689	1	1

D02237 : Guanethidine sulfate (Found 2 out of 8 validated targets)

Top-10 predicted interaction for: D02237 ( Guanethidine sulfate )

Rank	Target	Score	Validated	Matador
1	hsa6532 ( solute carrier family 6 member 4 )	0.966065	0	0
2	hsa6531 ( solute carrier family 6 member 3 )	0.956277	0	0
3	hsa11254 ( solute carrier family 6 member 14 )	0.839532	0	0
4	hsa6534 ( solute carrier family 6 member 7 )	0.816616	0	0
5	hsa6529 ( solute carrier family 6 member 1 )	0.796066	0	0
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.724076	0	0
7	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.720203	0	0
8	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.715486	1	1
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.711712	0	0
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.709177	1	1

D02253 : Pentobarbital calcium (Found 9 out of 27 validated targets)

Top-10 predicted interaction for: D02253 ( Pentobarbital calcium )

Rank	Target	Score	Validated	KEGG	DrugBank	Matador
1	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.912837	1	1	1	1
2	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.912577	1	1	1	1
3	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.910957	1	1	1	1
4	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.880356	1	1	1	1
5	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.877095	1	1	1	1
6	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.875712	1	0	0	1
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.875237	1	1	1	1
8	hsa2562 ( gamma-aminobutyric acid type A receptor beta3 subunit )	0.871086	1	1	1	1
9	hsa2560 ( gamma-aminobutyric acid type A receptor beta1 subunit )	0.862823	1	1	1	1
10	hsa2741 ( glycine receptor alpha 1 )	0.813644	0	0	0	0

D02261 : Quinine hydrochloride hydrate (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D02261 ( Quinine hydrochloride hydrate )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.939029
2	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.913462
3	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.858608
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.852635
5	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.835225
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.826376
7	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.825745
8	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.799971
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.79029
10	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.763733

D02262 : Quinine sulfate (Found 0 out of 1 validated targets)

Top-10 predicted interaction for: D02262 ( Quinine sulfate )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.930478
2	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.899897
3	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.855096
4	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.848163
5	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.823375
6	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.815469
7	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.812527
8	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.790274
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.761406
10	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.759552

D02272 : Quinidine sulfate (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D02272 ( Quinidine sulfate )

Rank	Target	Score	Validated	DrugBank
1	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.898009	0	0
2	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.895848	0	0
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.88947	1	1
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.828815	0	0
5	hsa3737 ( potassium voltage-gated channel subfamily A member 2 )	0.787992	0	0
6	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.783109	0	0
7	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.747179	0	0
8	hsa3746 ( potassium voltage-gated channel subfamily C member 1 )	0.739358	0	0
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.732783	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.69611	0	0

D02347 : Dantrolene (Found 2 out of 2 validated targets)

Top-10 predicted interaction for: D02347 ( Dantrolene )

Rank	Target	Score	Validated	KEGG
1	hsa6263 ( ryanodine receptor 3 )	0.970142	1	1
2	hsa6262 ( ryanodine receptor 2 )	0.966156	1	1
3	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.84462	0	0
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.823606	0	0
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.802144	0	0
6	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.699873	0	0
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.697864	0	0
8	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.680453	0	0
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.666607	0	0
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.664413	0	0

D02356 : Verapamil (Found 1 out of 14 validated targets)

Top-10 predicted interaction for: D02356 ( Verapamil )

Rank	Target	Score	Validated	DrugBank
1	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.75149	1	1
2	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.539372	0	0
3	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.432318	0	0
4	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.403761	0	0
5	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.376561	0	0
6	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.363173	0	0
7	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.359564	0	0
8	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.353044	0	0
9	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.332447	0	0
10	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.324746	0	0

D02360 : Sertraline (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02360 ( Sertraline )

Rank	Target	Score	Validated	DrugBank
1	hsa6530 ( solute carrier family 6 member 2 )	0.976258	0	0
2	hsa6531 ( solute carrier family 6 member 3 )	0.93186	1	1
3	hsa11254 ( solute carrier family 6 member 14 )	0.840278	0	0
4	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.820671	0	0
5	hsa6534 ( solute carrier family 6 member 7 )	0.816478	0	0
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.801074	0	0
7	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.793629	0	0
8	hsa6529 ( solute carrier family 6 member 1 )	0.787438	0	0
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.731077	0	0
10	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.723385	0	0

D02362 : Paroxetine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D02362 ( Paroxetine )

Rank	Target	Score	Validated	DrugBank
1	hsa6530 ( solute carrier family 6 member 2 )	0.975019	1	1
2	hsa6531 ( solute carrier family 6 member 3 )	0.933407	0	0
3	hsa11254 ( solute carrier family 6 member 14 )	0.841437	0	0
4	hsa6534 ( solute carrier family 6 member 7 )	0.816929	0	0
5	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.811746	0	0
6	hsa6529 ( solute carrier family 6 member 1 )	0.794954	0	0
7	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.74071	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.73808	0	0
9	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.737271	0	0
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.724032	0	0

D02409 : Caffeine and sodium benzoate (Found 4 out of 43 validated targets)

Top-10 predicted interaction for: D02409 ( Caffeine and sodium benzoate )

Rank	Target	Score	Validated	Matador
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.800948	0	0
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.7775	0	0
3	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.765553	0	0
4	hsa6833 ( ATP binding cassette subfamily C member 8 )	0.761103	0	0
5	hsa5026 ( purinergic receptor P2X 5 )	0.75045	1	1
6	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.720051	0	0
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.711	0	0
8	hsa5024 ( purinergic receptor P2X 3 )	0.699703	1	1
9	hsa5025 ( purinergic receptor P2X 4 )	0.694343	1	1
10	hsa5027 ( purinergic receptor P2X 7 )	0.694293	1	1

D02461 : Penicillin G procaine (Found 0 out of 41 validated targets)

Top-10 predicted interaction for: D02461 ( Penicillin G procaine )

Rank	Target	Score
1	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.875665
2	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.874401
3	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.873988
4	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.830158
5	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.825192
6	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.824099
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.822649
8	hsa2562 ( gamma-aminobutyric acid type A receptor beta3 subunit )	0.815959
9	hsa2560 ( gamma-aminobutyric acid type A receptor beta1 subunit )	0.806097
10	hsa3736 ( potassium voltage-gated channel subfamily A member 1 )	0.781326

D02485 : Halofantrine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02485 ( Halofantrine hydrochloride )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.822651
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.817902
3	hsa27133 ( potassium voltage-gated channel subfamily H member 5 )	0.81497
4	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.798274
5	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.764879
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.760597
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.741214
8	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.721844
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.719366
10	hsa3776 ( potassium two pore domain channel subfamily K member 2 )	0.717417

D02546 : Kainic acid hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02546 ( Kainic acid hydrate )

Rank	Target	Score
1	hsa2891 ( glutamate ionotropic receptor AMPA type subunit 2 )	0.891716
2	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.886708
3	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.797313
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.794021
5	hsa2892 ( glutamate ionotropic receptor AMPA type subunit 3 )	0.792478
6	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.777848
7	hsa2893 ( glutamate ionotropic receptor AMPA type subunit 4 )	0.760024
8	hsa2895 ( glutamate ionotropic receptor delta type subunit 2 )	0.752219
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.741266
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.740116

D02566 : Maprotiline (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02566 ( Maprotiline )

Rank	Target	Score
1	hsa6532 ( solute carrier family 6 member 4 )	0.97204
2	hsa6531 ( solute carrier family 6 member 3 )	0.948695
3	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.873826
4	hsa11254 ( solute carrier family 6 member 14 )	0.843816
5	hsa6534 ( solute carrier family 6 member 7 )	0.822314
6	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.800316
7	hsa6529 ( solute carrier family 6 member 1 )	0.793504
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.722784
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.720986
10	hsa116443 ( glutamate ionotropic receptor NMDA type subunit 3A )	0.713335

D02630 : Penfluridol (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D02630 ( Penfluridol )

Rank	Target	Score
1	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.861231
2	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.848778
3	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.828596
4	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.828593
5	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.828249
6	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.825135
7	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.814836
8	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.811302
9	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.798379
10	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.791662

D02914 : Amlodipine maleate (Found 5 out of 5 validated targets)

Top-10 predicted interaction for: D02914 ( Amlodipine maleate )

Rank	Target	Score	Validated	DrugBank	Matador
1	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.939844	1	0	1
2	hsa777 ( calcium voltage-gated channel subunit alpha1 E )	0.931716	0	0	0
3	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.931626	0	0	0
4	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.926616	1	1	1
5	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.903972	1	1	0
6	hsa8912 ( calcium voltage-gated channel subunit alpha1 H )	0.901485	0	0	0
7	hsa8911 ( calcium voltage-gated channel subunit alpha1 I )	0.894562	0	0	0
8	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.88934	0	0	0
9	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.884253	1	1	0
10	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.865196	1	1	0

D03037 : Azimilide dihydrochloride (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D03037 ( Azimilide dihydrochloride )

Rank	Target	Score	Validated	KEGG
1	hsa3753 ( potassium voltage-gated channel subfamily E regulatory subunit 1 )	0.890028	0	0
2	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.788641	0	0
3	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.771313	0	0
4	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.764018	0	0
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.751877	0	0
6	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.751169	0	0
7	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.742552	1	1
8	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.72869	0	0
9	hsa3778 ( potassium calcium-activated channel subfamily M alpha 1 )	0.699004	0	0
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.683636	0	0

D03180 : Butabarbital (Found 10 out of 17 validated targets)

Top-10 predicted interaction for: D03180 ( Butabarbital )

Rank	Target	Score	Validated	DrugBank
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.949676	1	1
2	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.945553	1	1
3	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.945505	1	1
4	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.943273	1	1
5	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.943023	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.849248	1	1
7	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.848019	1	1
8	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.84781	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.823154	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.81872	1	1

D03274 : Chlorpromazine hibenzate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D03274 ( Chlorpromazine hibenzate )

Rank	Target	Score	Validated	DrugBank
1	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.946937	0	0
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.878562	0	0
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.871285	0	0
4	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.795827	1	1
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.784552	0	0
6	hsa6530 ( solute carrier family 6 member 2 )	0.748401	0	0
7	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.72507	0	0
8	hsa6532 ( solute carrier family 6 member 4 )	0.709512	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.709336	0	0
10	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.705087	0	0

D03365 : Nicotine (Found 3 out of 3 validated targets)

Top-10 predicted interaction for: D03365 ( Nicotine )

Rank	Target	Score	Validated	DrugBank
1	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.965774	1	1
2	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.959932	1	1
3	hsa1139 ( cholinergic receptor nicotinic alpha 7 subunit )	0.959924	1	1
4	hsa1134 ( cholinergic receptor nicotinic alpha 1 subunit )	0.95599	0	0
5	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.834253	0	0
6	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.830583	0	0
7	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.824231	0	0
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.785364	0	0
9	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.756282	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.723605	0	0

D03450 : Cetiedil citrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03450 ( Cetiedil citrate )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.91924
2	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.9088
3	hsa1080 ( cystic fibrosis transmembrane conductance regulator )	0.900792
4	hsa6261 ( ryanodine receptor 1 )	0.885705
5	hsa6262 ( ryanodine receptor 2 )	0.874858
6	hsa6263 ( ryanodine receptor 3 )	0.874648
7	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.850581
8	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.807472
9	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.785195
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.743173

D03580 : Codeine sulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03580 ( Codeine sulfate )

Rank	Target	Score
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.965854
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.878152
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.836421
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.798229
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.794638
6	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.761244
7	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.7284
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.696509
9	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.663496
10	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.661896

D03742 : Dextromethorphan (Found 4 out of 10 validated targets)

Top-10 predicted interaction for: D03742 ( Dextromethorphan )

Rank	Target	Score	Validated	DrugBank
1	hsa6530 ( solute carrier family 6 member 2 )	0.920092	1	1
2	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.883195	1	1
3	hsa8973 ( cholinergic receptor nicotinic alpha 6 subunit )	0.877707	0	0
4	hsa1136 ( cholinergic receptor nicotinic alpha 3 subunit )	0.85246	1	1
5	hsa57053 ( cholinergic receptor nicotinic alpha 10 subunit )	0.842489	0	0
6	hsa55584 ( cholinergic receptor nicotinic alpha 9 subunit )	0.839067	0	0
7	hsa1137 ( cholinergic receptor nicotinic alpha 4 subunit )	0.829764	1	1
8	hsa6531 ( solute carrier family 6 member 3 )	0.818666	0	0
9	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.817819	0	0
10	hsa1138 ( cholinergic receptor nicotinic alpha 5 subunit )	0.812881	0	0

D03826 : Physostigmine sulfate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03826 ( Physostigmine sulfate )

Rank	Target	Score
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.95576
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.867027
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.831524
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.812422
5	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.795726
6	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.74706
7	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.731739
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.682467
9	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.674415
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.673544

D03830 : Diltiazem malate (Found 1 out of 2 validated targets)

Top-10 predicted interaction for: D03830 ( Diltiazem malate )

Rank	Target	Score	Validated	KEGG
1	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.939403	0	0
2	hsa3739 ( potassium voltage-gated channel subfamily A member 4 )	0.905772	0	0
3	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.903247	1	1
4	hsa773 ( calcium voltage-gated channel subunit alpha1 A )	0.894649	0	0
5	hsa3744 ( potassium voltage-gated channel subfamily A member 10 )	0.868293	0	0
6	hsa3747 ( potassium voltage-gated channel subfamily C member 2 )	0.839862	0	0
7	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.801023	0	0
8	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.797138	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.790667	0	0
10	hsa2890 ( glutamate ionotropic receptor AMPA type subunit 1 )	0.712744	0	0

D03878 : Dizocilpine maleate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D03878 ( Dizocilpine maleate )

Rank	Target	Score
1	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.791873
2	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.788585
3	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.782504
4	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.77592
5	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.74582
6	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.733026
7	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.726698
8	hsa6532 ( solute carrier family 6 member 4 )	0.706267
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.68819
10	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.679275

D03991 : Encainide hydrochloride (Found 2 out of 10 validated targets)

Top-10 predicted interaction for: D03991 ( Encainide hydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.967333	1	1
2	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.939202	0	0
3	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.82242	0	0
4	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.817959	0	0
5	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.736718	1	1
6	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.715228	0	0
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.676301	0	0
8	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.674164	0	0
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.637679	0	0
10	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.633898	0	0

D04034 : Chlorpromazine phenolphthalinate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D04034 ( Chlorpromazine phenolphthalinate )

Rank	Target	Score	Validated	DrugBank
1	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.943099	0	0
2	hsa3783 ( potassium calcium-activated channel subfamily N member 4 )	0.878738	0	0
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.866495	0	0
4	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.799578	1	1
5	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.774782	0	0
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.719115	0	0
7	hsa3784 ( potassium voltage-gated channel subfamily Q member 1 )	0.704091	0	0
8	hsa6530 ( solute carrier family 6 member 2 )	0.70321	0	0
9	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.702828	0	0
10	hsa9132 ( potassium voltage-gated channel subfamily Q member 4 )	0.681519	0	0

D04048 : Ropivacaine hydrochloride (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D04048 ( Ropivacaine hydrochloride )

Rank	Target	Score
1	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.83716
2	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.785035
3	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.744544
4	hsa8913 ( calcium voltage-gated channel subunit alpha1 G )	0.707172
5	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.690174
6	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.676231
7	hsa3743 ( potassium voltage-gated channel subfamily A member 7 )	0.658867
8	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.625175
9	hsa54207 ( potassium two pore domain channel subfamily K member 10 )	0.616226
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.595702

D04370 : Granisetron (Found 4 out of 4 validated targets)

Top-10 predicted interaction for: D04370 ( Granisetron )

Rank	Target	Score	Validated	KEGG
1	hsa285242 ( 5-hydroxytryptamine receptor 3E )	0.965323	1	1
2	hsa9177 ( 5-hydroxytryptamine receptor 3B )	0.957084	1	1
3	hsa170572 ( 5-hydroxytryptamine receptor 3C )	0.917119	1	1
4	hsa200909 ( 5-hydroxytryptamine receptor 3D )	0.913835	1	1
5	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.79325	0	0
6	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.74293	0	0
7	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.728869	0	0
8	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.717164	0	0
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.71322	0	0
10	hsa6530 ( solute carrier family 6 member 2 )	0.713121	0	0

D04790 : Lubiprostone (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D04790 ( Lubiprostone )

Rank	Target	Score
1	hsa6530 ( solute carrier family 6 member 2 )	0.824492
2	hsa6532 ( solute carrier family 6 member 4 )	0.754065
3	hsa3757 ( potassium voltage-gated channel subfamily H member 2 )	0.749136
4	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.744668
5	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.741967
6	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.729284
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.719379
8	hsa6531 ( solute carrier family 6 member 3 )	0.705042
9	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.701347
10	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.698783

D04985 : Methohexital (Found 10 out of 14 validated targets)

Top-10 predicted interaction for: D04985 ( Methohexital )

Rank	Target	Score	Validated	Matador
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.950428	1	1
2	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.946423	1	1
3	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.946388	1	1
4	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.943944	1	1
5	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.943768	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.846415	1	1
7	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.846075	1	1
8	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.845683	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.819182	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.814265	1	1

D04999 : Methylphenidate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D04999 ( Methylphenidate )

Rank	Target	Score	Validated	DrugBank
1	hsa6532 ( solute carrier family 6 member 4 )	0.967676	1	1
2	hsa11254 ( solute carrier family 6 member 14 )	0.856566	0	0
3	hsa6529 ( solute carrier family 6 member 1 )	0.834828	0	0
4	hsa6534 ( solute carrier family 6 member 7 )	0.832994	0	0
5	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.756164	0	0
6	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.745239	0	0
7	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.734074	0	0
8	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.715147	0	0
9	hsa1135 ( cholinergic receptor nicotinic alpha 2 subunit )	0.702249	0	0
10	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.698421	0	0

D05024 : Mibefradil dihydrochloride (Found 5 out of 5 validated targets)

Top-10 predicted interaction for: D05024 ( Mibefradil dihydrochloride )

Rank	Target	Score	Validated	Matador
1	hsa775 ( calcium voltage-gated channel subunit alpha1 C )	0.978078	1	1
2	hsa779 ( calcium voltage-gated channel subunit alpha1 S )	0.975366	0	0
3	hsa778 ( calcium voltage-gated channel subunit alpha1 F )	0.973281	1	1
4	hsa776 ( calcium voltage-gated channel subunit alpha1 D )	0.963014	1	1
5	hsa786 ( calcium voltage-gated channel auxiliary subunit gamma 1 )	0.89641	1	1
6	hsa783 ( calcium voltage-gated channel auxiliary subunit beta 2 )	0.888283	1	1
7	hsa93589 ( calcium voltage-gated channel auxiliary subunit alpha2delta 4 )	0.879274	0	0
8	hsa781 ( calcium voltage-gated channel auxiliary subunit alpha2delta 1 )	0.872008	0	0
9	hsa774 ( calcium voltage-gated channel subunit alpha1 B )	0.849906	0	0
10	hsa55799 ( calcium voltage-gated channel auxiliary subunit alpha2delta 3 )	0.834176	0	0

D05077 : Moricizine (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D05077 ( Moricizine )

Rank	Target	Score	Validated	KEGG
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.959354	1	1
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.953147	1	1
3	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.952746	0	0
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.948798	1	1
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.935734	1	1
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.93443	1	1
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.925776	1	1
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.898714	0	0
9	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.837143	0	0
10	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.757647	0	0

D05156 : Nicotine bitartrate (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D05156 ( Nicotine bitartrate )

Rank	Target	Score	Validated	DrugBank
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.960879	1	1
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.862174	0	0
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.806747	0	0
4	hsa9312 ( potassium voltage-gated channel subfamily B member 2 )	0.802623	0	0
5	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.76532	0	0
6	hsa3782 ( potassium calcium-activated channel subfamily N member 3 )	0.747027	0	0
7	hsa3763 ( potassium voltage-gated channel subfamily J member 6 )	0.735243	0	0
8	hsa3780 ( potassium calcium-activated channel subfamily N member 1 )	0.72164	0	0
9	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.719069	0	0
10	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.689571	0	0

D05453 : Phencyclidine hydrochloride (Found 0 out of 5 validated targets)

Top-10 predicted interaction for: D05453 ( Phencyclidine hydrochloride )

Rank	Target	Score
1	hsa1141 ( cholinergic receptor nicotinic beta 2 subunit )	0.966131
2	hsa1145 ( cholinergic receptor nicotinic epsilon subunit )	0.877543
3	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.833529
4	hsa2554 ( gamma-aminobutyric acid type A receptor alpha1 subunit )	0.784018
5	hsa1144 ( cholinergic receptor nicotinic delta subunit )	0.75624
6	hsa3752 ( potassium voltage-gated channel subfamily D member 3 )	0.705178
7	hsa3738 ( potassium voltage-gated channel subfamily A member 3 )	0.69362
8	hsa1140 ( cholinergic receptor nicotinic beta 1 subunit )	0.688659
9	hsa3767 ( potassium voltage-gated channel subfamily J member 11 )	0.663062
10	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.642581

D05458 : Phentermine (Found 1 out of 1 validated targets)

Top-10 predicted interaction for: D05458 ( Phentermine )

Rank	Target	Score	Validated	DrugBank
1	hsa6532 ( solute carrier family 6 member 4 )	0.968459	1	1
2	hsa11254 ( solute carrier family 6 member 14 )	0.853287	0	0
3	hsa6331 ( sodium voltage-gated channel alpha subunit 5 )	0.837978	0	0
4	hsa6529 ( solute carrier family 6 member 1 )	0.829425	0	0
5	hsa6534 ( solute carrier family 6 member 7 )	0.828043	0	0
6	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.776309	0	0
7	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.728076	0	0
8	hsa11280 ( sodium voltage-gated channel alpha subunit 11 )	0.687278	0	0
9	hsa3758 ( potassium voltage-gated channel subfamily J member 1 )	0.682253	0	0
10	hsa3359 ( 5-hydroxytryptamine receptor 3A )	0.678775	0	0

D05461 : Enoxacin hydrate (Found 0 out of 0 validated targets)

Top-10 predicted interaction for: D05461 ( Enoxacin hydrate )

Rank	Target	Score
1	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.889263
2	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.889129
3	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.888595
4	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.846614
5	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.843287
6	hsa2569 ( gamma-aminobutyric acid type A receptor rho1 subunit )	0.841513
7	hsa2563 ( gamma-aminobutyric acid type A receptor delta subunit )	0.84054
8	hsa2562 ( gamma-aminobutyric acid type A receptor beta3 subunit )	0.839383
9	hsa2560 ( gamma-aminobutyric acid type A receptor beta1 subunit )	0.827727
10	hsa3781 ( potassium calcium-activated channel subfamily N member 2 )	0.786767

D06106 : Thiamylal (Found 10 out of 15 validated targets)

Top-10 predicted interaction for: D06106 ( Thiamylal )

Rank	Target	Score	Validated	KEGG
1	hsa2555 ( gamma-aminobutyric acid type A receptor alpha2 subunit )	0.952547	1	1
2	hsa2556 ( gamma-aminobutyric acid type A receptor alpha3 subunit )	0.948647	1	1
3	hsa2558 ( gamma-aminobutyric acid type A receptor alpha5 subunit )	0.94857	1	1
4	hsa2559 ( gamma-aminobutyric acid type A receptor alpha6 subunit )	0.946448	1	1
5	hsa2557 ( gamma-aminobutyric acid type A receptor alpha4 subunit )	0.946156	1	1
6	hsa2564 ( gamma-aminobutyric acid type A receptor epsilon subunit )	0.853138	1	1
7	hsa2566 ( gamma-aminobutyric acid type A receptor gamma2 subunit )	0.852193	1	1
8	hsa2567 ( gamma-aminobutyric acid type A receptor gamma3 subunit )	0.85171	1	1
9	hsa55879 ( gamma-aminobutyric acid type A receptor theta subunit )	0.825799	1	1
10	hsa2561 ( gamma-aminobutyric acid type A receptor beta2 subunit )	0.821269	1	1

D06172 : Tocainide (Found 6 out of 6 validated targets)

Top-10 predicted interaction for: D06172 ( Tocainide )

Rank	Target	Score	Validated	KEGG
1	hsa6323 ( sodium voltage-gated channel alpha subunit 1 )	0.976669	1	1
2	hsa6328 ( sodium voltage-gated channel alpha subunit 3 )	0.97252	1	1
3	hsa6336 ( sodium voltage-gated channel alpha subunit 10 )	0.971519	0	0
4	hsa6329 ( sodium voltage-gated channel alpha subunit 4 )	0.970004	1	1
5	hsa6326 ( sodium voltage-gated channel alpha subunit 2 )	0.961816	1	1
6	hsa6334 ( sodium voltage-gated channel alpha subunit 8 )	0.960249	1	1
7	hsa6335 ( sodium voltage-gated channel alpha subunit 9 )	0.954249	1	1
8	hsa8645 ( potassium two pore domain channel subfamily K member 5 )	0.929685	0	0
9	hsa6332 ( sodium voltage-gated channel alpha subunit 7 )	0.747751	0	0
10	hsa3741 ( potassium voltage-gated channel subfamily A member 5 )	0.747021	0	0

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